Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG.

Cindy Franklin; Peter Mohr; Leonie Bluhm; Imke Grimmelmann; Ralf Gutzmer; Friedegund Meier; Marlene Garzarolli; Michael Weichenthal; Claudia Pfoehler; Rudolf Herbst; Patrick Terheyden; Jochen Utikal; Jens Ulrich; Dirk Debus; Sebastian Haferkamp; Martin Kaatz; Andrea Forschner; Ulrike Leiter; Dorothee Nashan; Alexander Kreuter; Michael Sachse; Julia Welzel; Lucie Heinzerling; Frank Meiss; Carsten Weishaupt; Thilo Gambichler; Gerhard Weyandt; Edgar Dippel; Kerstin Schatton; Eren Celik; Maike Trommer; Iris Helfrich; Alexander Roesch; Lisa Zimmer; Elisabeth Livingstone; Dirk Schadendorf; Susanne Horn; Selma Ugurel

doi:10.1136/jitc-2022-004509

Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG.

Cindy Franklin, Peter Mohr, Leonie Bluhm, Imke Grimmelmann, Ralf Gutzmer, Friedegund Meier, Marlene Garzarolli, Michael Weichenthal, Claudia Pfoehler, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Jens Ulrich, Dirk Debus (Co-author), Sebastian Haferkamp, Martin Kaatz, Andrea Forschner, Ulrike Leiter, Dorothee Nashan, Alexander KreuterMichael Sachse, Julia Welzel, Lucie Heinzerling, Frank Meiss, Carsten Weishaupt, Thilo Gambichler, Gerhard Weyandt, Edgar Dippel, Kerstin Schatton, Eren Celik, Maike Trommer, Iris Helfrich, Alexander Roesch, Lisa Zimmer, Elisabeth Livingstone, Dirk Schadendorf, Susanne Horn, Selma Ugurel

Department of Dermatology

Research output: Contribution to journal › Original Article › peer-review

17 Citations (Web of Science)

Original language	English
Journal	JOURNAL FOR IMMUNOTHERAPY OF CANCER
Volume	10
Issue number	6
DOIs	https://doi.org/10.1136/jitc-2022-004509
Publication status	Published - 2022

Keywords

STEREOTACTIC RADIOSURGERY
CEREBRAL METASTASES
MALIGNANT-MELANOMA
RADIATION NECROSIS
CLINICAL-OUTCOMES
OPEN-LABEL
IPILIMUMAB
INHIBITION

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10.1136/jitc-2022-004509

Cite this

Franklin, C., Mohr, P., Bluhm, L., Grimmelmann, I., Gutzmer, R., Meier, F., Garzarolli, M., Weichenthal, M., Pfoehler, C., Herbst, R., Terheyden, P., Utikal, J., Ulrich, J., Debus, D., Haferkamp, S., Kaatz, M., Forschner, A., Leiter, U., Nashan, D., ... Ugurel, S. (2022). Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 10(6). https://doi.org/10.1136/jitc-2022-004509

@article{d4caad97267c4ab3b0f0829876b79288,

title = "Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG.",

keywords = "STEREOTACTIC RADIOSURGERY, CEREBRAL METASTASES, MALIGNANT-MELANOMA, RADIATION NECROSIS, CLINICAL-OUTCOMES, OPEN-LABEL, IPILIMUMAB, INHIBITION",

author = "Cindy Franklin and Peter Mohr and Leonie Bluhm and Imke Grimmelmann and Ralf Gutzmer and Friedegund Meier and Marlene Garzarolli and Michael Weichenthal and Claudia Pfoehler and Rudolf Herbst and Patrick Terheyden and Jochen Utikal and Jens Ulrich and Dirk Debus and Sebastian Haferkamp and Martin Kaatz and Andrea Forschner and Ulrike Leiter and Dorothee Nashan and Alexander Kreuter and Michael Sachse and Julia Welzel and Lucie Heinzerling and Frank Meiss and Carsten Weishaupt and Thilo Gambichler and Gerhard Weyandt and Edgar Dippel and Kerstin Schatton and Eren Celik and Maike Trommer and Iris Helfrich and Alexander Roesch and Lisa Zimmer and Elisabeth Livingstone and Dirk Schadendorf and Susanne Horn and Selma Ugurel",

