The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions.

Petros Christopoulos; Klaus Kluck; Martina Kirchner; Heike Lüders; Julia Roeper; Roger-Fei Falkenstern-Ge; Marlen Szewczyk; Florian Sticht; Felix C Saalfeld; Claas Wesseler; Björn Hackanson; Sebastian Dintner; Martin Faehling; Jonas Kuon; Melanie Janning; Diego Kauffmann-Guerrero; Daniel Kazdal; Sylke Kurz; Florian Eichhorn; Farastuk Bozorgmehr; Rajiv Shah; Amanda Tufman; Martin Wermke; Sonja Loges; Wolfgang M Brueckl; Christian Schulz; Daniel Misch; Nikolaj Frost; Jens Kollmeier; Martin Reck; Frank Griesinger; Christian Grohé; Jin-Liern Hong; Huamao M Lin; Jan Budczies; Albrecht Stenzinger; Michael Thomas

doi:10.1016/j.ejca.2022.04.020

The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions.

Petros Christopoulos, Klaus Kluck, Martina Kirchner, Heike Lüders, Julia Roeper, Roger-Fei Falkenstern-Ge, Marlen Szewczyk, Florian Sticht, Felix C Saalfeld, Claas Wesseler, Björn Hackanson, Sebastian Dintner, Martin Faehling, Jonas Kuon, Melanie Janning, Diego Kauffmann-Guerrero, Daniel Kazdal, Sylke Kurz, Florian Eichhorn, Farastuk BozorgmehrRajiv Shah, Amanda Tufman, Martin Wermke, Sonja Loges, Wolfgang M Brueckl (Co-author), Christian Schulz, Daniel Misch, Nikolaj Frost, Jens Kollmeier, Martin Reck, Frank Griesinger, Christian Grohé, Jin-Liern Hong, Huamao M Lin, Jan Budczies, Albrecht Stenzinger, Michael Thomas

Department of Internal Medicine III, Division of Respiratory Medicine, Allergology and Sleep Medicine

Research output: Contribution to journal › Original Article (Journal) › peer-review

17 Citations (Web of Science)

Original language	English
Pages (from-to)	106-118
Journal	EUROPEAN JOURNAL OF CANCER
Volume	170
DOIs	https://doi.org/10.1016/j.ejca.2022.04.020
Publication status	Published - 2022

Keywords

PRETREATED PATIENTS
MOBOCERTINIB
NSCLC
SURVIVAL
DIAGNOSIS

Access to Document

10.1016/j.ejca.2022.04.020

Cite this

Christopoulos, P., Kluck, K., Kirchner, M., Lüders, H., Roeper, J., Falkenstern-Ge, R.-F., Szewczyk, M., Sticht, F., Saalfeld, F. C., Wesseler, C., Hackanson, B., Dintner, S., Faehling, M., Kuon, J., Janning, M., Kauffmann-Guerrero, D., Kazdal, D., Kurz, S., Eichhorn, F., ... Thomas, M. (2022). The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions. EUROPEAN JOURNAL OF CANCER , 170, 106-118. https://doi.org/10.1016/j.ejca.2022.04.020

Christopoulos, Petros ; Kluck, Klaus ; Kirchner, Martina et al. / The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions. In: EUROPEAN JOURNAL OF CANCER 2022 ; Vol. 170. pp. 106-118.

@article{02c386e1e58348e39f69a35177e65112,

title = "The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions.",

keywords = "PRETREATED PATIENTS, MOBOCERTINIB, NSCLC, SURVIVAL, DIAGNOSIS",

author = "Petros Christopoulos and Klaus Kluck and Martina Kirchner and Heike L{\"u}ders and Julia Roeper and Roger-Fei Falkenstern-Ge and Marlen Szewczyk and Florian Sticht and Saalfeld, {Felix C} and Claas Wesseler and Bj{\"o}rn Hackanson and Sebastian Dintner and Martin Faehling and Jonas Kuon and Melanie Janning and Diego Kauffmann-Guerrero and Daniel Kazdal and Sylke Kurz and Florian Eichhorn and Farastuk Bozorgmehr and Rajiv Shah and Amanda Tufman and Martin Wermke and Sonja Loges and Brueckl, {Wolfgang M} and Christian Schulz and Daniel Misch and Nikolaj Frost and Jens Kollmeier and Martin Reck and Frank Griesinger and Christian Groh{\'e} and Jin-Liern Hong and Lin, {Huamao M} and Jan Budczies and Albrecht Stenzinger and Michael Thomas",

