MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.

K J Ahlqvist; S Leoncini; A Pecorelli; Saskia Wortmann; S Ahola; S Forsström; R Guerranti; C De Felice; J Smeitink; L Ciccoli; R H Hämäläinen; A Suomalainen

doi:10.1038/ncomms7494

MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.

K J Ahlqvist, S Leoncini, A Pecorelli, Saskia Wortmann (Co-author), S Ahola, S Forsström, R Guerranti, C De Felice, J Smeitink, L Ciccoli, R H Hämäläinen, A Suomalainen

Research output: Contribution to journal › Original Article › peer-review

48 Citations (Web of Science)

Original language	English
Pages (from-to)	6494
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7494
Publication status	Published - 2015

Keywords

OXIDATIVE STRESS
RETICULOCYTE MATURATION
MUTATOR MICE
IN-VIVO
INDEPENDENT MECHANISMS
ORGANELLE DEGRADATION
DNA DELETION
CLEARANCE
ANEMIA
CELLS

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10.1038/ncomms7494

Cite this

Ahlqvist, K. J., Leoncini, S., Pecorelli, A., Wortmann, S., Ahola, S., Forsström, S., Guerranti, R., De Felice, C., Smeitink, J., Ciccoli, L., Hämäläinen, R. H., & Suomalainen, A. (2015). MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction. Nature Communications, 6, 6494. https://doi.org/10.1038/ncomms7494

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title = "MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.",

keywords = "OXIDATIVE STRESS, RETICULOCYTE MATURATION, MUTATOR MICE, IN-VIVO, INDEPENDENT MECHANISMS, ORGANELLE DEGRADATION, DNA DELETION, CLEARANCE, ANEMIA, CELLS",

author = "Ahlqvist, {K J} and S Leoncini and A Pecorelli and Saskia Wortmann and S Ahola and S Forsstr{\"o}m and R Guerranti and {De Felice}, C and J Smeitink and L Ciccoli and H{\"a}m{\"a}l{\"a}inen, {R H} and A Suomalainen",

note = "Ahlqvist, KJ [1]; Leoncini, S [2,3]; Pecorelli, A [2,3]; Wortmann, SB [4]; Ahola, S [1]; Forsstrom, S [1]; Guerranti, R [5,6]; De Felice, C [7]; Smeitink, J ; Ciccoli, L [2]; Hamalainen, RH [1]; Suomalainen, A [1,8,9] [1] Univ Helsinki, Res Programs Unit, Mol Neurol, FI-00290 Helsinki, Finland [2] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy [3] Univ Senese, Univ Hosp Azienda Osped, Child Neuropsychiatry Unit, I-53100 Siena, Italy [4] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mitochondrial Disorders, NL-6500 GA Nijmegen, Netherlands [5] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy [6] Univ Hosp, AOUS, Clin Pathol Lab Unit, I-53100 Siena, Italy [7] Univ Senese, Univ Hosp Azienda Osped, Neonatal Intens Care Unit, I-53100 Siena, Italy [8] Univ Helsinki, Cent Hosp, Dept Neurol, FIN-00290 Helsinki, Finland [9] Univ Helsinki, Ctr Neurosci, FIN-00290 Helsinki, Finland",

year = "2015",

doi = "10.1038/ncomms7494",

language = "English",

volume = "6",

pages = "6494",

journal = "Nature Communications",

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Ahlqvist, KJ, Leoncini, S, Pecorelli, A, Wortmann, S, Ahola, S, Forsström, S, Guerranti, R, De Felice, C, Smeitink, J, Ciccoli, L, Hämäläinen, RH & Suomalainen, A 2015, 'MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.', Nature Communications, vol. 6, pp. 6494. https://doi.org/10.1038/ncomms7494

TY - JOUR

T1 - MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.

AU - Ahlqvist, K J

AU - Leoncini, S

AU - Pecorelli, A

AU - Wortmann, Saskia

AU - Ahola, S

AU - Forsström, S

AU - Guerranti, R

AU - De Felice, C

AU - Smeitink, J

AU - Ciccoli, L

AU - Hämäläinen, R H

AU - Suomalainen, A

N1 - Ahlqvist, KJ [1]; Leoncini, S [2,3]; Pecorelli, A [2,3]; Wortmann, SB [4]; Ahola, S [1]; Forsstrom, S [1]; Guerranti, R [5,6]; De Felice, C [7]; Smeitink, J ; Ciccoli, L [2]; Hamalainen, RH [1]; Suomalainen, A [1,8,9] [1] Univ Helsinki, Res Programs Unit, Mol Neurol, FI-00290 Helsinki, Finland [2] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy [3] Univ Senese, Univ Hosp Azienda Osped, Child Neuropsychiatry Unit, I-53100 Siena, Italy [4] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mitochondrial Disorders, NL-6500 GA Nijmegen, Netherlands [5] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy [6] Univ Hosp, AOUS, Clin Pathol Lab Unit, I-53100 Siena, Italy [7] Univ Senese, Univ Hosp Azienda Osped, Neonatal Intens Care Unit, I-53100 Siena, Italy [8] Univ Helsinki, Cent Hosp, Dept Neurol, FIN-00290 Helsinki, Finland [9] Univ Helsinki, Ctr Neurosci, FIN-00290 Helsinki, Finland

PY - 2015

Y1 - 2015

KW - OXIDATIVE STRESS

KW - RETICULOCYTE MATURATION

KW - MUTATOR MICE

KW - IN-VIVO

KW - INDEPENDENT MECHANISMS

KW - ORGANELLE DEGRADATION

KW - DNA DELETION

KW - CLEARANCE

KW - ANEMIA

KW - CELLS

U2 - 10.1038/ncomms7494

DO - 10.1038/ncomms7494

M3 - Original Article

C2 - 25751021

SN - 2041-1723

VL - 6

SP - 6494

JO - Nature Communications

JF - Nature Communications

ER -