Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

Julia Marschallinger; Iris Schäffner; Barbara Klein; Renate Gelfert; Francisco J Rivera; Sebastian Illes; Lukas Grassner; Maximilian Janssen; Peter Rotheneichner; Claudia Schmuckermair; Roland Coras; Marta Boccazzi; Mansoor Chishty; Florian Lagler; Marija Renic; Hans Christian Bauer; Nicolas Singewald; Ingmar Blümcke; Ulrich Bogdahn; Sebastien Couillard-Despres; D Chichung Lie; Maria P Abbracchio; Ludwig Aigner

doi:10.1038/ncomms9466

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

Julia Marschallinger (First author)
, Iris Schäffner
, Barbara Klein (Co-author)
, Renate Gelfert
, Francisco J Rivera
, Sebastian Illes (Co-author)
, Lukas Grassner (Co-author)
, Maximilian Janssen
, Peter Rotheneichner (Co-author)
, Claudia Schmuckermair
, Roland Coras
, Marta Boccazzi
, Mansoor Chishty
, Florian Lagler (Co-author)
, Marija Renic
, Hans Christian Bauer (Co-author)
, Nicolas Singewald
, Ingmar Blümcke
, Ulrich Bogdahn
, Sebastien Couillard-Despres (Co-author)

D Chichung Lie, Maria P Abbracchio, Ludwig Aigner^* (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article › peer-review

161 Citations (Web of Science)

Original language	English
Pages (from-to)	8466
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms9466
Publication status	Published - 2015

Keywords

LEUKOTRIENE RECEPTOR-1 ANTAGONIST
SPINAL-CORD-INJURY
HIPPOCAMPAL NEUROGENESIS
ALZHEIMERS-DISEASE
AUTOIMMUNE ENCEPHALOMYELITIS
PROGENITOR PROLIFERATION
MICROGLIAL ACTIVATION
COGNITIVE FUNCTION
CEREBRAL-ISCHEMIA
CELL HOMEOSTASIS

Access to Document

10.1038/ncomms9466

Leukotrienes in human cerebrospinal fluid: a potential novel biomarker for Alzheimer's disease development and progression?
Marschallinger, J. (PI)
1/04/15 → 1/04/16
Project: Research
Brain Rejuvenation Through Inhibition of Leukotriene Signaling: Molecular and Cellular Mechanisms
Marschallinger, J. (PI)
15/03/15 → 15/03/17
Project: Research
Mesenchymal Stem Cells Therapy: The Fountain of Youth For Remyelination
Rivera Gomez-Barris, F. J. (PI)
15/12/13 → 15/08/15
Project: Research

Cite this

Marschallinger, J., Schäffner, I., Klein, B., Gelfert, R., Rivera, F. J., Illes, S., Grassner, L., Janssen, M., Rotheneichner, P., Schmuckermair, C., Coras, R., Boccazzi, M., Chishty, M., Lagler, F., Renic, M., Bauer, H. C., Singewald, N., Blümcke, I., Bogdahn, U., ... Aigner, L. (2015). Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nature Communications, 6, 8466. https://doi.org/10.1038/ncomms9466

@article{250875daaa5e4783a558060684ef00da,

title = "Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.",

keywords = "LEUKOTRIENE RECEPTOR-1 ANTAGONIST, SPINAL-CORD-INJURY, HIPPOCAMPAL NEUROGENESIS, ALZHEIMERS-DISEASE, AUTOIMMUNE ENCEPHALOMYELITIS, PROGENITOR PROLIFERATION, MICROGLIAL ACTIVATION, COGNITIVE FUNCTION, CEREBRAL-ISCHEMIA, CELL HOMEOSTASIS",

author = "Julia Marschallinger and Iris Sch{\"a}ffner and Barbara Klein and Renate Gelfert and Rivera, \{Francisco J\} and Sebastian Illes and Lukas Grassner and Maximilian Janssen and Peter Rotheneichner and Claudia Schmuckermair and Roland Coras and Marta Boccazzi and Mansoor Chishty and Florian Lagler and Marija Renic and Bauer, \{Hans Christian\} and Nicolas Singewald and Ingmar Bl{\"u}mcke and Ulrich Bogdahn and Sebastien Couillard-Despres and Lie, \{D Chichung\} and Abbracchio, \{Maria P\} and Ludwig Aigner",

