Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants

Toni Luise Meister, Nicola Frericks, Robin D. V. Kleinert, Estefania Rodriguez, Joerg Steinmann (Co-author), Daniel Todt, Richard J. P. Brown, Eike Steinmann

Research output: Contribution to journalOriginal Articlepeer-review

Abstract

Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanal, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of similar to 13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
Original languageEnglish
Article numbere0012264
Number of pages10
JournalPLOS NEGLECTED TROPICAL DISEASES
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 2024

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