note = "Br{\"u}ckl: Paracelsus Medical University Nuernberg and Department of Respiratory Medicine, Allergology and Sleep Medicine/Nuernberg Lung Cancer Center, Nuernberg General Hospital, 90419, Nuernberg, Germany",

year = "2022",

doi = "10.1016/j.ejca.2022.04.020",

language = "English",

volume = "170",

pages = "106--118",

journal = "EUROPEAN JOURNAL OF CANCER ",

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}

Christopoulos, P, Kluck, K, Kirchner, M, Lüders, H, Roeper, J, Falkenstern-Ge, R-F, Szewczyk, M, Sticht, F, Saalfeld, FC, Wesseler, C, Hackanson, B, Dintner, S, Faehling, M, Kuon, J, Janning, M, Kauffmann-Guerrero, D, Kazdal, D, Kurz, S, Eichhorn, F, Bozorgmehr, F, Shah, R, Tufman, A, Wermke, M, Loges, S, Brueckl, WM, Schulz, C, Misch, D, Frost, N, Kollmeier, J, Reck, M, Griesinger, F, Grohé, C, Hong, J-L, Lin, HM, Budczies, J, Stenzinger, A & Thomas, M 2022, 'The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions.', EUROPEAN JOURNAL OF CANCER , vol. 170, pp. 106-118. https://doi.org/10.1016/j.ejca.2022.04.020

The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions. / Christopoulos, Petros; Kluck, Klaus; Kirchner, Martina et al.
In: EUROPEAN JOURNAL OF CANCER , Vol. 170, 2022, p. 106-118.

Research output: Contribution to journal › Original Article (Journal) › peer-review

TY - JOUR

T1 - The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions.

AU - Christopoulos, Petros

AU - Kluck, Klaus

AU - Kirchner, Martina

AU - Lüders, Heike

AU - Roeper, Julia

AU - Falkenstern-Ge, Roger-Fei

AU - Szewczyk, Marlen

AU - Sticht, Florian

AU - Saalfeld, Felix C

AU - Wesseler, Claas

AU - Hackanson, Björn

AU - Dintner, Sebastian

AU - Faehling, Martin

AU - Kuon, Jonas

AU - Janning, Melanie

AU - Kauffmann-Guerrero, Diego

AU - Kazdal, Daniel

AU - Kurz, Sylke

AU - Eichhorn, Florian

AU - Bozorgmehr, Farastuk

AU - Shah, Rajiv

AU - Tufman, Amanda

AU - Wermke, Martin

AU - Loges, Sonja

AU - Brueckl, Wolfgang M

AU - Schulz, Christian

AU - Misch, Daniel

AU - Frost, Nikolaj

AU - Kollmeier, Jens

AU - Reck, Martin

AU - Griesinger, Frank

AU - Grohé, Christian

AU - Hong, Jin-Liern

AU - Lin, Huamao M

AU - Budczies, Jan

AU - Stenzinger, Albrecht

AU - Thomas, Michael

N1 - Brückl: Paracelsus Medical University Nuernberg and Department of Respiratory Medicine, Allergology and Sleep Medicine/Nuernberg Lung Cancer Center, Nuernberg General Hospital, 90419, Nuernberg, Germany

PY - 2022

Y1 - 2022

KW - PRETREATED PATIENTS

KW - MOBOCERTINIB

KW - NSCLC

KW - SURVIVAL

KW - DIAGNOSIS

U2 - 10.1016/j.ejca.2022.04.020

DO - 10.1016/j.ejca.2022.04.020

M3 - Original Article (Journal)

C2 - 35598358

SN - 0959-8049

VL - 170

SP - 106

EP - 118

JO - EUROPEAN JOURNAL OF CANCER

JF - EUROPEAN JOURNAL OF CANCER

ER -

Christopoulos P, Kluck K, Kirchner M, Lüders H, Roeper J, Falkenstern-Ge RF et al. The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions. EUROPEAN JOURNAL OF CANCER . 2022;170:106-118. doi: 10.1016/j.ejca.2022.04.020