Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

J Bolik; F Krause; M Stevanovic; M Gandrass; I Thomsen; SS Schacht; E Rieser; M Mueller; N Schumacher; J Fritsch; R Wichert; E Galun; Jürgen Bergmann; C Roeder; C Schafmayer; JH Egberts; C Becker-Pauly; P Saftig; R Lucius; W Schneider-Brachert; R Barikbin; D Adam; M Voss; Wolfgang Hitzl; A Krueger; B Strilic; I Sagi; H Walczak; S Rose-John; D Schmidt-Arras

doi:10.1084/jem.20201039

Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

J Bolik
, F Krause
, M Stevanovic
, M Gandrass
, I Thomsen
, SS Schacht
, E Rieser
, M Mueller
, N Schumacher
, J Fritsch
, R Wichert
, E Galun
, Jürgen Bergmann
, C Roeder
, C Schafmayer
, JH Egberts
, C Becker-Pauly
, P Saftig
, R Lucius
, W Schneider-Brachert

R Barikbin, D Adam, M Voss, Wolfgang Hitzl, A Krueger, B Strilic, I Sagi, H Walczak, S Rose-John, D Schmidt-Arras

Research output: Contribution to journal › Original Article › peer-review

51 Citations (Web of Science)

Original language	English
Pages (from-to)	e20201039
Journal	Journal of experimental medicine
Volume	219
Issue number	1
DOIs	https://doi.org/10.1084/jem.20201039
Publication status	Published - 2021

Keywords

TUMOR-NECROSIS-FACTOR
FACTOR RECEPTOR
MYELOID CELLS
INFLAMMATION
EXTRAVASATION
DISINTEGRIN
ACTIVATION
LETHALITY
DISEASE

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10.1084/jem.20201039

Cite this

Bolik, J., Krause, F., Stevanovic, M., Gandrass, M., Thomsen, I., Schacht, SS., Rieser, E., Mueller, M., Schumacher, N., Fritsch, J., Wichert, R., Galun, E., Bergmann, J., Roeder, C., Schafmayer, C., Egberts, JH., Becker-Pauly, C., Saftig, P., Lucius, R., ... Schmidt-Arras, D. (2021). Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. Journal of experimental medicine, 219(1), e20201039. https://doi.org/10.1084/jem.20201039

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Bolik, J, Krause, F, Stevanovic, M, Gandrass, M, Thomsen, I, Schacht, SS, Rieser, E, Mueller, M, Schumacher, N, Fritsch, J, Wichert, R, Galun, E, Bergmann, J, Roeder, C, Schafmayer, C, Egberts, JH, Becker-Pauly, C, Saftig, P, Lucius, R, Schneider-Brachert, W, Barikbin, R, Adam, D, Voss, M, Hitzl, W, Krueger, A, Strilic, B, Sagi, I, Walczak, H, Rose-John, S & Schmidt-Arras, D 2021, 'Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis', Journal of experimental medicine, vol. 219, no. 1, pp. e20201039. https://doi.org/10.1084/jem.20201039

TY - JOUR

T1 - Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

AU - Bolik, J

AU - Krause, F

AU - Stevanovic, M

AU - Gandrass, M

AU - Thomsen, I

AU - Schacht, SS

AU - Rieser, E

AU - Mueller, M

AU - Schumacher, N

AU - Fritsch, J

AU - Wichert, R

AU - Galun, E

AU - Bergmann, Jürgen

AU - Roeder, C

AU - Schafmayer, C

AU - Egberts, JH

AU - Becker-Pauly, C

AU - Saftig, P

AU - Lucius, R

AU - Schneider-Brachert, W

AU - Barikbin, R

AU - Adam, D

AU - Voss, M

AU - Hitzl, Wolfgang

AU - Krueger, A

AU - Strilic, B

AU - Sagi, I

AU - Walczak, H

AU - Rose-John, S

AU - Schmidt-Arras, D

PY - 2021

Y1 - 2021

KW - TUMOR-NECROSIS-FACTOR

KW - FACTOR RECEPTOR

KW - MYELOID CELLS

KW - INFLAMMATION

KW - EXTRAVASATION

KW - DISINTEGRIN

KW - ACTIVATION

KW - LETHALITY

KW - DISEASE

U2 - 10.1084/jem.20201039

DO - 10.1084/jem.20201039

M3 - Original Article

C2 - 34919140

SN - 0022-1007

VL - 219

SP - e20201039

JO - Journal of experimental medicine

JF - Journal of experimental medicine

IS - 1

ER -