Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

Daniel I Chasman; Christian Fuchsberger; Cristian Pattaro; Alexander Teumer; Carsten A Böger; Karlhans Endlich; Matthias Olden; Ming-Huei Chen; Adrienne Tin; Daniel Taliun; Man Li; Xiaoyi Gao; Mathias Gorski; Qiong Yang; Claudia Hundertmark; Meredith C Foster; Conall M O"Seaghdha; Nicole Glazer; Aaron Isaacs; Ching-Ti Liu; Albert V Smith; Jeffrey R O"Connell; Maksim Struchalin; Toshiko Tanaka; Guo Li; Andrew D Johnson; Hinco J Gierman; Mary F Feitosa; Shih-Jen Hwang; Elizabeth J Atkinson; Kurt Lohman; Marilyn C Cornelis; Asa Johansson; Anke Tönjes; Abbas Dehghan; Jean-Charles Lambert; Elizabeth G Holliday; Rossella Sorice; Zoltan Kutalik; Terho Lehtimäki; Tõnu Esko; Harshal Deshmukh; Sheila Ulivi; Audrey Y Chu; Federico Murgia; Stella Trompet; Medea Imboden; Stefan Coassin; Giorgio Pistis; Tamara B Harris; Lenore J Launer; Thor Aspelund; Gudny Eiriksdottir; Braxton D Mitchell; Eric Boerwinkle; Helena Schmidt; Margherita Cavalieri; Madhumathi Rao; Frank Hu; Ayse Demirkan; Ben A Oostra; Mariza de Andrade; Stephen T Turner; Jingzhong Ding; Jeanette S Andrews; Barry I Freedman; Franco Giulianini; Wolfgang Koenig; Thomas Illig; Christa Meisinger; Christian Gieger; Lina Zgaga; Tatijana Zemunik; Mladen Boban; Cosetta Minelli; Heather E Wheeler; Wilmar Igl; Ghazal Zaboli; Sarah H Wild; Alan F Wright; Harry Campbell; David Ellinghaus; Ute Nöthlings; Gunnar Jacobs; Reiner Biffar; Florian Ernst; Georg Homuth; Heyo K Kroemer; Matthias Nauck; Sylvia Stracke; Uwe Völker; Henry Völzke; Peter Kovacs; Michael Stumvoll; Reedik Mägi; Albert Hofman; Andre G Uitterlinden; Fernando Rivadeneira; Yurii S Aulchenko; Ozren Polasek; Nick Hastie; Veronique Vitart; Catherine Helmer; Jie Jin Wang; Bénédicte Stengel; Daniela Ruggiero; Sven Bergmann; Mika Kähönen; Jorma Viikari; Tiit Nikopensius; Michael Province; Shamika Ketkar; Helen Colhoun; Alex Doney; Antonietta Robino; Bernhard K Krämer; Laura Portas; Ian Ford; Brendan M Buckley; Martin Adam; Gian-Andri Thun; Bernhard Paulweber; Margot Haun; Cinzia Sala; Paul Mitchell; Marina Ciullo; Stuart K Kim; Peter Vollenweider; Olli Raitakari; Andres Metspalu; Colin Palmer; Paolo Gasparini; Mario Pirastu; J Wouter Jukema; Nicole M Probst-Hensch; Florian Kronenberg; Daniela Toniolo; Vilmundur Gudnason; Alan R Shuldiner; Josef Coresh; Reinhold Schmidt; Luigi Ferrucci; David S Siscovick; Cornelia M van Duijn; Ingrid B Borecki; Sharon L R Kardia; Yongmei Liu; Gary C Curhan; Igor Rudan; Ulf Gyllensten; James F Wilson; Andre Franke; Peter P Pramstaller; Rainer Rettig; Inga Prokopenko; Jacqueline Witteman; Caroline Hayward; Paul M Ridker; Afshin Parsa; Murielle Bochud; Iris M Heid; W H Linda Kao; Caroline S Fox; Anna Köttgen

