Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Julia Marschallinger; Tal Iram; Macy Zardeneta; Song E Lee; Benoit Lehallier; Michael S Haney; John V Pluvinage; Vidhu Mathur; Oliver Hahn; David W Morgens; Justin Kim; Julia Tevini; Thomas Felder; Heimo Wolinski; Carolyn R Bertozzi; Michael C Bassik; Ludwig Aigner; Tony Wyss-Coray

doi:10.1038/s41593-019-0566-1

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Julia Marschallinger (First author)
, Tal Iram
, Macy Zardeneta
, Song E Lee
, Benoit Lehallier
, Michael S Haney
, John V Pluvinage
, Vidhu Mathur
, Oliver Hahn
, David W Morgens
, Justin Kim
, Julia Tevini (Co-author)
, Thomas Felder (Co-author)
, Heimo Wolinski
, Carolyn R Bertozzi
, Michael C Bassik
, Ludwig Aigner (Co-author)
, Tony Wyss-Coray

Research output: Contribution to journal › Correction › peer-review

1008 Citations (Web of Science)

Original language	English
Pages (from-to)	194-208
Journal	NATURE NEUROSCIENCE
Volume	23
Issue number	2
DOIs	https://doi.org/10.1038/s41593-019-0566-1
Publication status	Published - 2020

Keywords

FOAM CELLS
MOUSE
EXPRESSION
NEURODEGENERATION
PHAGOCYTOSIS
TRAFFICKING
ACTIVATION
SCLEROSIS
TARGET

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10.1038/s41593-019-0566-1

Shotgun lipidomics for the identification of plasma ceramide profiles of obese-healthy and obese-NAFLD patients
Felder, T. (PI) & Aigner, E. (CoPI)
17/10/17 → 17/10/19
Project: Research

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Marschallinger, J., Iram, T., Zardeneta, M., Lee, S. E., Lehallier, B., Haney, M. S., Pluvinage, J. V., Mathur, V., Hahn, O., Morgens, D. W., Kim, J., Tevini, J., Felder, T., Wolinski, H., Bertozzi, C. R., Bassik, M. C., Aigner, L., & Wyss-Coray, T. (2020). Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. NATURE NEUROSCIENCE, 23(2), 194-208. https://doi.org/10.1038/s41593-019-0566-1

@article{585ccd612e404a86ae0730921803fae1,

title = "Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.",

keywords = "FOAM CELLS, MOUSE, EXPRESSION, NEURODEGENERATION, PHAGOCYTOSIS, TRAFFICKING, ACTIVATION, SCLEROSIS, TARGET",

author = "Julia Marschallinger and Tal Iram and Macy Zardeneta and Lee, \{Song E\} and Benoit Lehallier and Haney, \{Michael S\} and Pluvinage, \{John V\} and Vidhu Mathur and Oliver Hahn and Morgens, \{David W\} and Justin Kim and Julia Tevini and Thomas Felder and Heimo Wolinski and Bertozzi, \{Carolyn R\} and Bassik, \{Michael C\} and Ludwig Aigner and Tony Wyss-Coray",

note = "Marschallinger, Bassik, Aigner: Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; Tevini, Felder: Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria",

year = "2020",

doi = "10.1038/s41593-019-0566-1",

language = "English",

volume = "23",

pages = "194--208",

journal = "NATURE NEUROSCIENCE",

issn = "1097-6256",

publisher = "NATURE PORTFOLIO",

number = "2",

}

Marschallinger, J, Iram, T, Zardeneta, M, Lee, SE, Lehallier, B, Haney, MS, Pluvinage, JV, Mathur, V, Hahn, O, Morgens, DW, Kim, J, Tevini, J , Felder, T, Wolinski, H, Bertozzi, CR, Bassik, MC, Aigner, L & Wyss-Coray, T 2020, 'Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.', NATURE NEUROSCIENCE, vol. 23, no. 2, pp. 194-208. https://doi.org/10.1038/s41593-019-0566-1

TY - JOUR

T1 - Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

AU - Marschallinger, Julia

AU - Iram, Tal

AU - Zardeneta, Macy

AU - Lee, Song E

AU - Lehallier, Benoit

AU - Haney, Michael S

AU - Pluvinage, John V

AU - Mathur, Vidhu

AU - Hahn, Oliver

AU - Morgens, David W

AU - Kim, Justin

AU - Tevini, Julia

AU - Felder, Thomas

AU - Wolinski, Heimo

AU - Bertozzi, Carolyn R

AU - Bassik, Michael C

AU - Aigner, Ludwig

AU - Wyss-Coray, Tony

N1 - Marschallinger, Bassik, Aigner: Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; Tevini, Felder: Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria

PY - 2020

Y1 - 2020

KW - FOAM CELLS

KW - MOUSE

KW - EXPRESSION

KW - NEURODEGENERATION

KW - PHAGOCYTOSIS

KW - TRAFFICKING

KW - ACTIVATION

KW - SCLEROSIS

KW - TARGET

U2 - 10.1038/s41593-019-0566-1

DO - 10.1038/s41593-019-0566-1

M3 - Correction

C2 - 31959936

SN - 1097-6256

VL - 23

SP - 194

EP - 208

JO - NATURE NEUROSCIENCE

JF - NATURE NEUROSCIENCE

IS - 2

ER -

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Keywords

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Projects

Shotgun lipidomics for the identification of plasma ceramide profiles of obese-healthy and obese-NAFLD patients

Cite this