Rethinking virulence screening in Klebsiella pneumoniae: a case for a standardised Galleria mellonella infection model

Katharina Schaufler; Nicola Schmidt; Michael Schwabe; Stefan E Heiden; Helmut Fickenscher; Pei Yee Woh; Sy Bui Tien; Thirumalaisamy P Velavan; Le Huu Song; Bernd Neumann; Evgeny A Idelevich; Karsten Becker; Andi Krumbholz; Kaan Kocer; Sébastien Boutin; Dennis Nurjadi; Elias Eger

doi:10.1016/j.lanmic.2026.101421

Rethinking virulence screening in Klebsiella pneumoniae: a case for a standardised Galleria mellonella infection model

Katharina Schaufler
, Nicola Schmidt
, Michael Schwabe
, Stefan E Heiden
, Helmut Fickenscher
, Pei Yee Woh
, Sy Bui Tien
, Thirumalaisamy P Velavan
, Le Huu Song
, Bernd Neumann (Co-author)
, Evgeny A Idelevich
, Karsten Becker
, Andi Krumbholz
, Kaan Kocer
, Sébastien Boutin
, Dennis Nurjadi
, Elias Eger

Institute of Laboratory Medicine and Infectious Diseases

University Medicine Greifswald
Helmholtz Institute for One Health
Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein
VinUniversity
Department of Medical Microbiology
Duy Tan University
formerly University of Tübingen
University Hospital Münster
University of Lübeck and University Medical Center Schleswig-Holstein Campus Lübeck

Research output: Contribution to journal › Case report › peer-review

Original language	English
Pages (from-to)	101421
Journal	The Lancet. Microbe
DOIs	https://doi.org/10.1016/j.lanmic.2026.101421
Publication status	E-pub ahead of print - 28 Apr 2026

Access to Document

10.1016/j.lanmic.2026.101421

Cite this

Schaufler, K., Schmidt, N., Schwabe, M., Heiden, S. E., Fickenscher, H., Woh, P. Y., Tien, S. B., Velavan, T. P., Song, L. H., Neumann, B., Idelevich, E. A., Becker, K., Krumbholz, A., Kocer, K., Boutin, S., Nurjadi, D., & Eger, E. (2026). Rethinking virulence screening in Klebsiella pneumoniae: a case for a standardised Galleria mellonella infection model. The Lancet. Microbe, 101421. Advance online publication. https://doi.org/10.1016/j.lanmic.2026.101421

@article{9e83cb4fe9c145b8b75890a6469142e5,

title = "Rethinking virulence screening in Klebsiella pneumoniae: a case for a standardised Galleria mellonella infection model",

author = "Katharina Schaufler and Nicola Schmidt and Michael Schwabe and Heiden, \{Stefan E\} and Helmut Fickenscher and Woh, \{Pei Yee\} and Tien, \{Sy Bui\} and Velavan, \{Thirumalaisamy P\} and Song, \{Le Huu\} and Bernd Neumann and Idelevich, \{Evgeny A\} and Karsten Becker and Andi Krumbholz and Kaan Kocer and S{\'e}bastien Boutin and Dennis Nurjadi and Elias Eger",

note = "Neumann: Institute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany",

year = "2026",

month = apr,

day = "28",

doi = "10.1016/j.lanmic.2026.101421",

language = "English",

pages = "101421",

journal = "The Lancet. Microbe",

issn = "2666-5247",

}

Schaufler, K, Schmidt, N, Schwabe, M, Heiden, SE, Fickenscher, H, Woh, PY, Tien, SB, Velavan, TP, Song, LH, Neumann, B, Idelevich, EA, Becker, K, Krumbholz, A, Kocer, K, Boutin, S, Nurjadi, D & Eger, E 2026, 'Rethinking virulence screening in Klebsiella pneumoniae: a case for a standardised Galleria mellonella infection model', The Lancet. Microbe, pp. 101421. https://doi.org/10.1016/j.lanmic.2026.101421

TY - JOUR

T1 - Rethinking virulence screening in Klebsiella pneumoniae

T2 - a case for a standardised Galleria mellonella infection model

AU - Schaufler, Katharina

AU - Schmidt, Nicola

AU - Schwabe, Michael

AU - Heiden, Stefan E

AU - Fickenscher, Helmut

AU - Woh, Pei Yee

AU - Tien, Sy Bui

AU - Velavan, Thirumalaisamy P

AU - Song, Le Huu

AU - Neumann, Bernd

AU - Idelevich, Evgeny A

AU - Becker, Karsten

AU - Krumbholz, Andi

AU - Kocer, Kaan

AU - Boutin, Sébastien

AU - Nurjadi, Dennis

AU - Eger, Elias

N1 - Neumann: Institute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany

PY - 2026/4/28

Y1 - 2026/4/28

U2 - 10.1016/j.lanmic.2026.101421

DO - 10.1016/j.lanmic.2026.101421

M3 - Case report

C2 - 42066787

SN - 2666-5247

SP - 101421

JO - The Lancet. Microbe

JF - The Lancet. Microbe

ER -