Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.

Stephan Schreml; Robert J Meier; Michael Kirschbaum; Su Chii Kong; Sebastian Gehmert; Oliver Felthaus; Sarah Küchler; Justin R Sharpe; Kerstin Wöltje; Katharina T Weiß; Markus Albert; Uwe Seidl; Josef Schröder; Christian Morsczeck; Lukas Prantl; Claus Duschl; Stine F Pedersen; Martin Gosau; Mark Berneburg; Otto S Wolfbeis; Michael Landthaler; Philipp Babilas

doi:10.7150/thno.9052

Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.

Stephan Schreml, Robert J Meier, Michael Kirschbaum, Su Chii Kong, Sebastian Gehmert, Oliver Felthaus, Sarah Küchler, Justin R Sharpe, Kerstin Wöltje, Katharina T Weiß, Markus Albert, Uwe Seidl, Josef Schröder, Christian Morsczeck, Lukas Prantl, Claus Duschl, Stine F Pedersen, Martin Gosau (Co-author), Mark Berneburg, Otto S WolfbeisMichael Landthaler, Philipp Babilas

Research output: Contribution to journal › Original Article › peer-review

103 Citations (Web of Science)

Original language	English
Pages (from-to)	721-735
Journal	Theranostics
Volume	4
Issue number	7
DOIs	https://doi.org/10.7150/thno.9052
Publication status	Published - 2014

Keywords

PROTEIN-COUPLED RECEPTORS
HUMAN SKIN WOUNDS
IN-VIVO
KERATINOCYTE MIGRATION
HYDROGEN-PEROXIDE
CELL-MIGRATION
OXYGEN
GROWTH
MODEL
MECHANISMS

Access to Document

10.7150/thno.9052

Cite this

Schreml, S., Meier, R. J., Kirschbaum, M., Kong, S. C., Gehmert, S., Felthaus, O., Küchler, S., Sharpe, J. R., Wöltje, K., Weiß, K. T., Albert, M., Seidl, U., Schröder, J., Morsczeck, C., Prantl, L., Duschl, C., Pedersen, S. F., Gosau, M., Berneburg, M., ... Babilas, P. (2014). Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair. Theranostics, 4(7), 721-735. https://doi.org/10.7150/thno.9052

@article{acb3a79265d8475cb55105886ee494b4,

title = "Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.",

keywords = "PROTEIN-COUPLED RECEPTORS, HUMAN SKIN WOUNDS, IN-VIVO, KERATINOCYTE MIGRATION, HYDROGEN-PEROXIDE, CELL-MIGRATION, OXYGEN, GROWTH, MODEL, MECHANISMS",

author = "Stephan Schreml and Meier, \{Robert J\} and Michael Kirschbaum and Kong, \{Su Chii\} and Sebastian Gehmert and Oliver Felthaus and Sarah K{\"u}chler and Sharpe, \{Justin R\} and Kerstin W{\"o}ltje and Wei{\ss}, \{Katharina T\} and Markus Albert and Uwe Seidl and Josef Schr{\"o}der and Christian Morsczeck and Lukas Prantl and Claus Duschl and Pedersen, \{Stine F\} and Martin Gosau and Mark Berneburg and Wolfbeis, \{Otto S\} and Michael Landthaler and Philipp Babilas",

note = "Department of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Universit{\"a}tsstra{\ss}e 31, 93053 Regensburg, Germany; Fraunhofer Institute for Biomedical Engineering, Branch Potsdam, Am M{\"u}hlenberg 13, 14476 Potsdam, Germany; Department of Biology, University of Copenhagen, 13 Universitetsparken, DK-2100 Copenhagen, Denmark; Center of Plastic Surgery, Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Department of Maxillofacial Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Department of Pharmacy, Freie Universit{\"a}t Berlin, K{\"o}nigin-Luise-Str. 2-4, 14195 Berlin, Germany; Blond McIndoe Research Foundation, Queen Victoria Hospital, Holtye Road, East Grinstead RH19 3DZ, England, UK; Center for Electron Microscopy at the Institute of Pathology, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany",

year = "2014",

doi = "10.7150/thno.9052",

language = "English",

volume = "4",

pages = "721--735",

journal = "Theranostics",

issn = "1838-7640",

publisher = "Ivyspring Int Publ",

number = "7",

}

Schreml, S, Meier, RJ, Kirschbaum, M, Kong, SC, Gehmert, S, Felthaus, O, Küchler, S, Sharpe, JR, Wöltje, K, Weiß, KT, Albert, M, Seidl, U, Schröder, J, Morsczeck, C, Prantl, L, Duschl, C, Pedersen, SF, Gosau, M, Berneburg, M, Wolfbeis, OS, Landthaler, M & Babilas, P 2014, 'Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.', Theranostics, vol. 4, no. 7, pp. 721-735. https://doi.org/10.7150/thno.9052

TY - JOUR

T1 - Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.

AU - Schreml, Stephan

AU - Meier, Robert J

AU - Kirschbaum, Michael

AU - Kong, Su Chii

AU - Gehmert, Sebastian

AU - Felthaus, Oliver

AU - Küchler, Sarah

AU - Sharpe, Justin R

AU - Wöltje, Kerstin

AU - Weiß, Katharina T

AU - Albert, Markus

AU - Seidl, Uwe

AU - Schröder, Josef

AU - Morsczeck, Christian

AU - Prantl, Lukas

AU - Duschl, Claus

AU - Pedersen, Stine F

AU - Gosau, Martin

AU - Berneburg, Mark

AU - Wolfbeis, Otto S

AU - Landthaler, Michael

AU - Babilas, Philipp

N1 - Department of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany; Fraunhofer Institute for Biomedical Engineering, Branch Potsdam, Am Mühlenberg 13, 14476 Potsdam, Germany; Department of Biology, University of Copenhagen, 13 Universitetsparken, DK-2100 Copenhagen, Denmark; Center of Plastic Surgery, Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Department of Maxillofacial Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Department of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2-4, 14195 Berlin, Germany; Blond McIndoe Research Foundation, Queen Victoria Hospital, Holtye Road, East Grinstead RH19 3DZ, England, UK; Center for Electron Microscopy at the Institute of Pathology, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany

PY - 2014

Y1 - 2014

KW - PROTEIN-COUPLED RECEPTORS

KW - HUMAN SKIN WOUNDS

KW - IN-VIVO

KW - KERATINOCYTE MIGRATION

KW - HYDROGEN-PEROXIDE

KW - CELL-MIGRATION

KW - OXYGEN

KW - GROWTH

KW - MODEL

KW - MECHANISMS

U2 - 10.7150/thno.9052

DO - 10.7150/thno.9052

M3 - Original Article

C2 - 24883122

SN - 1838-7640

VL - 4

SP - 721

EP - 735

JO - Theranostics

JF - Theranostics

IS - 7

ER -