Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease.

Marius Wernig; Jian-Ping Zhao; Jan Pruszak; Eva Hedlund; Dongdong Fu; Frank Soldner; Vania Broccoli; Martha Constantine-Paton; Ole Isacson; Rudolf Jaenisch

doi:10.1073/pnas.0801677105

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease.

Marius Wernig, Jian-Ping Zhao, Jan Pruszak, Eva Hedlund, Dongdong Fu, Frank Soldner, Vania Broccoli, Martha Constantine-Paton, Ole Isacson, Rudolf Jaenisch

Research output: Contribution to journal › Original Article › peer-review

850 Citations (Web of Science)

Original language	English
Pages (from-to)	585-561
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume	105
Issue number	15
DOIs	https://doi.org/10.1073/pnas.0801677105
Publication status	Published - 2008

Keywords

EMBRYONIC STEM-CELLS
DOPAMINERGIC-NEURONS
SUBSTANTIA-NIGRA
IN-VITRO
NUCLEAR TRANSPLANTATION
MIDBRAIN
THERAPY
MODEL
POPULATIONS
EXPRESSION

Access to Document

10.1073/pnas.0801677105

Cite this

Wernig, M., Zhao, J.-P., Pruszak, J., Hedlund, E., Fu, D., Soldner, F., Broccoli, V., Constantine-Paton, M., Isacson, O., & Jaenisch, R. (2008). Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 105(15), 585-561. https://doi.org/10.1073/pnas.0801677105

Wernig, Marius ; Zhao, Jian-Ping ; Pruszak, Jan et al. / Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease. In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008 ; Vol. 105, No. 15. pp. 585-561.

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title = "Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease.",

keywords = "EMBRYONIC STEM-CELLS, DOPAMINERGIC-NEURONS, SUBSTANTIA-NIGRA, IN-VITRO, NUCLEAR TRANSPLANTATION, MIDBRAIN, THERAPY, MODEL, POPULATIONS, EXPRESSION",

author = "Marius Wernig and Jian-Ping Zhao and Jan Pruszak and Eva Hedlund and Dongdong Fu and Frank Soldner and Vania Broccoli and Martha Constantine-Paton and Ole Isacson and Rudolf Jaenisch",

year = "2008",

doi = "10.1073/pnas.0801677105",

language = "English",

volume = "105",

pages = "585--561",

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Wernig, M, Zhao, J-P, Pruszak, J, Hedlund, E, Fu, D, Soldner, F, Broccoli, V, Constantine-Paton, M, Isacson, O & Jaenisch, R 2008, 'Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease.', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , vol. 105, no. 15, pp. 585-561. https://doi.org/10.1073/pnas.0801677105

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease. / Wernig, Marius; Zhao, Jian-Ping; Pruszak, Jan et al.
In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , Vol. 105, No. 15, 2008, p. 585-561.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease.

AU - Wernig, Marius

AU - Zhao, Jian-Ping

AU - Pruszak, Jan

AU - Hedlund, Eva

AU - Fu, Dongdong

AU - Soldner, Frank

AU - Broccoli, Vania

AU - Constantine-Paton, Martha

AU - Isacson, Ole

AU - Jaenisch, Rudolf

PY - 2008

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KW - DOPAMINERGIC-NEURONS

KW - SUBSTANTIA-NIGRA

KW - IN-VITRO

KW - NUCLEAR TRANSPLANTATION

KW - MIDBRAIN

KW - THERAPY

KW - MODEL

KW - POPULATIONS

KW - EXPRESSION

U2 - 10.1073/pnas.0801677105

DO - 10.1073/pnas.0801677105

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C2 - 18391196

SN - 0027-8424

VL - 105

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EP - 561

JO - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinsons disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA . 2008;105(15):585-561. doi: 10.1073/pnas.0801677105