doi:10.1093/hmg/dds369

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

Daniel I Chasman, Christian Fuchsberger, Cristian Pattaro, Alexander Teumer, Carsten A Böger, Karlhans Endlich, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, Claudia Hundertmark, Meredith C Foster, Conall M O"Seaghdha, Nicole Glazer, Aaron Isaacs, Ching-Ti LiuAlbert V Smith, Jeffrey R O"Connell, Maksim Struchalin, Toshiko Tanaka, Guo Li, Andrew D Johnson, Hinco J Gierman, Mary F Feitosa, Shih-Jen Hwang, Elizabeth J Atkinson, Kurt Lohman, Marilyn C Cornelis, Asa Johansson, Anke Tönjes, Abbas Dehghan, Jean-Charles Lambert, Elizabeth G Holliday, Rossella Sorice, Zoltan Kutalik, Terho Lehtimäki, Tõnu Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Y Chu, Federico Murgia, Stella Trompet, Medea Imboden, Stefan Coassin, Giorgio Pistis, Tamara B Harris, Lenore J Launer, Thor Aspelund, Gudny Eiriksdottir, Braxton D Mitchell, Eric Boerwinkle, Helena Schmidt, Margherita Cavalieri, Madhumathi Rao, Frank Hu, Ayse Demirkan, Ben A Oostra, Mariza de Andrade, Stephen T Turner, Jingzhong Ding, Jeanette S Andrews, Barry I Freedman, Franco Giulianini, Wolfgang Koenig, Thomas Illig, Christa Meisinger, Christian Gieger, Lina Zgaga, Tatijana Zemunik, Mladen Boban, Cosetta Minelli, Heather E Wheeler, Wilmar Igl, Ghazal Zaboli, Sarah H Wild, Alan F Wright, Harry Campbell, David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Reiner Biffar, Florian Ernst, Georg Homuth, Heyo K Kroemer, Matthias Nauck, Sylvia Stracke, Uwe Völker, Henry Völzke, Peter Kovacs, Michael Stumvoll, Reedik Mägi, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Yurii S Aulchenko, Ozren Polasek, Nick Hastie, Veronique Vitart, Catherine Helmer, Jie Jin Wang, Bénédicte Stengel, Daniela Ruggiero, Sven Bergmann, Mika Kähönen, Jorma Viikari, Tiit Nikopensius, Michael Province, Shamika Ketkar, Helen Colhoun, Alex Doney, Antonietta Robino, Bernhard K Krämer, Laura Portas, Ian Ford, Brendan M Buckley, Martin Adam, Gian-Andri Thun, Bernhard Paulweber (Co-author), Margot Haun, Cinzia Sala, Paul Mitchell, Marina Ciullo, Stuart K Kim, Peter Vollenweider, Olli Raitakari, Andres Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J Wouter Jukema, Nicole M Probst-Hensch, Florian Kronenberg, Daniela Toniolo, Vilmundur Gudnason, Alan R Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, David S Siscovick, Cornelia M van Duijn, Ingrid B Borecki, Sharon L R Kardia, Yongmei Liu, Gary C Curhan, Igor Rudan, Ulf Gyllensten, James F Wilson, Andre Franke, Peter P Pramstaller, Rainer Rettig, Inga Prokopenko, Jacqueline Witteman, Caroline Hayward, Paul M Ridker, Afshin Parsa, Murielle Bochud, Iris M Heid, W H Linda Kao, Caroline S Fox, Anna Köttgen

Department of Internal Medicine I- Division of Gastroenterology, Hepatology, Nephrology, Metabolism and Diabetologylog

Research output: Contribution to journal › Original Article › peer-review

53 Citations (Web of Science)

Original language	English
Pages (from-to)	5329-5343
Journal	HUMAN MOLECULAR GENETICS
Volume	21
Issue number	24
DOIs	https://doi.org/10.1093/hmg/dds369
Publication status	Published - 2012

Keywords

GLOMERULAR-FILTRATION-RATE
COMMUNITY-BASED POPULATION
SERUM CREATININE
RENAL-FUNCTION
R PACKAGE
DISEASE
EXPRESSION
LOCI
TRAITS
SNPS

