Normothermic machine perfusion of the kidney

Annemarie Weissenbacher; James Hunter

doi:10.1097/MOT.0000000000000470

Normothermic machine perfusion of the kidney

Annemarie Weissenbacher^* (First author)
, James Hunter

^*Corresponding author for this work

Presidents Office

Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Churchill Hospital, Oxford, United Kingdom
Department for Visceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria

Research output: Contribution to journal › Review article › peer-review

Abstract

PURPOSE OF REVIEW: Normothermic machine perfusion (NMP) is a preservation method that is generating increasing interest. The aim of this review is to summarise the current status of NMP in regards of kidney viability assessment, reducing organ damage and improving transplant logistics.

RECENT FINDINGS: The results of recent large animal experiments and clinical trials show that continuous prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP after static cold storage in terms of renal injury and function. A recently developed clinical scoring system appears to correlate with renal and tubular function. A prospective clinical phase II trial to investigate the initial graft function after 1 h of NMP or static cold storage in kidneys from donors after circulatory death has been initiated in the United Kingdom.

SUMMARY: Progress has been made in normothermic kidney perfusion, mainly in experimental settings. These results need to be translated into clinical trials to evaluate long-term NMP and its impact in human organs. Future investigations of optimal perfusion parameters are needed.

Original language	English
Pages (from-to)	571-576
Number of pages	6
Journal	Current opinion in organ transplantation
Volume	22
Issue number	6
DOIs	https://doi.org/10.1097/MOT.0000000000000470
Publication status	Published - Dec 2017

Keywords

Animals
Humans
Kidney/metabolism
Kidney Transplantation/methods
Organ Preservation/methods
Perfusion/methods
Prospective Studies

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10.1097/MOT.0000000000000470

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title = "Normothermic machine perfusion of the kidney",

abstract = "PURPOSE OF REVIEW: Normothermic machine perfusion (NMP) is a preservation method that is generating increasing interest. The aim of this review is to summarise the current status of NMP in regards of kidney viability assessment, reducing organ damage and improving transplant logistics.RECENT FINDINGS: The results of recent large animal experiments and clinical trials show that continuous prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP after static cold storage in terms of renal injury and function. A recently developed clinical scoring system appears to correlate with renal and tubular function. A prospective clinical phase II trial to investigate the initial graft function after 1 h of NMP or static cold storage in kidneys from donors after circulatory death has been initiated in the United Kingdom.SUMMARY: Progress has been made in normothermic kidney perfusion, mainly in experimental settings. These results need to be translated into clinical trials to evaluate long-term NMP and its impact in human organs. Future investigations of optimal perfusion parameters are needed.",

keywords = "Animals, Humans, Kidney/metabolism, Kidney Transplantation/methods, Organ Preservation/methods, Perfusion/methods, Prospective Studies",

author = "Annemarie Weissenbacher and James Hunter",

note = "Weissenbacher: Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Churchill Hospital, Oxford, United Kingdom bDepartment for Visceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria",

year = "2017",

month = dec,

doi = "10.1097/MOT.0000000000000470",

language = "English",

volume = "22",

pages = "571--576",

journal = "Current opinion in organ transplantation",

issn = "1087-2418",

number = "6",

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T1 - Normothermic machine perfusion of the kidney

AU - Weissenbacher, Annemarie

AU - Hunter, James

N1 - Weissenbacher: Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Churchill Hospital, Oxford, United Kingdom bDepartment for Visceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria

PY - 2017/12

Y1 - 2017/12

N2 - PURPOSE OF REVIEW: Normothermic machine perfusion (NMP) is a preservation method that is generating increasing interest. The aim of this review is to summarise the current status of NMP in regards of kidney viability assessment, reducing organ damage and improving transplant logistics.RECENT FINDINGS: The results of recent large animal experiments and clinical trials show that continuous prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP after static cold storage in terms of renal injury and function. A recently developed clinical scoring system appears to correlate with renal and tubular function. A prospective clinical phase II trial to investigate the initial graft function after 1 h of NMP or static cold storage in kidneys from donors after circulatory death has been initiated in the United Kingdom.SUMMARY: Progress has been made in normothermic kidney perfusion, mainly in experimental settings. These results need to be translated into clinical trials to evaluate long-term NMP and its impact in human organs. Future investigations of optimal perfusion parameters are needed.

AB - PURPOSE OF REVIEW: Normothermic machine perfusion (NMP) is a preservation method that is generating increasing interest. The aim of this review is to summarise the current status of NMP in regards of kidney viability assessment, reducing organ damage and improving transplant logistics.RECENT FINDINGS: The results of recent large animal experiments and clinical trials show that continuous prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP after static cold storage in terms of renal injury and function. A recently developed clinical scoring system appears to correlate with renal and tubular function. A prospective clinical phase II trial to investigate the initial graft function after 1 h of NMP or static cold storage in kidneys from donors after circulatory death has been initiated in the United Kingdom.SUMMARY: Progress has been made in normothermic kidney perfusion, mainly in experimental settings. These results need to be translated into clinical trials to evaluate long-term NMP and its impact in human organs. Future investigations of optimal perfusion parameters are needed.

KW - Animals

KW - Humans

KW - Kidney/metabolism

KW - Kidney Transplantation/methods

KW - Organ Preservation/methods

KW - Perfusion/methods

KW - Prospective Studies

U2 - 10.1097/MOT.0000000000000470

DO - 10.1097/MOT.0000000000000470

M3 - Review article

C2 - 28901972

SN - 1087-2418

VL - 22

SP - 571

EP - 576

JO - Current opinion in organ transplantation

JF - Current opinion in organ transplantation

IS - 6

ER -

Normothermic machine perfusion of the kidney

Abstract

Keywords

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