Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

Ulrike Garscha; Erik Romp; Simona Pace; Antonietta Rossi; Veronika Temml; Daniela Brigitte Schuster; Stefanie König; Jana Gerstmeier; Stefanie Liening; Markus Werner; Heiner Atze; Sandra Wittmann; Christina Weinigel; Silke Rummler; Gerhard K Scriba; Lidia Sautebin; Oliver Werz

doi:10.1038/s41598-017-09795-w

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

Ulrike Garscha, Erik Romp, Simona Pace, Antonietta Rossi, Veronika Temml, Daniela Brigitte Schuster (Co-author), Stefanie König, Jana Gerstmeier, Stefanie Liening, Markus Werner, Heiner Atze, Sandra Wittmann, Christina Weinigel, Silke Rummler, Gerhard K Scriba, Lidia Sautebin, Oliver Werz

Insitute of Pharmacy

Research output: Contribution to journal › Original Article › peer-review

32 Citations (Web of Science)

Original language	English
Pages (from-to)	9398
Journal	Scientific reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-09795-w
Publication status	Published - 2017

Keywords

LEUKOTRIENE C-4 SYNTHASE
ARACHIDONIC-ACID
ANTIINFLAMMATORY DRUGS
MOLECULAR-MECHANISM
MEMBRANE-PROTEIN
BIOSYNTHESIS
METABOLISM
FLAP
DISCOVERY
INFLAMMATION

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10.1038/s41598-017-09795-w

Cite this

Garscha, U., Romp, E., Pace, S., Rossi, A., Temml, V., Schuster, D. B., König, S., Gerstmeier, J., Liening, S., Werner, M., Atze, H., Wittmann, S., Weinigel, C., Rummler, S., Scriba, G. K., Sautebin, L., & Werz, O. (2017). Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Scientific reports, 7(1), 9398. https://doi.org/10.1038/s41598-017-09795-w

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title = "Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.",

keywords = "LEUKOTRIENE C-4 SYNTHASE, ARACHIDONIC-ACID, ANTIINFLAMMATORY DRUGS, MOLECULAR-MECHANISM, MEMBRANE-PROTEIN, BIOSYNTHESIS, METABOLISM, FLAP, DISCOVERY, INFLAMMATION",

author = "Ulrike Garscha and Erik Romp and Simona Pace and Antonietta Rossi and Veronika Temml and Schuster, {Daniela Brigitte} and Stefanie K{\"o}nig and Jana Gerstmeier and Stefanie Liening and Markus Werner and Heiner Atze and Sandra Wittmann and Christina Weinigel and Silke Rummler and Scriba, {Gerhard K} and Lidia Sautebin and Oliver Werz",

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doi = "10.1038/s41598-017-09795-w",

language = "English",

volume = "7",

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Garscha, U, Romp, E, Pace, S, Rossi, A, Temml, V , Schuster, DB, König, S, Gerstmeier, J, Liening, S, Werner, M, Atze, H, Wittmann, S, Weinigel, C, Rummler, S, Scriba, GK, Sautebin, L & Werz, O 2017, 'Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.', Scientific reports, vol. 7, no. 1, pp. 9398. https://doi.org/10.1038/s41598-017-09795-w

TY - JOUR

T1 - Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

AU - Garscha, Ulrike

AU - Romp, Erik

AU - Pace, Simona

AU - Rossi, Antonietta

AU - Temml, Veronika

AU - Schuster, Daniela Brigitte

AU - König, Stefanie

AU - Gerstmeier, Jana

AU - Liening, Stefanie

AU - Werner, Markus

AU - Atze, Heiner

AU - Wittmann, Sandra

AU - Weinigel, Christina

AU - Rummler, Silke

AU - Scriba, Gerhard K

AU - Sautebin, Lidia

AU - Werz, Oliver

PY - 2017

Y1 - 2017

KW - LEUKOTRIENE C-4 SYNTHASE

KW - ARACHIDONIC-ACID

KW - ANTIINFLAMMATORY DRUGS

KW - MOLECULAR-MECHANISM

KW - MEMBRANE-PROTEIN

KW - BIOSYNTHESIS

KW - METABOLISM

KW - FLAP

KW - DISCOVERY

KW - INFLAMMATION

U2 - 10.1038/s41598-017-09795-w

DO - 10.1038/s41598-017-09795-w

M3 - Original Article

C2 - 28839250

SN - 2045-2322

VL - 7

SP - 9398

JO - Scientific reports

JF - Scientific reports

IS - 1

ER -