Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

Sima Khazaei; Carol C L Chen; Augusto Faria Andrade; Nisha Kabir; Pariya Azarafshar; Shahir M Morcos; Josiane Alves França; Mariana Lopes; Peder J Lund; Geoffroy Danieau; Samantha Worme; Lata Adnani; Nadine Nzirorera; Xiao Chen; Gayathri Yogarajah; Caterina Russo; Michele Zeinieh; Cassandra J Wong; Laura Bryant; Steven Hébert; Bethany Tong; Tianna S Sihota; Damien Faury; Evan Puligandla; Wajih Jawhar; Veronica Sandy; Mitra Cowan; Emily M Nakada; Loydie A Jerome-Majewska; Benjamin Ellezam; Carolina Cavalieri Gomes; Jonas Denecke; Davor Lessel; Marie T McDonald; Carolyn E Pizoli; Kathryn Taylor; Benjamin T Cocanougher; Elizabeth J Bhoj; Anne-Claude Gingras; Benjamin A Garcia; Chao Lu; Eric I Campos; Claudia L Kleinman; Livia Garzia; Nada Jabado

doi:10.1016/j.cell.2023.02.023

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

Sima Khazaei
, Carol C L Chen
, Augusto Faria Andrade
, Nisha Kabir
, Pariya Azarafshar
, Shahir M Morcos
, Josiane Alves França
, Mariana Lopes
, Peder J Lund
, Geoffroy Danieau
, Samantha Worme
, Lata Adnani
, Nadine Nzirorera
, Xiao Chen
, Gayathri Yogarajah
, Caterina Russo
, Michele Zeinieh
, Cassandra J Wong
, Laura Bryant
, Steven Hébert

Bethany Tong, Tianna S Sihota, Damien Faury, Evan Puligandla, Wajih Jawhar, Veronica Sandy, Mitra Cowan, Emily M Nakada, Loydie A Jerome-Majewska, Benjamin Ellezam, Carolina Cavalieri Gomes, Jonas Denecke, Davor Lessel (Co-author), Marie T McDonald, Carolyn E Pizoli, Kathryn Taylor, Benjamin T Cocanougher, Elizabeth J Bhoj, Anne-Claude Gingras, Benjamin A Garcia, Chao Lu, Eric I Campos, Claudia L Kleinman, Livia Garzia, Nada Jabado

Institute of Human Genetics

Research output: Contribution to journal › Original Article › peer-review

44 Citations (Web of Science)

Original language	English
Pages (from-to)	1162-1178.e20
Journal	CELL
Volume	186
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2023.02.023
Publication status	Published - 16 Mar 2023

Keywords

Animals
DNA (Cytosine-5-)-Methyltransferases/genetics
DNA Methylation/genetics
DNA Methyltransferase 3A
DNA Modification Methylases/genetics
Histones/metabolism
Mice
Neuroinflammatory Diseases

Access to Document

10.1016/j.cell.2023.02.023

Cite this

Khazaei, S., Chen, C. C. L., Andrade, A. F., Kabir, N., Azarafshar, P., Morcos, S. M., França, J. A., Lopes, M., Lund, P. J., Danieau, G., Worme, S., Adnani, L., Nzirorera, N., Chen, X., Yogarajah, G., Russo, C., Zeinieh, M., Wong, C. J., Bryant, L., ... Jabado, N. (2023). Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration. CELL, 186(6), 1162-1178.e20. https://doi.org/10.1016/j.cell.2023.02.023

@article{c2769ff9b80f4ceb815caf792a9b37de,

title = "Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration",

keywords = "Animals, DNA (Cytosine-5-)-Methyltransferases/genetics, DNA Methylation/genetics, DNA Methyltransferase 3A, DNA Modification Methylases/genetics, Histones/metabolism, Mice, Neuroinflammatory Diseases",

author = "Sima Khazaei and Chen, \{Carol C L\} and Andrade, \{Augusto Faria\} and Nisha Kabir and Pariya Azarafshar and Morcos, \{Shahir M\} and Fran{\c c}a, \{Josiane Alves\} and Mariana Lopes and Lund, \{Peder J\} and Geoffroy Danieau and Samantha Worme and Lata Adnani and Nadine Nzirorera and Xiao Chen and Gayathri Yogarajah and Caterina Russo and Michele Zeinieh and Wong, \{Cassandra J\} and Laura Bryant and Steven H{\'e}bert and Bethany Tong and Sihota, \{Tianna S\} and Damien Faury and Evan Puligandla and Wajih Jawhar and Veronica Sandy and Mitra Cowan and Nakada, \{Emily M\} and Jerome-Majewska, \{Loydie A\} and Benjamin Ellezam and Gomes, \{Carolina Cavalieri\} and Jonas Denecke and Davor Lessel and McDonald, \{Marie T\} and Pizoli, \{Carolyn E\} and Kathryn Taylor and Cocanougher, \{Benjamin T\} and Bhoj, \{Elizabeth J\} and Anne-Claude Gingras and Garcia, \{Benjamin A\} and Chao Lu and Campos, \{Eric I\} and Kleinman, \{Claudia L\} and Livia Garzia and Nada Jabado",