Access to Document

10.1093/hmg/dds369

Cite this

Chasman, D. I., Fuchsberger, C., Pattaro, C., Teumer, A., Böger, C. A., Endlich, K., Olden, M., Chen, M.-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O"Seaghdha, C. M., Glazer, N., Isaacs, A., ... Köttgen, A. (2012). Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. HUMAN MOLECULAR GENETICS , 21(24), 5329-5343. https://doi.org/10.1093/hmg/dds369

Chasman, Daniel I ; Fuchsberger, Christian ; Pattaro, Cristian et al. / Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. In: HUMAN MOLECULAR GENETICS 2012 ; Vol. 21, No. 24. pp. 5329-5343.

@article{f28b065c331e44ae82d741188572ba4b,

title = "Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.",

keywords = "GLOMERULAR-FILTRATION-RATE, COMMUNITY-BASED POPULATION, SERUM CREATININE, RENAL-FUNCTION, R PACKAGE, DISEASE, EXPRESSION, LOCI, TRAITS, SNPS",

author = "Chasman, \{Daniel I\} and Christian Fuchsberger and Cristian Pattaro and Alexander Teumer and B{\"o}ger, \{Carsten A\} and Karlhans Endlich and Matthias Olden and Ming-Huei Chen and Adrienne Tin and Daniel Taliun and Man Li and Xiaoyi Gao and Mathias Gorski and Qiong Yang and Claudia Hundertmark and Foster, \{Meredith C\} and O{"}Seaghdha, \{Conall M\} and Nicole Glazer and Aaron Isaacs and Ching-Ti Liu and Smith, \{Albert V\} and O{"}Connell, \{Jeffrey R\} and Maksim Struchalin and Toshiko Tanaka and Guo Li and Johnson, \{Andrew D\} and Gierman, \{Hinco J\} and Feitosa, \{Mary F\} and Shih-Jen Hwang and Atkinson, \{Elizabeth J\} and Kurt Lohman and Cornelis, \{Marilyn C\} and Asa Johansson and Anke T{\"o}njes and Abbas Dehghan and Jean-Charles Lambert and Holliday, \{Elizabeth G\} and Rossella Sorice and Zoltan Kutalik and Terho Lehtim{\"a}ki and T{\~o}nu Esko and Harshal Deshmukh and Sheila Ulivi and Chu, \{Audrey Y\} and Federico Murgia and Stella Trompet and Medea Imboden and Stefan Coassin and Giorgio Pistis and Harris, \{Tamara B\} and Launer, \{Lenore J\} and Thor Aspelund and Gudny Eiriksdottir and Mitchell, \{Braxton D\} and Eric Boerwinkle and Helena Schmidt and Margherita Cavalieri and Madhumathi Rao and Frank Hu and Ayse Demirkan and Oostra, \{Ben A\} and \{de Andrade\}, Mariza and Turner, \{Stephen T\} and Jingzhong Ding and Andrews, \{Jeanette S\} and Freedman, \{Barry I\} and Franco Giulianini and Wolfgang Koenig and Thomas Illig and Christa Meisinger and Christian Gieger and Lina Zgaga and Tatijana Zemunik and Mladen Boban and Cosetta Minelli and Wheeler, \{Heather E\} and Wilmar Igl and Ghazal Zaboli and Wild, \{Sarah H\} and Wright, \{Alan F\} and Harry Campbell and David Ellinghaus and Ute N{\"o}thlings and Gunnar Jacobs and Reiner Biffar and Florian Ernst and Georg Homuth and Kroemer, \{Heyo K\} and Matthias Nauck and Sylvia Stracke and Uwe V{\"o}lker and Henry V{\"o}lzke and Peter Kovacs and Michael Stumvoll and Reedik M{\"a}gi and Albert Hofman and Uitterlinden, \{Andre G\} and Fernando Rivadeneira and Aulchenko, \{Yurii S\} and Ozren Polasek and Nick Hastie and Veronique Vitart and Catherine Helmer and Wang, \{Jie Jin\} and B{\'e}n{\'e}dicte Stengel and Daniela Ruggiero and Sven Bergmann and Mika K{\"a}h{\"o}nen and Jorma Viikari and Tiit Nikopensius and Michael Province and Shamika Ketkar and Helen Colhoun and Alex Doney and Antonietta Robino and Kr{\"a}mer, \{Bernhard K\} and Laura Portas and Ian Ford and Buckley, \{Brendan M\} and Martin Adam and Gian-Andri Thun and Bernhard Paulweber and Margot Haun and Cinzia Sala and Paul Mitchell and Marina Ciullo and Kim, \{Stuart K\} and Peter Vollenweider and Olli Raitakari and Andres Metspalu and Colin Palmer and Paolo Gasparini and Mario Pirastu and Jukema, \{J Wouter\} and Probst-Hensch, \{Nicole M\} and Florian Kronenberg and Daniela Toniolo and Vilmundur Gudnason and Shuldiner, \{Alan R\} and Josef Coresh and Reinhold Schmidt and Luigi Ferrucci and Siscovick, \{David S\} and \{van Duijn\}, \{Cornelia M\} and Borecki, \{Ingrid B\} and Kardia, \{Sharon L R\} and Yongmei Liu and Curhan, \{Gary C\} and Igor Rudan and Ulf Gyllensten and Wilson, \{James F\} and Andre Franke and Pramstaller, \{Peter P\} and Rainer Rettig and Inga Prokopenko and Jacqueline Witteman and Caroline Hayward and Ridker, \{Paul M\} and Afshin Parsa and Murielle Bochud and Heid, \{Iris M\} and Kao, \{W H Linda\} and Fox, \{Caroline S\} and Anna K{\"o}ttgen",

