Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.

Bernhard Scharinger; Barbara Messner; Adrian Türkcan; Daniela Brigitte Schuster; Anna Vuorinen; Florian Pitterl; Katharina Heinz; Kathrin Arnhard; Günther Laufer; Michael Grimm; Hermann Stuppner; Herbert Oberacher; Philipp Eller; Andreas Ritsch; David Bernhard

doi:10.1016/j.yjmcc.2016.08.003

Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.

Bernhard Scharinger (First author), Barbara Messner, Adrian Türkcan, Daniela Brigitte Schuster (Co-author), Anna Vuorinen, Florian Pitterl, Katharina Heinz, Kathrin Arnhard, Günther Laufer, Michael Grimm, Hermann Stuppner, Herbert Oberacher, Philipp Eller, Andreas Ritsch, David Bernhard

Research output: Contribution to journal › Original Article › peer-review

17 Citations (Web of Science)

Original language	English
Pages (from-to)	35-46
Journal	JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume	99
DOIs	https://doi.org/10.1016/j.yjmcc.2016.08.003
Publication status	Published - 2016

Keywords

CORONARY-HEART-DISEASE
ESTER TRANSFER PROTEIN
HMG-COA REDUCTASE
CONFORMER GENERATION
STATIN THERAPY
DATA-BANK
ATHEROSCLEROSIS
PHARMACOPHORES
METABOLISM
MECHANISM

Access to Document

10.1016/j.yjmcc.2016.08.003

Cite this

Scharinger, B., Messner, B., Türkcan, A., Schuster, D. B., Vuorinen, A., Pitterl, F., Heinz, K., Arnhard, K., Laufer, G., Grimm, M., Stuppner, H., Oberacher, H., Eller, P., Ritsch, A., & Bernhard, D. (2016). Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY , 99, 35-46. https://doi.org/10.1016/j.yjmcc.2016.08.003

Scharinger, Bernhard ; Messner, Barbara ; Türkcan, Adrian et al. / Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 2016 ; Vol. 99. pp. 35-46.

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title = "Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.",

keywords = "CORONARY-HEART-DISEASE, ESTER TRANSFER PROTEIN, HMG-COA REDUCTASE, CONFORMER GENERATION, STATIN THERAPY, DATA-BANK, ATHEROSCLEROSIS, PHARMACOPHORES, METABOLISM, MECHANISM",

author = "Bernhard Scharinger and Barbara Messner and Adrian T{\"u}rkcan and Schuster, {Daniela Brigitte} and Anna Vuorinen and Florian Pitterl and Katharina Heinz and Kathrin Arnhard and G{\"u}nther Laufer and Michael Grimm and Hermann Stuppner and Herbert Oberacher and Philipp Eller and Andreas Ritsch and David Bernhard",

year = "2016",

doi = "10.1016/j.yjmcc.2016.08.003",

language = "English",

volume = "99",

pages = "35--46",

journal = "JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY ",

issn = "0022-2828",

publisher = "Elsevier ",

}

Scharinger, B, Messner, B, Türkcan, A, Schuster, DB, Vuorinen, A, Pitterl, F, Heinz, K, Arnhard, K, Laufer, G, Grimm, M, Stuppner, H, Oberacher, H, Eller, P, Ritsch, A & Bernhard, D 2016, 'Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.', JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY , vol. 99, pp. 35-46. https://doi.org/10.1016/j.yjmcc.2016.08.003

Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. / Scharinger, Bernhard (First author); Messner, Barbara; Türkcan, Adrian et al.
In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY , Vol. 99, 2016, p. 35-46.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.

AU - Scharinger, Bernhard

AU - Messner, Barbara

AU - Türkcan, Adrian

AU - Schuster, Daniela Brigitte

AU - Vuorinen, Anna

AU - Pitterl, Florian

AU - Heinz, Katharina

AU - Arnhard, Kathrin

AU - Laufer, Günther

AU - Grimm, Michael

AU - Stuppner, Hermann

AU - Oberacher, Herbert

AU - Eller, Philipp

AU - Ritsch, Andreas

AU - Bernhard, David

PY - 2016

Y1 - 2016

KW - CORONARY-HEART-DISEASE

KW - ESTER TRANSFER PROTEIN

KW - HMG-COA REDUCTASE

KW - CONFORMER GENERATION

KW - STATIN THERAPY

KW - DATA-BANK

KW - ATHEROSCLEROSIS

KW - PHARMACOPHORES

KW - METABOLISM

KW - MECHANISM

U2 - 10.1016/j.yjmcc.2016.08.003

DO - 10.1016/j.yjmcc.2016.08.003

M3 - Original Article

C2 - 27497529

SN - 0022-2828

VL - 99

SP - 35

EP - 46

JO - JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

JF - JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ER -

Scharinger B, Messner B, Türkcan A, Schuster DB, Vuorinen A, Pitterl F et al. Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . 2016;99:35-46. doi: 10.1016/j.yjmcc.2016.08.003