Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis

Mareike Lehmann; Martina Korfei; Kathrin Mutze; Stephan Klee; Wioletta Skronska-Wasek; Hani N Alsafadi; Chiharu Ota; Rita Costa; Herbert B Schiller; Michael Lindner; Darcy E Wagner; Andreas Günther; Melanie Königshoff

doi:10.1183/13993003.02367-2016

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis

Mareike Lehmann, Martina Korfei, Kathrin Mutze, Stephan Klee, Wioletta Skronska-Wasek, Hani N Alsafadi, Chiharu Ota, Rita Costa, Herbert B Schiller, Michael Lindner, Darcy E Wagner, Andreas Günther, Melanie Königshoff

Department of Surgery

Research output: Contribution to journal › Original Article › peer-review

248 Citations (Web of Science)

Original language	English
Journal	EUROPEAN RESPIRATORY JOURNAL
Volume	50
Issue number	2
DOIs	https://doi.org/10.1183/13993003.02367-2016
Publication status	Published - 2017

Keywords

IDIOPATHIC PULMONARY-FIBROSIS
SENESCENT CELLS
SECRETORY PHENOTYPE
STRAND BREAKS
MOUSE MODEL
MICE
EXPRESSION
HALLMARKS
INJURY
PATHOGENESIS

Access to Document

10.1183/13993003.02367-2016

Cite this

Lehmann, M., Korfei, M., Mutze, K., Klee, S., Skronska-Wasek, W., Alsafadi, H. N., Ota, C., Costa, R., Schiller, H. B., Lindner, M., Wagner, D. E., Günther, A., & Königshoff, M. (2017). Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis . EUROPEAN RESPIRATORY JOURNAL , 50(2). https://doi.org/10.1183/13993003.02367-2016

Lehmann, Mareike ; Korfei, Martina ; Mutze, Kathrin et al. / Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis . In: EUROPEAN RESPIRATORY JOURNAL 2017 ; Vol. 50, No. 2.

@article{3ffc60f5661b43eaba532109e498b818,

title = "Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ",

keywords = "IDIOPATHIC PULMONARY-FIBROSIS, SENESCENT CELLS, SECRETORY PHENOTYPE, STRAND BREAKS, MOUSE MODEL, MICE, EXPRESSION, HALLMARKS, INJURY, PATHOGENESIS",

author = "Mareike Lehmann and Martina Korfei and Kathrin Mutze and Stephan Klee and Wioletta Skronska-Wasek and Alsafadi, {Hani N} and Chiharu Ota and Rita Costa and Schiller, {Herbert B} and Michael Lindner and Wagner, {Darcy E} and Andreas G{\"u}nther and Melanie K{\"o}nigshoff",

year = "2017",

doi = "10.1183/13993003.02367-2016",

language = "English",

volume = "50",

journal = "EUROPEAN RESPIRATORY JOURNAL ",

issn = "0903-1936",

number = "2",

}

Lehmann, M, Korfei, M, Mutze, K, Klee, S, Skronska-Wasek, W, Alsafadi, HN, Ota, C, Costa, R, Schiller, HB, Lindner, M, Wagner, DE, Günther, A & Königshoff, M 2017, 'Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ', EUROPEAN RESPIRATORY JOURNAL , vol. 50, no. 2. https://doi.org/10.1183/13993003.02367-2016

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis . / Lehmann, Mareike; Korfei, Martina; Mutze, Kathrin et al.
In: EUROPEAN RESPIRATORY JOURNAL , Vol. 50, No. 2, 2017.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis

AU - Lehmann, Mareike

AU - Korfei, Martina

AU - Mutze, Kathrin

AU - Klee, Stephan

AU - Skronska-Wasek, Wioletta

AU - Alsafadi, Hani N

AU - Ota, Chiharu

AU - Costa, Rita

AU - Schiller, Herbert B

AU - Lindner, Michael

AU - Wagner, Darcy E

AU - Günther, Andreas

AU - Königshoff, Melanie

PY - 2017

Y1 - 2017

KW - IDIOPATHIC PULMONARY-FIBROSIS

KW - SENESCENT CELLS

KW - SECRETORY PHENOTYPE

KW - STRAND BREAKS

KW - MOUSE MODEL

KW - MICE

KW - EXPRESSION

KW - HALLMARKS

KW - INJURY

KW - PATHOGENESIS

U2 - 10.1183/13993003.02367-2016

DO - 10.1183/13993003.02367-2016

M3 - Original Article

C2 - 28775044

SN - 0903-1936

VL - 50

JO - EUROPEAN RESPIRATORY JOURNAL

JF - EUROPEAN RESPIRATORY JOURNAL

IS - 2

ER -

Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN et al. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis . EUROPEAN RESPIRATORY JOURNAL . 2017;50(2). doi: 10.1183/13993003.02367-2016