TY - CHAP
T1 - Retinal Biomarkers Discovery for Cerebral Small Vessel Disease in an Older Population
AU - Ballerini, Lucia
AU - Fetit, Ahmed E.
AU - Lovreglio, Ruggiero
AU - McGrory, Sarah
AU - Valdes-Hernandez, Maria
AU - MacGillivray, Tom
AU - Doubal, Fergus
AU - Deary, Ian J.
AU - Wardlaw, Joanna
AU - Trucco, Emanuele
A2 - Wunderlich, Stephan
N1 - Wunderlich: externe Aff.
PY - 2020/1
Y1 - 2020/1
N2 - The retinal and cerebral microvasculatures share many morphological and physiological properties. In this pilot we study the strength of the associations between morphological measurements of the retinal vasculature, obtained from fundus camera images, and of features of Small Vessel Disease (SVD), as white matter hyperintensities (WMH) and perivascular spaces (PVS), obtained from MRI brain scans. We performed a 500-trial bootstrap analysis with Regularized Gaussian linear regression on a cohort of older community-dwelling subjects (Lothian Birth Cohort 1936, N = 866) in their eighth decade. Arteriolar bifurcation coefficients, vessel tortuosity and fractal dimension predicted WMH volume in 23% of the trials. Arteriolar widths, venular bifurcation coefficients, and venular tortuosity predicted PVS in up to 99.6% of the trials.
AB - The retinal and cerebral microvasculatures share many morphological and physiological properties. In this pilot we study the strength of the associations between morphological measurements of the retinal vasculature, obtained from fundus camera images, and of features of Small Vessel Disease (SVD), as white matter hyperintensities (WMH) and perivascular spaces (PVS), obtained from MRI brain scans. We performed a 500-trial bootstrap analysis with Regularized Gaussian linear regression on a cohort of older community-dwelling subjects (Lothian Birth Cohort 1936, N = 866) in their eighth decade. Arteriolar bifurcation coefficients, vessel tortuosity and fractal dimension predicted WMH volume in 23% of the trials. Arteriolar widths, venular bifurcation coefficients, and venular tortuosity predicted PVS in up to 99.6% of the trials.
KW - Biomarkers
KW - Retina
KW - Small vessel disease
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pmu_pure&SrcAuth=WosAPI&KeyUT=WOS:000770412700031&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1007/978-3-030-52791-4_31
DO - 10.1007/978-3-030-52791-4_31
M3 - Chapter
VL - 1248
T3 - Communications In Computer And Information Science
SP - 400
EP - 409
BT - Medical Image Understanding and Analysis
PB - Springer
T2 - 24th Conference on Medical Image Understanding and Analysis (MIUA)
Y2 - 15 July 2020 through 17 July 2020
ER -