JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

Susanne Adam; Nils Simon; Ulrike Steffen; Fabian T Andes; Carina Scholtysek; Dorothea I H Müller; Daniela Weidner; Darja Andreev; Arnd Kleyer; Stephan Culemann; Madelaine Hahn; Georg Schett; Gerhard Krönke; Silke Frey; Axel Hueber

doi:10.1126/scitranslmed.aay4447

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

Susanne Adam, Nils Simon, Ulrike Steffen, Fabian T Andes, Carina Scholtysek, Dorothea I H Müller, Daniela Weidner, Darja Andreev, Arnd Kleyer, Stephan Culemann, Madelaine Hahn, Georg Schett, Gerhard Krönke, Silke Frey, Axel Hueber (Last author)

Research output: Contribution to journal › Original Article › peer-review

102 Citations (Web of Science)

Original language	English
Journal	SCIENCE TRANSLATIONAL MEDICINE
Volume	12
Issue number	530
DOIs	https://doi.org/10.1126/scitranslmed.aay4447
Publication status	Published - 2020

Keywords

STROMAL CELLS
STEM-CELLS
ACTIVATION
DIFFERENTIATION
TOFACITINIB
PATHWAY
METHOTREXATE
CYTOKINES
TURNOVER
CATENIN

Access to Document

10.1126/scitranslmed.aay4447

Cite this

Adam, S., Simon, N., Steffen, U., Andes, F. T., Scholtysek, C., Müller, D. I. H., Weidner, D., Andreev, D., Kleyer, A., Culemann, S., Hahn, M., Schett, G., Krönke, G., Frey, S., & Hueber, A. (2020). JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function. SCIENCE TRANSLATIONAL MEDICINE, 12(530). https://doi.org/10.1126/scitranslmed.aay4447

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title = "JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.",

keywords = "STROMAL CELLS, STEM-CELLS, ACTIVATION, DIFFERENTIATION, TOFACITINIB, PATHWAY, METHOTREXATE, CYTOKINES, TURNOVER, CATENIN",

author = "Susanne Adam and Nils Simon and Ulrike Steffen and Andes, {Fabian T} and Carina Scholtysek and M{\"u}ller, {Dorothea I H} and Daniela Weidner and Darja Andreev and Arnd Kleyer and Stephan Culemann and Madelaine Hahn and Georg Schett and Gerhard Kr{\"o}nke and Silke Frey and Axel Hueber",

year = "2020",

doi = "10.1126/scitranslmed.aay4447",

language = "English",

volume = "12",

journal = "SCIENCE TRANSLATIONAL MEDICINE",

issn = "1946-6234",

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Adam, S, Simon, N, Steffen, U, Andes, FT, Scholtysek, C, Müller, DIH, Weidner, D, Andreev, D, Kleyer, A, Culemann, S, Hahn, M, Schett, G, Krönke, G, Frey, S & Hueber, A 2020, 'JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.', SCIENCE TRANSLATIONAL MEDICINE, vol. 12, no. 530. https://doi.org/10.1126/scitranslmed.aay4447

TY - JOUR

T1 - JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

AU - Adam, Susanne

AU - Simon, Nils

AU - Steffen, Ulrike

AU - Andes, Fabian T

AU - Scholtysek, Carina

AU - Müller, Dorothea I H

AU - Weidner, Daniela

AU - Andreev, Darja

AU - Kleyer, Arnd

AU - Culemann, Stephan

AU - Hahn, Madelaine

AU - Schett, Georg

AU - Krönke, Gerhard

AU - Frey, Silke

AU - Hueber, Axel

PY - 2020

Y1 - 2020

KW - STROMAL CELLS

KW - STEM-CELLS

KW - ACTIVATION

KW - DIFFERENTIATION

KW - TOFACITINIB

KW - PATHWAY

KW - METHOTREXATE

KW - CYTOKINES

KW - TURNOVER

KW - CATENIN

U2 - 10.1126/scitranslmed.aay4447

DO - 10.1126/scitranslmed.aay4447

M3 - Original Article

C2 - 32051226

SN - 1946-6234

VL - 12

JO - SCIENCE TRANSLATIONAL MEDICINE

JF - SCIENCE TRANSLATIONAL MEDICINE

IS - 530

ER -