Meta-Analysis of Pain Management in Epidermolysis Bullosa

Christian Puttinger; Gretha Hecke; Sophie Strobl; Petra Hitthaler-Waigner; Tobias Welponer; Georg Zimmermann; Martin Laimer; Gudrun Salamon

doi:10.1093/bjd/ljag104

Meta-Analysis of Pain Management in Epidermolysis Bullosa

Christian Puttinger^* (First author)
, Gretha Hecke
, Sophie Strobl
, Petra Hitthaler-Waigner
, Tobias Welponer (Co-author)
, Georg Zimmermann (Co-author)
, Martin Laimer (Last author)
, Gudrun Salamon

^*Corresponding author for this work

Sigmund Freud University Vienna
Department of Sociology and Human Geography, Paris Lodron University of Salzburg, Salzburg, Austria

Research output: Contribution to journal › Letter to the editor › peer-review

Abstract

Pain is one of the most burdensome symptoms for patients with epidermolysis bullosa (EB) and, owing to disease heterogeneity, pain management requires an individualized approach. This meta-analysis identified nine studies: of those, four topical and one systemic study reported a significant improvement in pain scores. The variety of different tools used for measuring pain underscores the importance of fostering harmonization in patient-reported outcome measurement tools, especially in pain.

Original language	English
Pages (from-to)	162-164
Number of pages	3
Journal	BRITISH JOURNAL OF DERMATOLOGY
Volume	195
Issue number	1
Early online date	23 Mar 2026
DOIs	https://doi.org/10.1093/bjd/ljag104
Publication status	Published - Jul 2026

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10.1093/bjd/ljag104

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title = "Meta-Analysis of Pain Management in Epidermolysis Bullosa",

abstract = "Pain is one of the most burdensome symptoms for patients with epidermolysis bullosa (EB) and, owing to disease heterogeneity, pain management requires an individualized approach. This meta-analysis identified nine studies: of those, four topical and one systemic study reported a significant improvement in pain scores. The variety of different tools used for measuring pain underscores the importance of fostering harmonization in patient-reported outcome measurement tools, especially in pain.",

author = "Christian Puttinger and Gretha Hecke and Sophie Strobl and Petra Hitthaler-Waigner and Tobias Welponer and Georg Zimmermann and Martin Laimer and Gudrun Salamon",

note = "Puttinger, Hecke, Welponer, Zimmermann, Laimer: Department of Dermatology and Allergology and EB House Austria, University Hospital of the Paracelsus Medical University Salzburg, Austria; Zimmermann: Research Programme Biomedical Data Science, Paracelsus Medical University, Salzburg,14 Austriia; Laimer and Salamon: Shared last authorship contributed equally",

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language = "English",

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T1 - Meta-Analysis of Pain Management in Epidermolysis Bullosa

AU - Puttinger, Christian

AU - Hecke, Gretha

AU - Strobl, Sophie

AU - Hitthaler-Waigner, Petra

AU - Welponer, Tobias

AU - Zimmermann, Georg

AU - Laimer, Martin

AU - Salamon, Gudrun

N1 - Puttinger, Hecke, Welponer, Zimmermann, Laimer: Department of Dermatology and Allergology and EB House Austria, University Hospital of the Paracelsus Medical University Salzburg, Austria; Zimmermann: Research Programme Biomedical Data Science, Paracelsus Medical University, Salzburg,14 Austriia; Laimer and Salamon: Shared last authorship contributed equally

PY - 2026/7

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N2 - Pain is one of the most burdensome symptoms for patients with epidermolysis bullosa (EB) and, owing to disease heterogeneity, pain management requires an individualized approach. This meta-analysis identified nine studies: of those, four topical and one systemic study reported a significant improvement in pain scores. The variety of different tools used for measuring pain underscores the importance of fostering harmonization in patient-reported outcome measurement tools, especially in pain.

AB - Pain is one of the most burdensome symptoms for patients with epidermolysis bullosa (EB) and, owing to disease heterogeneity, pain management requires an individualized approach. This meta-analysis identified nine studies: of those, four topical and one systemic study reported a significant improvement in pain scores. The variety of different tools used for measuring pain underscores the importance of fostering harmonization in patient-reported outcome measurement tools, especially in pain.

U2 - 10.1093/bjd/ljag104

DO - 10.1093/bjd/ljag104

M3 - Letter to the editor

C2 - 41866785

SN - 0007-0963

VL - 195

SP - 162

EP - 164

JO - BRITISH JOURNAL OF DERMATOLOGY

JF - BRITISH JOURNAL OF DERMATOLOGY

IS - 1

ER -

Meta-Analysis of Pain Management in Epidermolysis Bullosa

Abstract

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