TY - JOUR
T1 - Incidence and predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock
AU - Dettling, Angela
AU - Kellner, Caroline
AU - Sundermeyer, Jonas
AU - Beer, Benedikt N.
AU - Besch, Lisa
AU - Bertoldi, Letizia Fausta
AU - Blankenberg, Stefan
AU - Dauw, Jeroen
AU - Eckner, Dennis
AU - Eitel, Ingo
AU - Graf, Tobias
AU - Horn, Patrick
AU - Jozwiak-Nozdrzykowska, Joanna
AU - Kirchhof, Paulus
AU - Kluge, Stefan
AU - Krais, Jannis
AU - von Lewinski, Dirk
AU - Linke, Axel
AU - Luedike, Peter
AU - Luesebrink, Enzo
AU - Nordbeck, Peter
AU - Pappalardo, Federico
AU - Pauschinger, Matthias
AU - Proudfoot, Alastair
AU - Rassaf, Tienush
AU - Reichenspurner, Hermann
AU - Sag, Can Martin
AU - Scherer, Clemens
AU - Schulze, P. Christian
AU - Schwinger, Robert H. G.
AU - Skurk, Carsten
AU - Sramko, Marek
AU - Tavazzi, Guido
AU - Thiele, Holger
AU - Morici, Nuccia
AU - Winzer, Ephraim B.
AU - Westermann, Dirk
AU - Schrage, Benedikt
AU - Mangner, Norman
N1 - Ecker, Pauschinger: Department of Cardiology, Paracelsus Medical University Nürnberg, Nürnberg, Germany
PY - 2025/1/17
Y1 - 2025/1/17
N2 - Aims This study aimed to investigate incidence and predictors of weaning failure and in-hospital death after successful weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS). Methods and results Overall, 685 patients with CS treated with VA-ECMO from 23 tertiary care centres in 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.6 [interquartile range 4.1-12.7] mmol/L). The cause of CS was acute myocardial infarction in 438 (63.9%) patients, and 431 (62.9%) patients presented with cardiac arrest. A total of 410 patients (59.9%) were successfully weaned from VA-ECMO, whereas in 275 patients (40.1%) weaning failed (i.e. patients died on or within 48 h after VA-ECMO support). Of the successfully weaned patients, 150 (36.6%) died before hospital discharge. On multivariable logistic regression, predictors for both patient groups varied: age (per 10 years, odds ratio [OR] 1.49, 95% confidence interval [CI] 1.25-1.76; p < 0.001) and cardiac arrest before VA-ECMO implantation (OR 1.64, 95% CI 1.01-2.64; p = 0.04) were associated with weaning failure, whereas lactate clearance within 24 h after VA-ECMO initiation was associated with successful weaning (OR 0.21, 95% CI 0.1-0.44; p < 0.001). In-hospital death after successful weaning was more likely with higher age (per 10 years, OR 1.56, 95% CI 1.24-1.97; p < 0.001), renal replacement therapy (OR 2.56, 95% CI 1.4-4.68; p = 0.002) and bleeding events (OR 2.93, 95% CI 1.4-6.14; p = 0.004). Conclusion Weaning from VA-ECMO fails in 40% of patients treated with VA-ECMO for CS. When successful, survival after VA-ECMO weaning mostly depends on age and the incidence of device- and shock-related complications.
AB - Aims This study aimed to investigate incidence and predictors of weaning failure and in-hospital death after successful weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS). Methods and results Overall, 685 patients with CS treated with VA-ECMO from 23 tertiary care centres in 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.6 [interquartile range 4.1-12.7] mmol/L). The cause of CS was acute myocardial infarction in 438 (63.9%) patients, and 431 (62.9%) patients presented with cardiac arrest. A total of 410 patients (59.9%) were successfully weaned from VA-ECMO, whereas in 275 patients (40.1%) weaning failed (i.e. patients died on or within 48 h after VA-ECMO support). Of the successfully weaned patients, 150 (36.6%) died before hospital discharge. On multivariable logistic regression, predictors for both patient groups varied: age (per 10 years, odds ratio [OR] 1.49, 95% confidence interval [CI] 1.25-1.76; p < 0.001) and cardiac arrest before VA-ECMO implantation (OR 1.64, 95% CI 1.01-2.64; p = 0.04) were associated with weaning failure, whereas lactate clearance within 24 h after VA-ECMO initiation was associated with successful weaning (OR 0.21, 95% CI 0.1-0.44; p < 0.001). In-hospital death after successful weaning was more likely with higher age (per 10 years, OR 1.56, 95% CI 1.24-1.97; p < 0.001), renal replacement therapy (OR 2.56, 95% CI 1.4-4.68; p = 0.002) and bleeding events (OR 2.93, 95% CI 1.4-6.14; p = 0.004). Conclusion Weaning from VA-ECMO fails in 40% of patients treated with VA-ECMO for CS. When successful, survival after VA-ECMO weaning mostly depends on age and the incidence of device- and shock-related complications.
KW - Cardiogenic shock
KW - Mechanical circulatory support
KW - Mortality
KW - Predictors
KW - Veno-arterial extracorporeal membrane oxygenation
KW - Weaning
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pmu_pure&SrcAuth=WosAPI&KeyUT=WOS:001398582300001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1002/ejhf.3583
DO - 10.1002/ejhf.3583
M3 - Original Article
C2 - 39823252
SN - 1388-9842
JO - EUROPEAN JOURNAL OF HEART FAILURE
JF - EUROPEAN JOURNAL OF HEART FAILURE
ER -