Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Stephen L Pinkosky; John W Scott; Eric M Desjardins; Brennan K Smith; Emily A Day; Rebecca J Ford; Christopher G Langendorf; Naomi X Y Ling; Tracy L Nero; Kim Loh; Sandra Galic; Ashfaqul Hoque; William Smiles; Kevin R W Ngoei; Michael W Parker; Yan Yan; Karsten Melcher; Bruce E Kemp; Jonathan S Oakhill; Gregory R Steinberg

doi:10.1038/s42255-020-0245-2

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi X Y Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William Smiles, Kevin R W Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Research Program of Receptor Biochemistry and Tumor Metabolism

Research output: Contribution to journal › Original Article › peer-review

84 Citations (Web of Science)

Original language	English
Pages (from-to)	873-881
Journal	NATURE METABOLISM
Volume	2
Issue number	9
DOIs	https://doi.org/10.1038/s42255-020-0245-2
Publication status	Published - 2020

Keywords

ACTIVATED PROTEIN-KINASE
STRUCTURAL BASIS
ACID OXIDATION
MALONYL-COA
RAT-LIVER
PHOSPHORYLATION
CARBOXYLASE
INHIBITION
BINDING
IDENTIFICATION

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10.1038/s42255-020-0245-2

Cite this

Pinkosky, S. L., Scott, J. W., Desjardins, E. M., Smith, B. K., Day, E. A., Ford, R. J., Langendorf, C. G., Ling, N. X. Y., Nero, T. L., Loh, K., Galic, S., Hoque, A., Smiles, W., Ngoei, K. R. W., Parker, M. W., Yan, Y., Melcher, K., Kemp, B. E., Oakhill, J. S., & Steinberg, G. R. (2020). Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms. NATURE METABOLISM, 2(9), 873-881. https://doi.org/10.1038/s42255-020-0245-2

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title = "Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.",

keywords = "ACTIVATED PROTEIN-KINASE, STRUCTURAL BASIS, ACID OXIDATION, MALONYL-COA, RAT-LIVER, PHOSPHORYLATION, CARBOXYLASE, INHIBITION, BINDING, IDENTIFICATION",

author = "Pinkosky, {Stephen L} and Scott, {John W} and Desjardins, {Eric M} and Smith, {Brennan K} and Day, {Emily A} and Ford, {Rebecca J} and Langendorf, {Christopher G} and Ling, {Naomi X Y} and Nero, {Tracy L} and Kim Loh and Sandra Galic and Ashfaqul Hoque and William Smiles and Ngoei, {Kevin R W} and Parker, {Michael W} and Yan Yan and Karsten Melcher and Kemp, {Bruce E} and Oakhill, {Jonathan S} and Steinberg, {Gregory R}",

year = "2020",

doi = "10.1038/s42255-020-0245-2",

language = "English",

volume = "2",

pages = "873--881",

journal = "NATURE METABOLISM",

issn = "2522-5812",

number = "9",

}

Pinkosky, SL, Scott, JW, Desjardins, EM, Smith, BK, Day, EA, Ford, RJ, Langendorf, CG, Ling, NXY, Nero, TL, Loh, K, Galic, S, Hoque, A, Smiles, W, Ngoei, KRW, Parker, MW, Yan, Y, Melcher, K, Kemp, BE, Oakhill, JS & Steinberg, GR 2020, 'Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.', NATURE METABOLISM, vol. 2, no. 9, pp. 873-881. https://doi.org/10.1038/s42255-020-0245-2

TY - JOUR

T1 - Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

AU - Pinkosky, Stephen L

AU - Scott, John W

AU - Desjardins, Eric M

AU - Smith, Brennan K

AU - Day, Emily A

AU - Ford, Rebecca J

AU - Langendorf, Christopher G

AU - Ling, Naomi X Y

AU - Nero, Tracy L

AU - Loh, Kim

AU - Galic, Sandra

AU - Hoque, Ashfaqul

AU - Smiles, William

AU - Ngoei, Kevin R W

AU - Parker, Michael W

AU - Yan, Yan

AU - Melcher, Karsten

AU - Kemp, Bruce E

AU - Oakhill, Jonathan S

AU - Steinberg, Gregory R

PY - 2020

Y1 - 2020

KW - ACTIVATED PROTEIN-KINASE

KW - STRUCTURAL BASIS

KW - ACID OXIDATION

KW - MALONYL-COA

KW - RAT-LIVER

KW - PHOSPHORYLATION

KW - CARBOXYLASE

KW - INHIBITION

KW - BINDING

KW - IDENTIFICATION

U2 - 10.1038/s42255-020-0245-2

DO - 10.1038/s42255-020-0245-2

M3 - Original Article

C2 - 32719536

SN - 2522-5812

VL - 2

SP - 873

EP - 881

JO - NATURE METABOLISM

JF - NATURE METABOLISM

IS - 9

ER -