note = "First Department of Internal Medicine, Paracelsus Medical University, Muellner Hauptstra{\ss}e 48, Salzburg 5020, Austria",

year = "2012",

doi = "10.1093/hmg/dds369",

language = "English",

volume = "21",

pages = "5329--5343",

journal = "HUMAN MOLECULAR GENETICS ",

issn = "0964-6906",

number = "24",

}

Chasman, DI, Fuchsberger, C, Pattaro, C, Teumer, A, Böger, CA, Endlich, K, Olden, M, Chen, M-H, Tin, A, Taliun, D, Li, M, Gao, X, Gorski, M, Yang, Q, Hundertmark, C, Foster, MC, O"Seaghdha, CM, Glazer, N, Isaacs, A, Liu, C-T, Smith, AV, O"Connell, JR, Struchalin, M, Tanaka, T, Li, G, Johnson, AD, Gierman, HJ, Feitosa, MF, Hwang, S-J, Atkinson, EJ, Lohman, K, Cornelis, MC, Johansson, A, Tönjes, A, Dehghan, A, Lambert, J-C, Holliday, EG, Sorice, R, Kutalik, Z, Lehtimäki, T, Esko, T, Deshmukh, H, Ulivi, S, Chu, AY, Murgia, F, Trompet, S, Imboden, M, Coassin, S, Pistis, G, Harris, TB, Launer, LJ, Aspelund, T, Eiriksdottir, G, Mitchell, BD, Boerwinkle, E, Schmidt, H, Cavalieri, M, Rao, M, Hu, F, Demirkan, A, Oostra, BA, de Andrade, M, Turner, ST, Ding, J, Andrews, JS, Freedman, BI, Giulianini, F, Koenig, W, Illig, T, Meisinger, C, Gieger, C, Zgaga, L, Zemunik, T, Boban, M, Minelli, C, Wheeler, HE, Igl, W, Zaboli, G, Wild, SH, Wright, AF, Campbell, H, Ellinghaus, D, Nöthlings, U, Jacobs, G, Biffar, R, Ernst, F, Homuth, G, Kroemer, HK, Nauck, M, Stracke, S, Völker, U, Völzke, H, Kovacs, P, Stumvoll, M, Mägi, R, Hofman, A, Uitterlinden, AG, Rivadeneira, F, Aulchenko, YS, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, JJ, Stengel, B, Ruggiero, D, Bergmann, S, Kähönen, M, Viikari, J, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Doney, A, Robino, A, Krämer, BK, Portas, L, Ford, I, Buckley, BM, Adam, M, Thun, G-A, Paulweber, B, Haun, M, Sala, C, Mitchell, P, Ciullo, M, Kim, SK, Vollenweider, P, Raitakari, O, Metspalu, A, Palmer, C, Gasparini, P, Pirastu, M, Jukema, JW, Probst-Hensch, NM, Kronenberg, F, Toniolo, D, Gudnason, V, Shuldiner, AR, Coresh, J, Schmidt, R, Ferrucci, L, Siscovick, DS, van Duijn, CM, Borecki, IB, Kardia, SLR, Liu, Y, Curhan, GC, Rudan, I, Gyllensten, U, Wilson, JF, Franke, A, Pramstaller, PP, Rettig, R, Prokopenko, I, Witteman, J, Hayward, C, Ridker, PM, Parsa, A, Bochud, M, Heid, IM, Kao, WHL, Fox, CS & Köttgen, A 2012, 'Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.', HUMAN MOLECULAR GENETICS , vol. 21, no. 24, pp. 5329-5343. https://doi.org/10.1093/hmg/dds369

