Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.

Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik

Research output: Contribution to journalOriginal Article (Journal)peer-review

40 Citations (Web of Science)
Original languageEnglish
Pages (from-to)e104953
JournalPLOS ONE
Volume9
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • SURVIVING SEPSIS CAMPAIGN
  • NEGATIVE REGULATION
  • ORGAN FAILURE
  • SCORE
  • GLUCOCORTICOIDS
  • MULTICENTER
  • GUIDELINES
  • MONOCYTES
  • RESPONSES
  • THERAPY

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