Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.

Daniela Brigitte Schuster; Dorota Kowalik; Johannes Kirchmair; Christian Laggner; Patrick Markt; Christel Aebischer-Gumy; Fabian Ströhle; Gabriele Möller; Gerhard Wolber; Thomas Wilckens; Thierry Langer; Alex Odermatt; Jerzy Adamski

doi:10.1016/j.jsbmb.2011.01.016

Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.

Daniela Brigitte Schuster, Dorota Kowalik, Johannes Kirchmair, Christian Laggner, Patrick Markt, Christel Aebischer-Gumy, Fabian Ströhle, Gabriele Möller, Gerhard Wolber, Thomas Wilckens, Thierry Langer, Alex Odermatt, Jerzy Adamski

Research output: Contribution to journal › Original Article › peer-review

25 Citations (Web of Science)

Original language	English
Pages (from-to)	148-161
Journal	JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume	125
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jsbmb.2011.01.016
Publication status	Published - 2011

Keywords

PROSTAGLANDIN-F-SYNTHASE
NONSTEROIDAL ANTIINFLAMMATORY DRUGS
IN-SILICO PHARMACOLOGY
KETO REDUCTASE AKR1C3
11-BETA-HYDROXYSTEROID DEHYDROGENASES
20-ALPHA-HYDROXYSTEROID DEHYDROGENASE
4-HYDROXYPHENYL KETONES
BIOCHEMICAL EVALUATION
CRYSTAL-STRUCTURES
DISCOVERY

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10.1016/j.jsbmb.2011.01.016

Cite this

Schuster, D. B., Kowalik, D., Kirchmair, J., Laggner, C., Markt, P., Aebischer-Gumy, C., Ströhle, F., Möller, G., Wolber, G., Wilckens, T., Langer, T., Odermatt, A., & Adamski, J. (2011). Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY , 125(1-2), 148-161. https://doi.org/10.1016/j.jsbmb.2011.01.016

Schuster, Daniela Brigitte ; Kowalik, Dorota ; Kirchmair, Johannes et al. / Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening. In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2011 ; Vol. 125, No. 1-2. pp. 148-161.

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title = "Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.",

keywords = "PROSTAGLANDIN-F-SYNTHASE, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, IN-SILICO PHARMACOLOGY, KETO REDUCTASE AKR1C3, 11-BETA-HYDROXYSTEROID DEHYDROGENASES, 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE, 4-HYDROXYPHENYL KETONES, BIOCHEMICAL EVALUATION, CRYSTAL-STRUCTURES, DISCOVERY",

author = "Schuster, {Daniela Brigitte} and Dorota Kowalik and Johannes Kirchmair and Christian Laggner and Patrick Markt and Christel Aebischer-Gumy and Fabian Str{\"o}hle and Gabriele M{\"o}ller and Gerhard Wolber and Thomas Wilckens and Thierry Langer and Alex Odermatt and Jerzy Adamski",

year = "2011",

doi = "10.1016/j.jsbmb.2011.01.016",

language = "English",

volume = "125",

pages = "148--161",

journal = "JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY ",

issn = "0960-0760",

number = "1-2",

}

Schuster, DB, Kowalik, D, Kirchmair, J, Laggner, C, Markt, P, Aebischer-Gumy, C, Ströhle, F, Möller, G, Wolber, G, Wilckens, T, Langer, T, Odermatt, A & Adamski, J 2011, 'Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.', JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY , vol. 125, no. 1-2, pp. 148-161. https://doi.org/10.1016/j.jsbmb.2011.01.016

Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening. / Schuster, Daniela Brigitte; Kowalik, Dorota; Kirchmair, Johannes et al.
In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY , Vol. 125, No. 1-2, 2011, p. 148-161.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.

AU - Schuster, Daniela Brigitte

AU - Kowalik, Dorota

AU - Kirchmair, Johannes

AU - Laggner, Christian

AU - Markt, Patrick

AU - Aebischer-Gumy, Christel

AU - Ströhle, Fabian

AU - Möller, Gabriele

AU - Wolber, Gerhard

AU - Wilckens, Thomas

AU - Langer, Thierry

AU - Odermatt, Alex

AU - Adamski, Jerzy

PY - 2011

Y1 - 2011

KW - PROSTAGLANDIN-F-SYNTHASE

KW - NONSTEROIDAL ANTIINFLAMMATORY DRUGS

KW - IN-SILICO PHARMACOLOGY

KW - KETO REDUCTASE AKR1C3

KW - 11-BETA-HYDROXYSTEROID DEHYDROGENASES

KW - 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE

KW - 4-HYDROXYPHENYL KETONES

KW - BIOCHEMICAL EVALUATION

KW - CRYSTAL-STRUCTURES

KW - DISCOVERY

U2 - 10.1016/j.jsbmb.2011.01.016

DO - 10.1016/j.jsbmb.2011.01.016

M3 - Original Article

C2 - 21300150

SN - 0960-0760

VL - 125

SP - 148

EP - 161

JO - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

JF - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

IS - 1-2

ER -

Schuster DB, Kowalik D, Kirchmair J, Laggner C, Markt P, Aebischer-Gumy C et al. Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY . 2011;125(1-2):148-161. doi: 10.1016/j.jsbmb.2011.01.016