note = "Lessel: Institute of Human Genetics, University Hospital of the Paracelsus Medical University Salzburg, Salzburg, Austria",

year = "2023",

month = mar,

day = "16",

doi = "10.1016/j.cell.2023.02.023",

language = "English",

volume = "186",

pages = "1162--1178.e20",

journal = "CELL",

issn = "0092-8674",

publisher = "Cell Press ",

number = "6",

}

Khazaei, S, Chen, CCL, Andrade, AF, Kabir, N, Azarafshar, P, Morcos, SM, França, JA, Lopes, M, Lund, PJ, Danieau, G, Worme, S, Adnani, L, Nzirorera, N, Chen, X, Yogarajah, G, Russo, C, Zeinieh, M, Wong, CJ, Bryant, L, Hébert, S, Tong, B, Sihota, TS, Faury, D, Puligandla, E, Jawhar, W, Sandy, V, Cowan, M, Nakada, EM, Jerome-Majewska, LA, Ellezam, B, Gomes, CC, Denecke, J, Lessel, D, McDonald, MT, Pizoli, CE, Taylor, K, Cocanougher, BT, Bhoj, EJ, Gingras, A-C, Garcia, BA, Lu, C, Campos, EI, Kleinman, CL, Garzia, L & Jabado, N 2023, 'Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration', CELL, vol. 186, no. 6, pp. 1162-1178.e20. https://doi.org/10.1016/j.cell.2023.02.023

TY - JOUR

T1 - Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

AU - Khazaei, Sima

AU - Chen, Carol C L

AU - Andrade, Augusto Faria

AU - Kabir, Nisha

AU - Azarafshar, Pariya

AU - Morcos, Shahir M

AU - França, Josiane Alves

AU - Lopes, Mariana

AU - Lund, Peder J

AU - Danieau, Geoffroy

AU - Worme, Samantha

AU - Adnani, Lata

AU - Nzirorera, Nadine

AU - Chen, Xiao

AU - Yogarajah, Gayathri

AU - Russo, Caterina

AU - Zeinieh, Michele

AU - Wong, Cassandra J

AU - Bryant, Laura

AU - Hébert, Steven

AU - Tong, Bethany

AU - Sihota, Tianna S

AU - Faury, Damien

AU - Puligandla, Evan

AU - Jawhar, Wajih

AU - Sandy, Veronica

AU - Cowan, Mitra

AU - Nakada, Emily M

AU - Jerome-Majewska, Loydie A

AU - Ellezam, Benjamin

AU - Gomes, Carolina Cavalieri

AU - Denecke, Jonas

AU - Lessel, Davor

AU - McDonald, Marie T

AU - Pizoli, Carolyn E

AU - Taylor, Kathryn

AU - Cocanougher, Benjamin T

AU - Bhoj, Elizabeth J

AU - Gingras, Anne-Claude

AU - Garcia, Benjamin A

AU - Lu, Chao

AU - Campos, Eric I

AU - Kleinman, Claudia L

AU - Garzia, Livia

AU - Jabado, Nada

N1 - Lessel: Institute of Human Genetics, University Hospital of the Paracelsus Medical University Salzburg, Salzburg, Austria

PY - 2023/3/16

Y1 - 2023/3/16

KW - Animals

KW - DNA (Cytosine-5-)-Methyltransferases/genetics

KW - DNA Methylation/genetics

KW - DNA Methyltransferase 3A

KW - DNA Modification Methylases/genetics

KW - Histones/metabolism

KW - Mice

KW - Neuroinflammatory Diseases

U2 - 10.1016/j.cell.2023.02.023

DO - 10.1016/j.cell.2023.02.023

M3 - Original Article

C2 - 36931244

SN - 0092-8674

VL - 186

SP - 1162-1178.e20

JO - CELL

JF - CELL

IS - 6

ER -