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. / Chasman, Daniel I; Fuchsberger, Christian; Pattaro, Cristian et al.
In: HUMAN MOLECULAR GENETICS , Vol. 21, No. 24, 2012, p. 5329-5343.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

AU - Chasman, Daniel I

AU - Fuchsberger, Christian

AU - Pattaro, Cristian

AU - Teumer, Alexander

AU - Böger, Carsten A

AU - Endlich, Karlhans

AU - Olden, Matthias

AU - Chen, Ming-Huei

AU - Tin, Adrienne

AU - Taliun, Daniel

AU - Li, Man

AU - Gao, Xiaoyi

AU - Gorski, Mathias

AU - Yang, Qiong

AU - Hundertmark, Claudia

AU - Foster, Meredith C

AU - O"Seaghdha, Conall M

AU - Glazer, Nicole

AU - Isaacs, Aaron

AU - Liu, Ching-Ti

AU - Smith, Albert V

AU - O"Connell, Jeffrey R

AU - Struchalin, Maksim

AU - Tanaka, Toshiko

AU - Li, Guo

AU - Johnson, Andrew D

AU - Gierman, Hinco J

AU - Feitosa, Mary F

AU - Hwang, Shih-Jen

AU - Atkinson, Elizabeth J

AU - Lohman, Kurt

AU - Cornelis, Marilyn C

AU - Johansson, Asa

AU - Tönjes, Anke

AU - Dehghan, Abbas

AU - Lambert, Jean-Charles

AU - Holliday, Elizabeth G

AU - Sorice, Rossella

AU - Kutalik, Zoltan

AU - Lehtimäki, Terho

AU - Esko, Tõnu

AU - Deshmukh, Harshal

AU - Ulivi, Sheila

AU - Chu, Audrey Y

AU - Murgia, Federico

AU - Trompet, Stella

AU - Imboden, Medea

AU - Coassin, Stefan

AU - Pistis, Giorgio

AU - Harris, Tamara B

AU - Launer, Lenore J

AU - Aspelund, Thor

AU - Eiriksdottir, Gudny

AU - Mitchell, Braxton D

AU - Boerwinkle, Eric

AU - Schmidt, Helena

AU - Cavalieri, Margherita

AU - Rao, Madhumathi

AU - Hu, Frank

AU - Demirkan, Ayse

AU - Oostra, Ben A

AU - de Andrade, Mariza

AU - Turner, Stephen T

AU - Ding, Jingzhong

AU - Andrews, Jeanette S

AU - Freedman, Barry I

AU - Giulianini, Franco

AU - Koenig, Wolfgang

AU - Illig, Thomas

AU - Meisinger, Christa

AU - Gieger, Christian

AU - Zgaga, Lina

AU - Zemunik, Tatijana

AU - Boban, Mladen

AU - Minelli, Cosetta

AU - Wheeler, Heather E

AU - Igl, Wilmar

AU - Zaboli, Ghazal

AU - Wild, Sarah H

AU - Wright, Alan F

AU - Campbell, Harry

AU - Ellinghaus, David

AU - Nöthlings, Ute

AU - Jacobs, Gunnar

AU - Biffar, Reiner

AU - Ernst, Florian

AU - Homuth, Georg

AU - Kroemer, Heyo K

AU - Nauck, Matthias

AU - Stracke, Sylvia

AU - Völker, Uwe

AU - Völzke, Henry

AU - Kovacs, Peter

