Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience

Matthias Mattke; Matteo Ohlinger; Nina Bougatf; Robert Wolf; Thomas Welzel; Falk Röder; Sabine Gerum; Christoph Fussl; Natalee Annon-Eberharter; Malte Ellerbrock; Oliver Jäkel; Thomas Haberer; Klaus Herfarth; Matthias Uhl; Jürgen Debus; Katharina Seidensaal; Semi Harrabi

doi:10.3390/cancers16040718

Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience

Matthias Mattke^* (First author), Matteo Ohlinger (Co-author), Nina Bougatf (Co-author), Robert Wolf (Co-author), Thomas Welzel (Co-author), Falk Röder (Co-author), Sabine Gerum (Co-author), Christoph Fussl (Co-author), Natalee Annon-Eberharter (Co-author), Malte Ellerbrock (Co-author), Oliver Jäkel (Co-author), Thomas Haberer (Co-author), Klaus Herfarth (Co-author), Matthias Uhl (Co-author), Jürgen Debus (Co-author), Katharina Seidensaal (Last author), Semi Harrabi (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article (Journal) › peer-review

Abstract

Background: The current study aims to evaluate the occurrence of temporal lobe reactions and identify possible risk factors for patients who underwent particle therapy of the skull base.

Methods: 244 patients treated for skull base chordoma (n = 144) or chondrosarcoma (n = 100) at the Heidelberg Ion Beam Therapy Center (HIT) using a raster scan technique, were analyzed. Follow-up MRI-scans were matched with the initial planning images. Radiogenic reactions were contoured and analyzed based on volume and dose of treatment.

Results: 51 patients with chordoma (35.4%) and 30 patients (30%) with chondrosarcoma experienced at least one temporal lobe reaction within the follow-up period (median 49 months for chondrosarcoma, 62 months for chordoma). Age, irradiated volume, and dose values were significant risk factors for the development of temporal lobe reactions with the highest significance for the value of DMax-7 being defined as the dose maximum in the temporal lobe minus the 7cc with the highest dose (p = 0.000000000019; OR 1.087).

Conclusion: Temporal lobe reactions are a common side effect after particle therapy of the skull base. We were able to develop a multivariate model, which predicted radiation reactions with a specificity of 99% and a sensitivity of 52.2%.

Original language	English
Journal	Cancers
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/cancers16040718
Publication status	Published - 8 Feb 2024

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Mattke, M., Ohlinger, M., Bougatf, N., Wolf, R., Welzel, T., Röder, F., Gerum, S., Fussl , C., Annon-Eberharter, N., Ellerbrock, M., Jäkel, O., Haberer, T., Herfarth, K., Uhl, M., Debus, J., Seidensaal, K., & Harrabi, S. (2024). Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience. Cancers, 16(4). https://doi.org/10.3390/cancers16040718

@article{41b486fce2c94817b131ee99e91f8a44,

title = "Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience",

abstract = "Background: The current study aims to evaluate the occurrence of temporal lobe reactions and identify possible risk factors for patients who underwent particle therapy of the skull base.Methods: 244 patients treated for skull base chordoma (n = 144) or chondrosarcoma (n = 100) at the Heidelberg Ion Beam Therapy Center (HIT) using a raster scan technique, were analyzed. Follow-up MRI-scans were matched with the initial planning images. Radiogenic reactions were contoured and analyzed based on volume and dose of treatment.Results: 51 patients with chordoma (35.4%) and 30 patients (30%) with chondrosarcoma experienced at least one temporal lobe reaction within the follow-up period (median 49 months for chondrosarcoma, 62 months for chordoma). Age, irradiated volume, and dose values were significant risk factors for the development of temporal lobe reactions with the highest significance for the value of DMax-7 being defined as the dose maximum in the temporal lobe minus the 7cc with the highest dose (p = 0.000000000019; OR 1.087).Conclusion: Temporal lobe reactions are a common side effect after particle therapy of the skull base. We were able to develop a multivariate model, which predicted radiation reactions with a specificity of 99% and a sensitivity of 52.2%.",

author = "Matthias Mattke and Matteo Ohlinger and Nina Bougatf and Robert Wolf and Thomas Welzel and Falk R{\"o}der and Sabine Gerum and Christoph Fussl and Natalee Annon-Eberharter and Malte Ellerbrock and Oliver J{\"a}kel and Thomas Haberer and Klaus Herfarth and Matthias Uhl and J{\"u}rgen Debus and Katharina Seidensaal and Semi Harrabi",

note = "Mattke, R{\"o}der, Gerum, Fussl, Annon-Eberharter: Department of Radiation Oncology, Paracelsus Medical University, Salzburger Landesklinikum (SALK); R{\"o}der: Institute of Research and Development of Advanced Radiation Technologies (radART), Paracelsus Medical University, 5020 Salzburg, Austria",