note = "Debus: Department of Dermatology, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany",

year = "2022",

doi = "10.1136/jitc-2022-004509",

language = "English",

volume = "10",

journal = "JOURNAL FOR IMMUNOTHERAPY OF CANCER",

issn = "2051-1426",

number = "6",

}

Franklin, C, Mohr, P, Bluhm, L, Grimmelmann, I, Gutzmer, R, Meier, F, Garzarolli, M, Weichenthal, M, Pfoehler, C, Herbst, R, Terheyden, P, Utikal, J, Ulrich, J, Debus, D, Haferkamp, S, Kaatz, M, Forschner, A, Leiter, U, Nashan, D, Kreuter, A, Sachse, M, Welzel, J, Heinzerling, L, Meiss, F, Weishaupt, C, Gambichler, T, Weyandt, G, Dippel, E, Schatton, K, Celik, E, Trommer, M, Helfrich, I, Roesch, A, Zimmer, L, Livingstone, E, Schadendorf, D, Horn, S & Ugurel, S 2022, 'Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG.', JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 10, no. 6. https://doi.org/10.1136/jitc-2022-004509

Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG. / Franklin, Cindy; Mohr, Peter; Bluhm, Leonie et al.
In: JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 10, No. 6, 2022.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG.

AU - Franklin, Cindy

AU - Mohr, Peter

AU - Bluhm, Leonie

AU - Grimmelmann, Imke

AU - Gutzmer, Ralf

AU - Meier, Friedegund

AU - Garzarolli, Marlene

AU - Weichenthal, Michael

AU - Pfoehler, Claudia

AU - Herbst, Rudolf

AU - Terheyden, Patrick

AU - Utikal, Jochen

AU - Ulrich, Jens

AU - Debus, Dirk

AU - Haferkamp, Sebastian

AU - Kaatz, Martin

AU - Forschner, Andrea

AU - Leiter, Ulrike

AU - Nashan, Dorothee

AU - Kreuter, Alexander

AU - Sachse, Michael

AU - Welzel, Julia

AU - Heinzerling, Lucie

AU - Meiss, Frank

AU - Weishaupt, Carsten

AU - Gambichler, Thilo

AU - Weyandt, Gerhard

AU - Dippel, Edgar

AU - Schatton, Kerstin

AU - Celik, Eren

AU - Trommer, Maike

AU - Helfrich, Iris

AU - Roesch, Alexander

AU - Zimmer, Lisa

AU - Livingstone, Elisabeth

AU - Schadendorf, Dirk

AU - Horn, Susanne

AU - Ugurel, Selma

N1 - Debus: Department of Dermatology, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany

PY - 2022

Y1 - 2022

KW - STEREOTACTIC RADIOSURGERY

KW - CEREBRAL METASTASES

KW - MALIGNANT-MELANOMA

KW - RADIATION NECROSIS

KW - CLINICAL-OUTCOMES

KW - OPEN-LABEL

KW - IPILIMUMAB

KW - INHIBITION

U2 - 10.1136/jitc-2022-004509

DO - 10.1136/jitc-2022-004509

M3 - Original Article

C2 - 35688555

SN - 2051-1426

VL - 10

JO - JOURNAL FOR IMMUNOTHERAPY OF CANCER

JF - JOURNAL FOR IMMUNOTHERAPY OF CANCER

IS - 6

ER -

Franklin C, Mohr P, Bluhm L, Grimmelmann I, Gutzmer R, Meier F et al. Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG. JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(6). doi: 10.1136/jitc-2022-004509