Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

Muhammad Akram; Watcharee Waratchareeyakul; Joerg Haupenthal; Rolf W Hartmann; Daniela Brigitte Schuster

doi:10.3389/fchem.2017.00104

Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

Muhammad Akram (First author), Watcharee Waratchareeyakul, Joerg Haupenthal, Rolf W Hartmann, Daniela Brigitte Schuster^* (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article › peer-review

12 Citations (Web of Science)

Original language	English
Pages (from-to)	104
Journal	FRONTIERS IN CHEMISTRY
Volume	5
DOIs	https://doi.org/10.3389/fchem.2017.00104
Publication status	Published - 2017

Keywords

ALDOSTERONE SYNTHASE CYP11B2
CONGESTIVE-HEART-FAILURE
STRUCTURALLY MODIFIED DERIVATIVES
CORTISOL-DEPENDENT DISEASES
CHINESE-HAMSTER CELLS
PROTEIN DATA-BANK
MYOCARDIAL FIBROSIS
SELECTIVE INHIBITORS
CUSHINGS-SYNDROME
DUAL INHIBITORS

Access to Document

10.3389/fchem.2017.00104

Cite this

@article{a8804cc9466548a18f031b3a1b0733eb,

title = "Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors",

keywords = "ALDOSTERONE SYNTHASE CYP11B2, CONGESTIVE-HEART-FAILURE, STRUCTURALLY MODIFIED DERIVATIVES, CORTISOL-DEPENDENT DISEASES, CHINESE-HAMSTER CELLS, PROTEIN DATA-BANK, MYOCARDIAL FIBROSIS, SELECTIVE INHIBITORS, CUSHINGS-SYNDROME, DUAL INHIBITORS",

author = "Muhammad Akram and Watcharee Waratchareeyakul and Joerg Haupenthal and Hartmann, {Rolf W} and Schuster, {Daniela Brigitte}",

note = "all:Department of Radiology and Nuclear Medicine, Klinikum Nuremberg, Nuremberg, Germany",

year = "2017",

doi = "10.3389/fchem.2017.00104",

language = "English",

volume = "5",

pages = "104",

journal = "FRONTIERS IN CHEMISTRY",

issn = "2296-2646",

}

TY - JOUR

T1 - Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

AU - Akram, Muhammad

AU - Waratchareeyakul, Watcharee

AU - Haupenthal, Joerg

AU - Hartmann, Rolf W

AU - Schuster, Daniela Brigitte

N1 - all:Department of Radiology and Nuclear Medicine, Klinikum Nuremberg, Nuremberg, Germany

PY - 2017

Y1 - 2017

KW - ALDOSTERONE SYNTHASE CYP11B2

KW - CONGESTIVE-HEART-FAILURE

KW - STRUCTURALLY MODIFIED DERIVATIVES

KW - CORTISOL-DEPENDENT DISEASES

KW - CHINESE-HAMSTER CELLS

KW - PROTEIN DATA-BANK

KW - MYOCARDIAL FIBROSIS

KW - SELECTIVE INHIBITORS

KW - CUSHINGS-SYNDROME

KW - DUAL INHIBITORS

U2 - 10.3389/fchem.2017.00104

DO - 10.3389/fchem.2017.00104

M3 - Original Article

C2 - 29312923

SN - 2296-2646

VL - 5

SP - 104

JO - FRONTIERS IN CHEMISTRY

JF - FRONTIERS IN CHEMISTRY

ER -