Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.

Andrea Trost; Karolina Motloch; Andreas Koller; Daniela Bruckner; Christian Runge; Falk Schroedl; Barbara Bogner; Alexandra Kaser-Eichberger; Clemens Strohmaier; Anja-Maria Ladek; Julia Preishuber-Pfluegl; Susanne Brunner; Ludwig Aigner; Herbert Reitsamer

doi:10.1016/j.exer.2021.108806

Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.

Andrea Trost^* (First author), Karolina Motloch, Andreas Koller (Co-author), Daniela Bruckner (Co-author), Christian Runge (Co-author), Falk Schroedl (Co-author), Barbara Bogner (Co-author), Alexandra Kaser-Eichberger (Co-author), Clemens Strohmaier (Co-author), Anja-Maria Ladek, Julia Preishuber-Pfluegl (Co-author), Susanne Brunner (Co-author), Ludwig Aigner (Co-author), Herbert Reitsamer (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article (Journal) › peer-review

8 Citations (Web of Science)

Original language	English
Pages (from-to)	108806
Journal	EXPERIMENTAL EYE RESEARCH
Volume	213
DOIs	https://doi.org/10.1016/j.exer.2021.108806
Publication status	Published - 2021

Keywords

FOCAL CEREBRAL-ISCHEMIA
NECROSIS-FACTOR-ALPHA
GANGLION-CELL DEATH
DBA/2J MOUSE MODEL
OPTIC-NERVE
SPINAL-CORD
RECEPTOR-1 ANTAGONIST
INTRAOCULAR-PRESSURE
NEURONAL INJURY
IN-VIVO

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10.1016/j.exer.2021.108806

Cite this

Trost, A., Motloch, K., Koller, A., Bruckner, D., Runge, C., Schroedl, F., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Ladek, A.-M., Preishuber-Pfluegl, J., Brunner, S., Aigner, L., & Reitsamer, H. (2021). Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension. EXPERIMENTAL EYE RESEARCH , 213, 108806. https://doi.org/10.1016/j.exer.2021.108806

Trost, Andrea ; Motloch, Karolina ; Koller, Andreas et al. / Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension. In: EXPERIMENTAL EYE RESEARCH 2021 ; Vol. 213. pp. 108806.

@article{8701147ed6e3468c9c3af1bf01fa006a,

title = "Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.",

keywords = "FOCAL CEREBRAL-ISCHEMIA, NECROSIS-FACTOR-ALPHA, GANGLION-CELL DEATH, DBA/2J MOUSE MODEL, OPTIC-NERVE, SPINAL-CORD, RECEPTOR-1 ANTAGONIST, INTRAOCULAR-PRESSURE, NEURONAL INJURY, IN-VIVO",

author = "Andrea Trost and Karolina Motloch and Andreas Koller and Daniela Bruckner and Christian Runge and Falk Schroedl and Barbara Bogner and Alexandra Kaser-Eichberger and Clemens Strohmaier and Anja-Maria Ladek and Julia Preishuber-Pfluegl and Susanne Brunner and Ludwig Aigner and Herbert Reitsamer",

note = "all but Aigner: University Clinic of Ophthalmology and Optometry, Research Program for Ophthalmology and Glaucoma Research, Paracelsus Medical University/SALK, 5020, Salzburg, Austria; Scjr{\"o}dl; Kaser-Eichberger: Center for Anatomy and Cell Biology, Institute of Anatomy and Cell Biology - Salzburg, Paracelsus Medical University, Salzburg, Austria; Aigner: Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Aigner; REitsamer: Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University Salzburg, Austria",

year = "2021",

doi = "10.1016/j.exer.2021.108806",

language = "English",

volume = "213",

pages = "108806",

journal = "EXPERIMENTAL EYE RESEARCH ",

issn = "0014-4835",

}

Trost, A, Motloch, K, Koller, A , Bruckner, D , Runge, C , Schroedl, F , Bogner, B, Kaser-Eichberger, A, Strohmaier, C, Ladek, A-M, Preishuber-Pfluegl, J , Brunner, S , Aigner, L & Reitsamer, H 2021, 'Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.', EXPERIMENTAL EYE RESEARCH , vol. 213, pp. 108806. https://doi.org/10.1016/j.exer.2021.108806

Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension. / Trost, Andrea (First author); Motloch, Karolina; Koller, Andreas (Co-author) et al.
In: EXPERIMENTAL EYE RESEARCH , Vol. 213, 2021, p. 108806.

Research output: Contribution to journal › Original Article (Journal) › peer-review

TY - JOUR

T1 - Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.

AU - Trost, Andrea

AU - Motloch, Karolina

AU - Koller, Andreas

AU - Bruckner, Daniela

AU - Runge, Christian

AU - Schroedl, Falk

AU - Bogner, Barbara

AU - Kaser-Eichberger, Alexandra

AU - Strohmaier, Clemens

AU - Ladek, Anja-Maria

AU - Preishuber-Pfluegl, Julia

AU - Brunner, Susanne

AU - Aigner, Ludwig

AU - Reitsamer, Herbert

N1 - all but Aigner: University Clinic of Ophthalmology and Optometry, Research Program for Ophthalmology and Glaucoma Research, Paracelsus Medical University/SALK, 5020, Salzburg, Austria; Scjrödl; Kaser-Eichberger: Center for Anatomy and Cell Biology, Institute of Anatomy and Cell Biology - Salzburg, Paracelsus Medical University, Salzburg, Austria; Aigner: Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Aigner; REitsamer: Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University Salzburg, Austria

PY - 2021

Y1 - 2021

KW - FOCAL CEREBRAL-ISCHEMIA

KW - NECROSIS-FACTOR-ALPHA

KW - GANGLION-CELL DEATH

KW - DBA/2J MOUSE MODEL

KW - OPTIC-NERVE

KW - SPINAL-CORD

KW - RECEPTOR-1 ANTAGONIST

KW - INTRAOCULAR-PRESSURE

KW - NEURONAL INJURY

KW - IN-VIVO

U2 - 10.1016/j.exer.2021.108806

DO - 10.1016/j.exer.2021.108806

M3 - Original Article (Journal)

C2 - 34715090

SN - 0014-4835

VL - 213

SP - 108806

JO - EXPERIMENTAL EYE RESEARCH

JF - EXPERIMENTAL EYE RESEARCH

ER -

Trost A, Motloch K, Koller A , Bruckner D , Runge C , Schroedl F et al. Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension. EXPERIMENTAL EYE RESEARCH . 2021;213:108806. doi: 10.1016/j.exer.2021.108806