AU - Stumvoll, Michael

AU - Mägi, Reedik

AU - Hofman, Albert

AU - Uitterlinden, Andre G

AU - Rivadeneira, Fernando

AU - Aulchenko, Yurii S

AU - Polasek, Ozren

AU - Hastie, Nick

AU - Vitart, Veronique

AU - Helmer, Catherine

AU - Wang, Jie Jin

AU - Stengel, Bénédicte

AU - Ruggiero, Daniela

AU - Bergmann, Sven

AU - Kähönen, Mika

AU - Viikari, Jorma

AU - Nikopensius, Tiit

AU - Province, Michael

AU - Ketkar, Shamika

AU - Colhoun, Helen

AU - Doney, Alex

AU - Robino, Antonietta

AU - Krämer, Bernhard K

AU - Portas, Laura

AU - Ford, Ian

AU - Buckley, Brendan M

AU - Adam, Martin

AU - Thun, Gian-Andri

AU - Paulweber, Bernhard

AU - Haun, Margot

AU - Sala, Cinzia

AU - Mitchell, Paul

AU - Ciullo, Marina

AU - Kim, Stuart K

AU - Vollenweider, Peter

AU - Raitakari, Olli

AU - Metspalu, Andres

AU - Palmer, Colin

AU - Gasparini, Paolo

AU - Pirastu, Mario

AU - Jukema, J Wouter

AU - Probst-Hensch, Nicole M

AU - Kronenberg, Florian

AU - Toniolo, Daniela

AU - Gudnason, Vilmundur

AU - Shuldiner, Alan R

AU - Coresh, Josef

AU - Schmidt, Reinhold

AU - Ferrucci, Luigi

AU - Siscovick, David S

AU - van Duijn, Cornelia M

AU - Borecki, Ingrid B

AU - Kardia, Sharon L R

AU - Liu, Yongmei

AU - Curhan, Gary C

AU - Rudan, Igor

AU - Gyllensten, Ulf

AU - Wilson, James F

AU - Franke, Andre

AU - Pramstaller, Peter P

AU - Rettig, Rainer

AU - Prokopenko, Inga

AU - Witteman, Jacqueline

AU - Hayward, Caroline

AU - Ridker, Paul M

AU - Parsa, Afshin

AU - Bochud, Murielle

AU - Heid, Iris M

AU - Kao, W H Linda

AU - Fox, Caroline S

AU - Köttgen, Anna

N1 - First Department of Internal Medicine, Paracelsus Medical University, Muellner Hauptstraße 48, Salzburg 5020, Austria

PY - 2012

Y1 - 2012

KW - GLOMERULAR-FILTRATION-RATE

KW - COMMUNITY-BASED POPULATION

KW - SERUM CREATININE

KW - RENAL-FUNCTION

KW - R PACKAGE

KW - DISEASE

KW - EXPRESSION

KW - LOCI

KW - TRAITS

KW - SNPS

U2 - 10.1093/hmg/dds369

DO - 10.1093/hmg/dds369

M3 - Original Article

C2 - 22962313

SN - 0964-6906

VL - 21

SP - 5329

EP - 5343

JO - HUMAN MOLECULAR GENETICS

JF - HUMAN MOLECULAR GENETICS

IS - 24

ER -

Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K et al. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. HUMAN MOLECULAR GENETICS . 2012;21(24):5329-5343. doi: 10.1093/hmg/dds369