year = "2024",

month = feb,

day = "8",

doi = "10.3390/cancers16040718",

language = "English",

volume = "16",

journal = "Cancers",

issn = "2072-6694",

publisher = "MDPI",

number = "4",

}

Mattke, M, Ohlinger, M, Bougatf, N, Wolf, R, Welzel, T, Röder, F , Gerum, S , Fussl , C, Annon-Eberharter, N, Ellerbrock, M, Jäkel, O, Haberer, T, Herfarth, K, Uhl, M, Debus, J, Seidensaal, K & Harrabi, S 2024, 'Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience', Cancers, vol. 16, no. 4. https://doi.org/10.3390/cancers16040718

Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience. / Mattke, Matthias (First author); Ohlinger, Matteo (Co-author); Bougatf, Nina (Co-author) et al.
In: Cancers, Vol. 16, No. 4, 08.02.2024.

Research output: Contribution to journal › Original Article (Journal) › peer-review

TY - JOUR

T1 - Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience

AU - Mattke, Matthias

AU - Ohlinger, Matteo

AU - Bougatf, Nina

AU - Wolf, Robert

AU - Welzel, Thomas

AU - Röder, Falk

AU - Gerum, Sabine

AU - Fussl , Christoph

AU - Annon-Eberharter, Natalee

AU - Ellerbrock, Malte

AU - Jäkel, Oliver

AU - Haberer, Thomas

AU - Herfarth, Klaus

AU - Uhl, Matthias

AU - Debus, Jürgen

AU - Seidensaal, Katharina

AU - Harrabi, Semi

N1 - Mattke, Röder, Gerum, Fussl, Annon-Eberharter: Department of Radiation Oncology, Paracelsus Medical University, Salzburger Landesklinikum (SALK); Röder: Institute of Research and Development of Advanced Radiation Technologies (radART), Paracelsus Medical University, 5020 Salzburg, Austria

PY - 2024/2/8

Y1 - 2024/2/8

N2 - Background: The current study aims to evaluate the occurrence of temporal lobe reactions and identify possible risk factors for patients who underwent particle therapy of the skull base.Methods: 244 patients treated for skull base chordoma (n = 144) or chondrosarcoma (n = 100) at the Heidelberg Ion Beam Therapy Center (HIT) using a raster scan technique, were analyzed. Follow-up MRI-scans were matched with the initial planning images. Radiogenic reactions were contoured and analyzed based on volume and dose of treatment.Results: 51 patients with chordoma (35.4%) and 30 patients (30%) with chondrosarcoma experienced at least one temporal lobe reaction within the follow-up period (median 49 months for chondrosarcoma, 62 months for chordoma). Age, irradiated volume, and dose values were significant risk factors for the development of temporal lobe reactions with the highest significance for the value of DMax-7 being defined as the dose maximum in the temporal lobe minus the 7cc with the highest dose (p = 0.000000000019; OR 1.087).Conclusion: Temporal lobe reactions are a common side effect after particle therapy of the skull base. We were able to develop a multivariate model, which predicted radiation reactions with a specificity of 99% and a sensitivity of 52.2%.

AB - Background: The current study aims to evaluate the occurrence of temporal lobe reactions and identify possible risk factors for patients who underwent particle therapy of the skull base.Methods: 244 patients treated for skull base chordoma (n = 144) or chondrosarcoma (n = 100) at the Heidelberg Ion Beam Therapy Center (HIT) using a raster scan technique, were analyzed. Follow-up MRI-scans were matched with the initial planning images. Radiogenic reactions were contoured and analyzed based on volume and dose of treatment.Results: 51 patients with chordoma (35.4%) and 30 patients (30%) with chondrosarcoma experienced at least one temporal lobe reaction within the follow-up period (median 49 months for chondrosarcoma, 62 months for chordoma). Age, irradiated volume, and dose values were significant risk factors for the development of temporal lobe reactions with the highest significance for the value of DMax-7 being defined as the dose maximum in the temporal lobe minus the 7cc with the highest dose (p = 0.000000000019; OR 1.087).Conclusion: Temporal lobe reactions are a common side effect after particle therapy of the skull base. We were able to develop a multivariate model, which predicted radiation reactions with a specificity of 99% and a sensitivity of 52.2%.

U2 - 10.3390/cancers16040718

DO - 10.3390/cancers16040718

M3 - Original Article (Journal)

C2 - 38398109

SN - 2072-6694

VL - 16

JO - Cancers

JF - Cancers

IS - 4

ER -

Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma-A Single-Center Experience

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