note = "Marschallinger, Klein, Gelfert, Rivera, Illes, Grassner, Janssen, Rotheneichner, Aigner: Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria; Marschallinger, Klein, Gelfert, Rivera, Illes, Grassner, Janssen, Rotheneichner, Bauer, Couillard-Despres, Aigner: Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, 5020 Salzburg, Austria; Grassner: Center for Spinal Cord Injuries, BG Trauma Center Murnau, 82418 Murnau am Staffelsee, Germany; Rotheneichner, Couillard-Despres: Institute of Experimental Neuroregeneration, Paracelsus Medical University, 5020 Salzburg, Austria; Lagler: Department for Paediatrics, Institute for Inborn Errors of Metabolism, Paracelsus Medical University, 5020 Salzburg, Austria; Bauer: Institute of Tendon and Bone Regeneration, Paracelsus Medical University, 5020 Salzburg, Austria",

year = "2015",

doi = "10.1038/ncomms9466",

language = "English",

volume = "6",

pages = "8466",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "NATURE PORTFOLIO",

}

Marschallinger, J, Schäffner, I, Klein, B, Gelfert, R, Rivera, FJ, Illes, S, Grassner, L, Janssen, M, Rotheneichner, P, Schmuckermair, C, Coras, R, Boccazzi, M, Chishty, M, Lagler, F, Renic, M, Bauer, HC, Singewald, N, Blümcke, I, Bogdahn, U, Couillard-Despres, S, Lie, DC, Abbracchio, MP & Aigner, L 2015, 'Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.', Nature Communications, vol. 6, pp. 8466. https://doi.org/10.1038/ncomms9466

TY - JOUR

T1 - Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

AU - Marschallinger, Julia

AU - Schäffner, Iris

AU - Klein, Barbara

AU - Gelfert, Renate

AU - Rivera, Francisco J

AU - Illes, Sebastian

AU - Grassner, Lukas

AU - Janssen, Maximilian

AU - Rotheneichner, Peter

AU - Schmuckermair, Claudia

AU - Coras, Roland

AU - Boccazzi, Marta

AU - Chishty, Mansoor

AU - Lagler, Florian

AU - Renic, Marija

AU - Bauer, Hans Christian

AU - Singewald, Nicolas

AU - Blümcke, Ingmar

AU - Bogdahn, Ulrich

AU - Couillard-Despres, Sebastien

AU - Lie, D Chichung

AU - Abbracchio, Maria P

AU - Aigner, Ludwig

N1 - Marschallinger, Klein, Gelfert, Rivera, Illes, Grassner, Janssen, Rotheneichner, Aigner: Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria; Marschallinger, Klein, Gelfert, Rivera, Illes, Grassner, Janssen, Rotheneichner, Bauer, Couillard-Despres, Aigner: Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, 5020 Salzburg, Austria; Grassner: Center for Spinal Cord Injuries, BG Trauma Center Murnau, 82418 Murnau am Staffelsee, Germany; Rotheneichner, Couillard-Despres: Institute of Experimental Neuroregeneration, Paracelsus Medical University, 5020 Salzburg, Austria; Lagler: Department for Paediatrics, Institute for Inborn Errors of Metabolism, Paracelsus Medical University, 5020 Salzburg, Austria; Bauer: Institute of Tendon and Bone Regeneration, Paracelsus Medical University, 5020 Salzburg, Austria

PY - 2015

Y1 - 2015

KW - LEUKOTRIENE RECEPTOR-1 ANTAGONIST

KW - SPINAL-CORD-INJURY

KW - HIPPOCAMPAL NEUROGENESIS

KW - ALZHEIMERS-DISEASE

KW - AUTOIMMUNE ENCEPHALOMYELITIS

KW - PROGENITOR PROLIFERATION

KW - MICROGLIAL ACTIVATION

KW - COGNITIVE FUNCTION

KW - CEREBRAL-ISCHEMIA

KW - CELL HOMEOSTASIS

U2 - 10.1038/ncomms9466

DO - 10.1038/ncomms9466

M3 - Original Article

C2 - 26506265

SN - 2041-1723

VL - 6

SP - 8466

JO - Nature Communications

JF - Nature Communications

ER -

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

Keywords

Access to Document

Projects

Leukotrienes in human cerebrospinal fluid: a potential novel biomarker for Alzheimer's disease development and progression?

Brain Rejuvenation Through Inhibition of Leukotriene Signaling: Molecular and Cellular Mechanisms

Mesenchymal Stem Cells Therapy: The Fountain of Youth For Remyelination

Cite this