Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer.

A-R Hanauske; M Lahn; L C Musib; K Weigang-Köhler; E Yilmaz; T Graefe; B Kuenen; D Thornton; P McNealy; G Giaccone

doi:10.1093/annonc/mdp049

Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer.

A-R Hanauske
, M Lahn
, L C Musib
, K Weigang-Köhler
, E Yilmaz
, T Graefe
, B Kuenen
, D Thornton
, P McNealy
, G Giaccone

Department of Internal Medicine V, Division of Oncology and Hematology

Research output: Contribution to journal › Original Article › peer-review

22 Citations (Web of Science)

Original language	English
Pages (from-to)	156-175
Journal	ANNALS OF ONCOLOGY
Volume	20
Issue number	9
DOIs	https://doi.org/10.1093/annonc/mdp049
Publication status	Published - 2009

Keywords

KINASE-C-BETA
CELL LUNG-CANCER
INHIBITOR ENZASTAURIN
IN-VITRO
MULTITARGETED ANTIFOLATE
SELECTIVE INHIBITOR
DOSE-ESCALATION
ONCOLOGY TRIALS
THYROID-CANCER
SOLID TUMORS

Access to Document

10.1093/annonc/mdp049

Cite this

Hanauske, A.-R., Lahn, M., Musib, L. C., Weigang-Köhler, K., Yilmaz, E., Graefe, T., Kuenen, B., Thornton, D., McNealy, P., & Giaccone, G. (2009). Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer. ANNALS OF ONCOLOGY , 20(9), 156-175. https://doi.org/10.1093/annonc/mdp049

Hanauske, A-R ; Lahn, M ; Musib, L C et al. / Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer. In: ANNALS OF ONCOLOGY 2009 ; Vol. 20, No. 9. pp. 156-175.

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Hanauske, A-R, Lahn, M, Musib, LC, Weigang-Köhler, K, Yilmaz, E, Graefe, T, Kuenen, B, Thornton, D, McNealy, P & Giaccone, G 2009, 'Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer.', ANNALS OF ONCOLOGY , vol. 20, no. 9, pp. 156-175. https://doi.org/10.1093/annonc/mdp049

Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer. / Hanauske, A-R; Lahn, M; Musib, L C et al.
In: ANNALS OF ONCOLOGY , Vol. 20, No. 9, 2009, p. 156-175.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer.

AU - Hanauske, A-R

AU - Lahn, M

AU - Musib, L C

AU - Weigang-Köhler, K

AU - Yilmaz, E

AU - Graefe, T

AU - Kuenen, B

AU - Thornton, D

AU - McNealy, P

AU - Giaccone, G

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KW - INHIBITOR ENZASTAURIN

KW - IN-VITRO

KW - MULTITARGETED ANTIFOLATE

KW - SELECTIVE INHIBITOR

KW - DOSE-ESCALATION

KW - ONCOLOGY TRIALS

KW - THYROID-CANCER

KW - SOLID TUMORS

U2 - 10.1093/annonc/mdp049

DO - 10.1093/annonc/mdp049

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C2 - 19487488

SN - 0923-7534

VL - 20

SP - 156

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JO - ANNALS OF ONCOLOGY

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Hanauske AR, Lahn M, Musib LC, Weigang-Köhler K, Yilmaz E, Graefe T et al. Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer. ANNALS OF ONCOLOGY . 2009;20(9):156-175. doi: 10.1093/annonc/mdp049