TY - JOUR
T1 - Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants
AU - Meister, Toni Luise
AU - Frericks, Nicola
AU - Kleinert, Robin D. V.
AU - Rodriguez, Estefania
AU - Steinmann, Joerg
AU - Todt, Daniel
AU - Brown, Richard J. P.
AU - Steinmann, Eike
N1 - Steinmann: Institute of Clinical Hygiene, Medical Microbiology and Infectiology, General Hospital Nürnberg, Paracelsus Medical University, Nuremberg, Germany,
PY - 2024/6
Y1 - 2024/6
N2 - Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanal, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of similar to 13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
AB - Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanal, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of similar to 13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pmu_pure&SrcAuth=WosAPI&KeyUT=WOS:001255199400002&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1371/journal.pntd.0012264
DO - 10.1371/journal.pntd.0012264
M3 - Original Article
C2 - 38900788
SN - 1935-2735
VL - 18
JO - PLOS NEGLECTED TROPICAL DISEASES
JF - PLOS NEGLECTED TROPICAL DISEASES
IS - 6
M1 - e0012264
ER -