The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.

Aaron Javitt; Merav D Shmueli; Matthias P Kramer; Aleksandra A Kolodziejczyk; Ivan J Cohen; Lihi Radomir; Daoud Sheban; Iris Kamer; Kevin Litchfield; Elizabeta Bab-Dinitz; Oranit Zadok; Vanessa Neiens; Adi Ulman; Hila Wolf-Levy; Avital Eisenberg-Lerner; Assaf Kacen; Michal Alon; Ana Toste Rêgo; Elvira Stacher-Priehse; Michael Lindner; Ina Koch; Jair Bar; Charles Swanton; Yardena Samuels; Yishai Levin; Paula C A da Fonseca; Eran Elinav; Nir Friedman; Silke Meiners; Yifat Merbl

doi:10.1038/s43018-023-00557-4

The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.

Aaron Javitt, Merav D Shmueli, Matthias P Kramer, Aleksandra A Kolodziejczyk, Ivan J Cohen, Lihi Radomir, Daoud Sheban, Iris Kamer, Kevin Litchfield, Elizabeta Bab-Dinitz, Oranit Zadok, Vanessa Neiens, Adi Ulman, Hila Wolf-Levy, Avital Eisenberg-Lerner, Assaf Kacen, Michal Alon, Ana Toste Rêgo, Elvira Stacher-Priehse, Michael Lindner (Co-author)Ina Koch, Jair Bar, Charles Swanton, Yardena Samuels, Yishai Levin, Paula C A da Fonseca, Eran Elinav, Nir Friedman, Silke Meiners, Yifat Merbl

Department of Surgery

Research output: Contribution to journal › Original Article › peer-review

10 Citations (Web of Science)

Original language	English
Pages (from-to)	629-647
Journal	NATURE CANCER
Volume	4
Issue number	5
DOIs	https://doi.org/10.1038/s43018-023-00557-4
Publication status	Published - 2023

Keywords

MHC CLASS-I
20 S-PROTEASOMES
ENRICHMENT ANALYSIS
GAMMA-INTERFERON
CTLA-4 BLOCKADE
REVEALS
CANCER
PA28
EXPRESSION
TUMORS

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10.1038/s43018-023-00557-4

Cite this

Javitt, A., Shmueli, M. D., Kramer, M. P., Kolodziejczyk, A. A., Cohen, I. J., Radomir, L., Sheban, D., Kamer, I., Litchfield, K., Bab-Dinitz, E., Zadok, O., Neiens, V., Ulman, A., Wolf-Levy, H., Eisenberg-Lerner, A., Kacen, A., Alon, M., Rêgo, A. T., Stacher-Priehse, E., ... Merbl, Y. (2023). The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC. NATURE CANCER, 4(5), 629-647. https://doi.org/10.1038/s43018-023-00557-4

@article{1c9e6062d8ae42df8beef71c6fa73fbf,

title = "The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.",

keywords = "MHC CLASS-I, 20 S-PROTEASOMES, ENRICHMENT ANALYSIS, GAMMA-INTERFERON, CTLA-4 BLOCKADE, REVEALS, CANCER, PA28, EXPRESSION, TUMORS",

author = "Aaron Javitt and Shmueli, {Merav D} and Kramer, {Matthias P} and Kolodziejczyk, {Aleksandra A} and Cohen, {Ivan J} and Lihi Radomir and Daoud Sheban and Iris Kamer and Kevin Litchfield and Elizabeta Bab-Dinitz and Oranit Zadok and Vanessa Neiens and Adi Ulman and Hila Wolf-Levy and Avital Eisenberg-Lerner and Assaf Kacen and Michal Alon and R{\^e}go, {Ana Toste} and Elvira Stacher-Priehse and Michael Lindner and Ina Koch and Jair Bar and Charles Swanton and Yardena Samuels and Yishai Levin and {da Fonseca}, {Paula C A} and Eran Elinav and Nir Friedman and Silke Meiners and Yifat Merbl",

year = "2023",

doi = "10.1038/s43018-023-00557-4",

language = "English",

volume = "4",

pages = "629--647",

journal = "NATURE CANCER",

issn = "2662-1347",

number = "5",

}

Javitt, A, Shmueli, MD, Kramer, MP, Kolodziejczyk, AA, Cohen, IJ, Radomir, L, Sheban, D, Kamer, I, Litchfield, K, Bab-Dinitz, E, Zadok, O, Neiens, V, Ulman, A, Wolf-Levy, H, Eisenberg-Lerner, A, Kacen, A, Alon, M, Rêgo, AT, Stacher-Priehse, E, Lindner, M, Koch, I, Bar, J, Swanton, C, Samuels, Y, Levin, Y, da Fonseca, PCA, Elinav, E, Friedman, N, Meiners, S & Merbl, Y 2023, 'The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.', NATURE CANCER, vol. 4, no. 5, pp. 629-647. https://doi.org/10.1038/s43018-023-00557-4

TY - JOUR

T1 - The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.

AU - Javitt, Aaron

AU - Shmueli, Merav D

AU - Kramer, Matthias P

AU - Kolodziejczyk, Aleksandra A

AU - Cohen, Ivan J

AU - Radomir, Lihi

AU - Sheban, Daoud

AU - Kamer, Iris

AU - Litchfield, Kevin

AU - Bab-Dinitz, Elizabeta

AU - Zadok, Oranit

AU - Neiens, Vanessa

AU - Ulman, Adi

AU - Wolf-Levy, Hila

AU - Eisenberg-Lerner, Avital

AU - Kacen, Assaf

AU - Alon, Michal

AU - Rêgo, Ana Toste

AU - Stacher-Priehse, Elvira

AU - Lindner, Michael

AU - Koch, Ina

AU - Bar, Jair

AU - Swanton, Charles

AU - Samuels, Yardena

AU - Levin, Yishai

AU - da Fonseca, Paula C A

AU - Elinav, Eran

AU - Friedman, Nir

AU - Meiners, Silke

AU - Merbl, Yifat

PY - 2023

Y1 - 2023

KW - MHC CLASS-I

KW - 20 S-PROTEASOMES

KW - ENRICHMENT ANALYSIS

KW - GAMMA-INTERFERON

KW - CTLA-4 BLOCKADE

KW - REVEALS

KW - CANCER

KW - PA28

KW - EXPRESSION

KW - TUMORS

U2 - 10.1038/s43018-023-00557-4

DO - 10.1038/s43018-023-00557-4

M3 - Original Article

C2 - 37217651

SN - 2662-1347

VL - 4

SP - 629

EP - 647

JO - NATURE CANCER

JF - NATURE CANCER

IS - 5

ER -