Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.

Simon T Schäfer; Sophia Gessner; André Scherag; Katharina Rump; Ulrich H Frey; Winfried Siffert; Astrid M Westendorf; Jörg Steinmann; Jürgen Peters; Michael Adamzik

doi:10.1371/journal.pone.0104953

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.

Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik

Institute of Clinical Microbiology, Infectious Diseases and Infection Control

Research output: Contribution to journal › Original Article › peer-review

41 Citations (Web of Science)

Original language	English
Pages (from-to)	e104953
Journal	PLOS ONE
Volume	9
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0104953
Publication status	Published - 2014

Keywords

SURVIVING SEPSIS CAMPAIGN
NEGATIVE REGULATION
ORGAN FAILURE
SCORE
GLUCOCORTICOIDS
MULTICENTER
GUIDELINES
MONOCYTES
RESPONSES
THERAPY

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10.1371/journal.pone.0104953

Cite this

Schäfer, S. T., Gessner, S., Scherag, A., Rump, K., Frey, U. H., Siffert, W., Westendorf, A. M., Steinmann, J., Peters, J., & Adamzik, M. (2014). Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. PLOS ONE, 9(8), e104953. https://doi.org/10.1371/journal.pone.0104953

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keywords = "SURVIVING SEPSIS CAMPAIGN, NEGATIVE REGULATION, ORGAN FAILURE, SCORE, GLUCOCORTICOIDS, MULTICENTER, GUIDELINES, MONOCYTES, RESPONSES, THERAPY",

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Schäfer, ST, Gessner, S, Scherag, A, Rump, K, Frey, UH, Siffert, W, Westendorf, AM, Steinmann, J, Peters, J & Adamzik, M 2014, 'Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.', PLOS ONE, vol. 9, no. 8, pp. e104953. https://doi.org/10.1371/journal.pone.0104953

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. / Schäfer, Simon T; Gessner, Sophia; Scherag, André et al.
In: PLOS ONE, Vol. 9, No. 8, 2014, p. e104953.

Research output: Contribution to journal › Original Article › peer-review

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AU - Schäfer, Simon T

AU - Gessner, Sophia

AU - Scherag, André

AU - Rump, Katharina

AU - Frey, Ulrich H

AU - Siffert, Winfried

AU - Westendorf, Astrid M

AU - Steinmann, Jörg

AU - Peters, Jürgen

AU - Adamzik, Michael

PY - 2014

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KW - SURVIVING SEPSIS CAMPAIGN

KW - NEGATIVE REGULATION

KW - ORGAN FAILURE

KW - SCORE

KW - GLUCOCORTICOIDS

KW - MULTICENTER

KW - GUIDELINES

KW - MONOCYTES

KW - RESPONSES

KW - THERAPY

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DO - 10.1371/journal.pone.0104953

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