TY - JOUR
T1 - Seizure presentation and incidence-associated factors in treated cerebral arteriovenous malformations
T2 - a secondary analysis of the MISTA consortium
AU - Sconzo, Daniel
AU - Ramirez-Velandia, Felipe
AU - Muram, Sandeep
AU - Enriquez-Marulanda, Alejandro
AU - Adeeb, Nimer
AU - Kandregula, Sandeep
AU - Salim, Hamza Adel
AU - Musmar, Basel
AU - Dmytriw, Adam A.
AU - Kondziolka, Douglas
AU - Naamani, Kareem El
AU - Sheehan, Jason
AU - Ironside, Natasha
AU - Tos, Salem
AU - Abdelsalam, Ahmed
AU - Kumbhare, Deepak
AU - Ataoglu, Cagdas
AU - Essibayi, Muhammed Amir
AU - Keles, Abdullah
AU - Riina, Howard
AU - Rezai, Arwin
AU - Poeppe, Johannes
AU - Sen, Rajeev D.
AU - Griessenauer, Christoph J.
AU - Jabbour, Pascal
AU - Tjoumakaris, Stavropoula
AU - Burkhardt, Jan-Karl
AU - Starke, Robert M.
AU - Erginoglu, Ufuk
AU - Baskaya, Mustafa K.
AU - Sekhar, Laligam N.
AU - Levitt, Michael R.
AU - Altschul, David J.
AU - Mcavoy, Malia
AU - Aslan, Assala
AU - Abushehab, Abdallah
AU - Swaid, Christian
AU - Abla, Adib
AU - Stapleton, Christopher
AU - Koch, Matthew
AU - Srinivasan, Visish M.
AU - Chen, Peng R.
AU - Blackburn, Spiros
AU - Dannenbaum, Mark J.
AU - Choudhri, Omar
AU - Pukenas, Bryan
AU - Orbach, Darren
AU - Smith, Edward
AU - Moehlenbruch, Markus
AU - Alaraj, Ali
AU - Aziz-Sultan, Ali
AU - Patel, Aman B.
AU - Cuellar, Hugo H.
AU - Lawton, Michael
AU - Morcos, Jacques
AU - Guthikonda, Bharat
AU - Taussky, Philipp
AU - Ogilvy, Christopher S.
N1 - Rezai, Pöppe, Griessenauer: Department of Neurosurgery, Christian Doppler Klinik,
Paracelsus Medical University, Salzburg, Austria
PY - 2025/2/22
Y1 - 2025/2/22
N2 - Seizures occur in 20-45% of patients with cerebral arteriovenous malformations (AVMs) and can potentially influence their quality of life. Some studies have suggested risk factors influencing their development, but the evidence is limited to small cohorts. To analyze seizure presentation and factors influencing seizure development in patients with cerebral AVMs using a multi-institutional consortium. Retrospective multicenter registry from multiple centers in North America and Europe of patients aged 1 to 89 years who had undergone any intervention for brain AVMs between January 2010 and December 2023. Demographics, functional assessment (modified Rankin Scale; mRS), and AVM characteristics, were evaluated to assess for relationship with seizures using a multivariate generalized linear mixed-effects model. 1,005 AVM patients were analyzed; the median age was 42, 73% had a baseline mRS <= 2. The median nidus size was 2.2 cm, and most AVMs were Spetzler-Martin grade II (37%). Seizure was the presenting symptom in 237 patients (24%). After adjusting for significant variables, patient-specific factors associated with seizures were younger age (OR 0.99, CI95% 0.98-1), male sex (OR 1.65, CI95% 1.18-2.30), and smoking history (OR 1.69, CI95% 1.17-2.44). AVM-specific factors associated with seizures included rupture status (OR 0.42, CI95% 0.30-0.61); eloquent cortex (OR 1.61, CI95% 1.13-2.29); frontal (OR 1.54, CI95% 1.01-2.35), temporal (OR 1.93, CI95% 1.26-2.96) and parietal (OR 1.71 CI95% 1.08-2.71) location; larger nidal size (OR = 1.23, CI95% 1.08-1.39), and superficial draining vein location (OR 1.86, CI95% 1.15-3.01). In this multicenter consortium, after controlling for significant variables, the incidence of AVM-related seizures was associated with younger age, male sex, smoking history, larger AVMs, eloquent locations, and AVMs in the frontal, temporal, and parietal cortices. Conversely, rupture status, deep venous drainage, and cerebellar locations were negatively associated with seizures.
AB - Seizures occur in 20-45% of patients with cerebral arteriovenous malformations (AVMs) and can potentially influence their quality of life. Some studies have suggested risk factors influencing their development, but the evidence is limited to small cohorts. To analyze seizure presentation and factors influencing seizure development in patients with cerebral AVMs using a multi-institutional consortium. Retrospective multicenter registry from multiple centers in North America and Europe of patients aged 1 to 89 years who had undergone any intervention for brain AVMs between January 2010 and December 2023. Demographics, functional assessment (modified Rankin Scale; mRS), and AVM characteristics, were evaluated to assess for relationship with seizures using a multivariate generalized linear mixed-effects model. 1,005 AVM patients were analyzed; the median age was 42, 73% had a baseline mRS <= 2. The median nidus size was 2.2 cm, and most AVMs were Spetzler-Martin grade II (37%). Seizure was the presenting symptom in 237 patients (24%). After adjusting for significant variables, patient-specific factors associated with seizures were younger age (OR 0.99, CI95% 0.98-1), male sex (OR 1.65, CI95% 1.18-2.30), and smoking history (OR 1.69, CI95% 1.17-2.44). AVM-specific factors associated with seizures included rupture status (OR 0.42, CI95% 0.30-0.61); eloquent cortex (OR 1.61, CI95% 1.13-2.29); frontal (OR 1.54, CI95% 1.01-2.35), temporal (OR 1.93, CI95% 1.26-2.96) and parietal (OR 1.71 CI95% 1.08-2.71) location; larger nidal size (OR = 1.23, CI95% 1.08-1.39), and superficial draining vein location (OR 1.86, CI95% 1.15-3.01). In this multicenter consortium, after controlling for significant variables, the incidence of AVM-related seizures was associated with younger age, male sex, smoking history, larger AVMs, eloquent locations, and AVMs in the frontal, temporal, and parietal cortices. Conversely, rupture status, deep venous drainage, and cerebellar locations were negatively associated with seizures.
KW - Arteriovenous malformations
KW - Presentation
KW - Seizure
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pmu_pure&SrcAuth=WosAPI&KeyUT=WOS:001427884800001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1007/s10143-025-03337-z
DO - 10.1007/s10143-025-03337-z
M3 - Original Article
C2 - 39985590
SN - 0344-5607
VL - 48
JO - NEUROSURGICAL REVIEW
JF - NEUROSURGICAL REVIEW
IS - 1
M1 - 263
ER -