Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.

Eugene Park; Jingyu Chen; Andrew Moore; Maurizio Mangolini; Antonella Santoro; Joseph R Boyd; Hilde Schjerven; Veronika Ecker; Maike Buchner; James C Williamson; Paul J Lehner; Luca Gasparoli; Owen Williams; Johannes Bloehdorn; Stephan Stilgenbauer; Michael Leitges; Alexander Egle; Marc Schmidt-Supprian; Seth Frietze; Ingo Ringshausen

doi:10.1126/scitranslmed.aax9340

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.

Eugene Park
, Jingyu Chen
, Andrew Moore
, Maurizio Mangolini
, Antonella Santoro
, Joseph R Boyd
, Hilde Schjerven
, Veronika Ecker
, Maike Buchner
, James C Williamson
, Paul J Lehner
, Luca Gasparoli
, Owen Williams
, Johannes Bloehdorn
, Stephan Stilgenbauer
, Michael Leitges
, Alexander Egle (Co-author)
, Marc Schmidt-Supprian
, Seth Frietze
, Ingo Ringshausen

Department of Internal Medicine III - Division of Hematology, Medical Oncology, Hemostaseology, Rheumatology, Infectiology and Oncologic Center

Research output: Contribution to journal › Original Article › peer-review

26 Citations (Web of Science)

Original language	English
Journal	SCIENCE TRANSLATIONAL MEDICINE
Volume	12
Issue number	526
DOIs	https://doi.org/10.1126/scitranslmed.aax9340
Publication status	Published - 2020

Keywords

CHRONIC LYMPHOCYTIC-LEUKEMIA
I-KAPPA-B
ACUTE LYMPHOBLASTIC-LEUKEMIA
ACUTE MYELOID-LEUKEMIA
PKC-BETA
CHEMOTHERAPY
ACTIVATION
EXPRESSION
DISTINCT
PROGRESSION

Access to Document

10.1126/scitranslmed.aax9340

Cite this

Park, E., Chen, J., Moore, A., Mangolini, M., Santoro, A., Boyd, J. R., Schjerven, H., Ecker, V., Buchner, M., Williamson, J. C., Lehner, P. J., Gasparoli, L., Williams, O., Bloehdorn, J., Stilgenbauer, S., Leitges, M., Egle, A., Schmidt-Supprian, M., Frietze, S., & Ringshausen, I. (2020). Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance. SCIENCE TRANSLATIONAL MEDICINE, 12(526). https://doi.org/10.1126/scitranslmed.aax9340

@article{68c03e0caefe403e90c0569c399b148b,

title = "Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.",

keywords = "CHRONIC LYMPHOCYTIC-LEUKEMIA, I-KAPPA-B, ACUTE LYMPHOBLASTIC-LEUKEMIA, ACUTE MYELOID-LEUKEMIA, PKC-BETA, CHEMOTHERAPY, ACTIVATION, EXPRESSION, DISTINCT, PROGRESSION",

author = "Eugene Park and Jingyu Chen and Andrew Moore and Maurizio Mangolini and Antonella Santoro and Boyd, \{Joseph R\} and Hilde Schjerven and Veronika Ecker and Maike Buchner and Williamson, \{James C\} and Lehner, \{Paul J\} and Luca Gasparoli and Owen Williams and Johannes Bloehdorn and Stephan Stilgenbauer and Michael Leitges and Alexander Egle and Marc Schmidt-Supprian and Seth Frietze and Ingo Ringshausen",

note = "Egler: IIIrd Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University, Cancer Cluster Salzburg, 5020 Salzburg, Austria.",

year = "2020",

doi = "10.1126/scitranslmed.aax9340",

language = "English",

volume = "12",

journal = "SCIENCE TRANSLATIONAL MEDICINE",

issn = "1946-6234",

number = "526",

}

Park, E, Chen, J, Moore, A, Mangolini, M, Santoro, A, Boyd, JR, Schjerven, H, Ecker, V, Buchner, M, Williamson, JC, Lehner, PJ, Gasparoli, L, Williams, O, Bloehdorn, J, Stilgenbauer, S, Leitges, M, Egle, A, Schmidt-Supprian, M, Frietze, S & Ringshausen, I 2020, 'Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.', SCIENCE TRANSLATIONAL MEDICINE, vol. 12, no. 526. https://doi.org/10.1126/scitranslmed.aax9340

TY - JOUR

T1 - Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.

AU - Park, Eugene

AU - Chen, Jingyu

AU - Moore, Andrew

AU - Mangolini, Maurizio

AU - Santoro, Antonella

AU - Boyd, Joseph R

AU - Schjerven, Hilde

AU - Ecker, Veronika

AU - Buchner, Maike

AU - Williamson, James C

AU - Lehner, Paul J

AU - Gasparoli, Luca

AU - Williams, Owen

AU - Bloehdorn, Johannes

AU - Stilgenbauer, Stephan

AU - Leitges, Michael

AU - Egle, Alexander

AU - Schmidt-Supprian, Marc

AU - Frietze, Seth

AU - Ringshausen, Ingo

N1 - Egler: IIIrd Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University, Cancer Cluster Salzburg, 5020 Salzburg, Austria.

PY - 2020

Y1 - 2020

KW - CHRONIC LYMPHOCYTIC-LEUKEMIA

KW - I-KAPPA-B

KW - ACUTE LYMPHOBLASTIC-LEUKEMIA

KW - ACUTE MYELOID-LEUKEMIA

KW - PKC-BETA

KW - CHEMOTHERAPY

KW - ACTIVATION

KW - EXPRESSION

KW - DISTINCT

KW - PROGRESSION

U2 - 10.1126/scitranslmed.aax9340

DO - 10.1126/scitranslmed.aax9340

M3 - Original Article

C2 - 31941829

SN - 1946-6234

VL - 12

JO - SCIENCE TRANSLATIONAL MEDICINE

JF - SCIENCE TRANSLATIONAL MEDICINE

IS - 526

ER -