The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

Anja M Schaible; Rosanna Filosa; Verena Krauth; Veronika Temml; Simona Pace; Ulrike Garscha; Stefanie Liening; Christina Weinigel; Silke Rummler; Sebastian Schieferdecker; Markus Nett; Antonella Peduto; Selene Collarile; Maria Scuotto; Fioretina Roviezzo; Giuseppe Spaziano; Mario de Rosa; Hermann Stuppner; Daniela Brigitte Schuster; Bruno D"Agostino; Oliver Werz

doi:10.1016/j.bcp.2016.04.019

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

Anja M Schaible, Rosanna Filosa, Verena Krauth, Veronika Temml, Simona Pace, Ulrike Garscha, Stefanie Liening, Christina Weinigel, Silke Rummler, Sebastian Schieferdecker, Markus Nett, Antonella Peduto, Selene Collarile, Maria Scuotto, Fioretina Roviezzo, Giuseppe Spaziano, Mario de Rosa, Hermann Stuppner, Daniela Brigitte Schuster, Bruno D"AgostinoOliver Werz

Insitute of Pharmacy

Research output: Contribution to journal › Original Article (Journal) › peer-review

24 Citations (Web of Science)

Original language	English
Pages (from-to)	60-71
Journal	BIOCHEMICAL PHARMACOLOGY
Volume	112
DOIs	https://doi.org/10.1016/j.bcp.2016.04.019
Publication status	Published - 2016

Keywords

ARACHIDONIC-ACID RELEASE
MOUSE LUNG
ZILEUTON
ACTIVATION
DISEASE
BLOOD
1,4-BENZOQUINONE
LEUKOCYTES
HYPERFORIN
CYTOKINES

Access to Document

10.1016/j.bcp.2016.04.019

Cite this

Schaible, A. M., Filosa, R., Krauth, V., Temml, V., Pace, S., Garscha, U., Liening, S., Weinigel, C., Rummler, S., Schieferdecker, S., Nett, M., Peduto, A., Collarile, S., Scuotto, M., Roviezzo, F., Spaziano, G., de Rosa, M., Stuppner, H., Schuster, D. B., ... Werz, O. (2016). The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. BIOCHEMICAL PHARMACOLOGY , 112, 60-71. https://doi.org/10.1016/j.bcp.2016.04.019

Schaible, Anja M ; Filosa, Rosanna ; Krauth, Verena et al. / The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. In: BIOCHEMICAL PHARMACOLOGY 2016 ; Vol. 112. pp. 60-71.

@article{880299264d92452d834aa6eb74e9fd93,

title = "The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.",

keywords = "ARACHIDONIC-ACID RELEASE, MOUSE LUNG, ZILEUTON, ACTIVATION, DISEASE, BLOOD, 1,4-BENZOQUINONE, LEUKOCYTES, HYPERFORIN, CYTOKINES",

author = "Schaible, {Anja M} and Rosanna Filosa and Verena Krauth and Veronika Temml and Simona Pace and Ulrike Garscha and Stefanie Liening and Christina Weinigel and Silke Rummler and Sebastian Schieferdecker and Markus Nett and Antonella Peduto and Selene Collarile and Maria Scuotto and Fioretina Roviezzo and Giuseppe Spaziano and {de Rosa}, Mario and Hermann Stuppner and Schuster, {Daniela Brigitte} and Bruno D{"}Agostino and Oliver Werz",

year = "2016",

doi = "10.1016/j.bcp.2016.04.019",

language = "English",

volume = "112",

pages = "60--71",

journal = "BIOCHEMICAL PHARMACOLOGY ",

issn = "0006-2952",

publisher = "Elsevier ",

}

Schaible, AM, Filosa, R, Krauth, V, Temml, V, Pace, S, Garscha, U, Liening, S, Weinigel, C, Rummler, S, Schieferdecker, S, Nett, M, Peduto, A, Collarile, S, Scuotto, M, Roviezzo, F, Spaziano, G, de Rosa, M, Stuppner, H, Schuster, DB, D"Agostino, B & Werz, O 2016, 'The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.', BIOCHEMICAL PHARMACOLOGY , vol. 112, pp. 60-71. https://doi.org/10.1016/j.bcp.2016.04.019

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. / Schaible, Anja M; Filosa, Rosanna; Krauth, Verena et al.
In: BIOCHEMICAL PHARMACOLOGY , Vol. 112, 2016, p. 60-71.

Research output: Contribution to journal › Original Article (Journal) › peer-review

TY - JOUR

T1 - The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

AU - Schaible, Anja M

AU - Filosa, Rosanna

AU - Krauth, Verena

AU - Temml, Veronika

AU - Pace, Simona

AU - Garscha, Ulrike

AU - Liening, Stefanie

AU - Weinigel, Christina

AU - Rummler, Silke

AU - Schieferdecker, Sebastian

AU - Nett, Markus

AU - Peduto, Antonella

AU - Collarile, Selene

AU - Scuotto, Maria

AU - Roviezzo, Fioretina

AU - Spaziano, Giuseppe

AU - de Rosa, Mario

AU - Stuppner, Hermann

AU - Schuster, Daniela Brigitte

AU - D"Agostino, Bruno

AU - Werz, Oliver

PY - 2016

Y1 - 2016

KW - ARACHIDONIC-ACID RELEASE

KW - MOUSE LUNG

KW - ZILEUTON

KW - ACTIVATION

KW - DISEASE

KW - BLOOD

KW - 1,4-BENZOQUINONE

KW - LEUKOCYTES

KW - HYPERFORIN

KW - CYTOKINES

U2 - 10.1016/j.bcp.2016.04.019

DO - 10.1016/j.bcp.2016.04.019

M3 - Original Article (Journal)

C2 - 27157409

SN - 0006-2952

VL - 112

SP - 60

EP - 71

JO - BIOCHEMICAL PHARMACOLOGY

JF - BIOCHEMICAL PHARMACOLOGY

ER -

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U et al. The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. BIOCHEMICAL PHARMACOLOGY . 2016;112:60-71. doi: 10.1016/j.bcp.2016.04.019