Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.

Lilian Quero; Marina Klawitter; Anja Schmaus; Melanie Rothley; Jonathan Sleeman; André N Tiaden; Juergen Klasen; Norbert Boos; Michael O Hottiger; Karin Wuertz; Peter J Richards

doi:10.1186/ar4274

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.

Lilian Quero, Marina Klawitter, Anja Schmaus, Melanie Rothley, Jonathan Sleeman, André N Tiaden, Juergen Klasen, Norbert Boos, Michael O Hottiger, Karin Wuertz (Co-author), Peter J Richards

Research output: Contribution to journal › Original Article › peer-review

80 Citations (Web of Science)

Original language	English
Pages (from-to)	R94
Journal	ARTHRITIS RESEARCH AND THERAPY
Volume	15
Issue number	4
DOIs	https://doi.org/10.1186/ar4274
Publication status	Published - 2013

Keywords

LOW-BACK-PAIN
NF-KAPPA-B
TNF-ALPHA
ARTICULAR CHONDROCYTES
NUCLEUS PULPOSUS
FIBRONECTIN FRAGMENTS
EXTRACELLULAR-MATRIX
DEGENERATION
EXPRESSION
OLIGOSACCHARIDES

Access to Document

10.1186/ar4274

Cite this

Quero, L., Klawitter, M., Schmaus, A., Rothley, M., Sleeman, J., Tiaden, A. N., Klasen, J., Boos, N., Hottiger, M. O., Wuertz, K., & Richards, P. J. (2013). Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. ARTHRITIS RESEARCH AND THERAPY, 15(4), R94. https://doi.org/10.1186/ar4274

@article{268c78dbbe47486799271173bce13229,

title = "Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.",

keywords = "LOW-BACK-PAIN, NF-KAPPA-B, TNF-ALPHA, ARTICULAR CHONDROCYTES, NUCLEUS PULPOSUS, FIBRONECTIN FRAGMENTS, EXTRACELLULAR-MATRIX, DEGENERATION, EXPRESSION, OLIGOSACCHARIDES",

author = "Lilian Quero and Marina Klawitter and Anja Schmaus and Melanie Rothley and Jonathan Sleeman and Tiaden, {Andr{\'e} N} and Juergen Klasen and Norbert Boos and Hottiger, {Michael O} and Karin Wuertz and Richards, {Peter J}",

note = "Wuertz-Kozak: Spine Research Group, CABMM, University of Z{\"u}rich, Winterthurerstrasse 190, Z{\"u}rich, 8057, Switzerland; AOSpine Research Network, Stettbachstrasse 6, Duebendorf, 8600, Switzerland Zurich Centre for Integrative Human Physiology (ZIHP), University of Z{\"u}rich, Winterthurerstrasse 190, Z{\"u}rich, 8057, Switzerland; Institute for Biomechanics, Swiss Federal Institute of Technology (ETH), Wolfgang-Pauli-Strasse 10, Z{\"u}rich, 8093, Switzerland",

year = "2013",

doi = "10.1186/ar4274",

language = "English",

volume = "15",

pages = "R94",

journal = "ARTHRITIS RESEARCH AND THERAPY",

issn = "1478-6354",

publisher = " BioMed Central",

number = "4",

}

Quero, L, Klawitter, M, Schmaus, A, Rothley, M, Sleeman, J, Tiaden, AN, Klasen, J, Boos, N, Hottiger, MO, Wuertz, K & Richards, PJ 2013, 'Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.', ARTHRITIS RESEARCH AND THERAPY, vol. 15, no. 4, pp. R94. https://doi.org/10.1186/ar4274

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. / Quero, Lilian; Klawitter, Marina; Schmaus, Anja et al.
In: ARTHRITIS RESEARCH AND THERAPY, Vol. 15, No. 4, 2013, p. R94.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.

AU - Quero, Lilian

AU - Klawitter, Marina

AU - Schmaus, Anja

AU - Rothley, Melanie

AU - Sleeman, Jonathan

AU - Tiaden, André N

AU - Klasen, Juergen

AU - Boos, Norbert

AU - Hottiger, Michael O

AU - Wuertz, Karin

AU - Richards, Peter J

N1 - Wuertz-Kozak: Spine Research Group, CABMM, University of Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland; AOSpine Research Network, Stettbachstrasse 6, Duebendorf, 8600, Switzerland Zurich Centre for Integrative Human Physiology (ZIHP), University of Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland; Institute for Biomechanics, Swiss Federal Institute of Technology (ETH), Wolfgang-Pauli-Strasse 10, Zürich, 8093, Switzerland

PY - 2013

Y1 - 2013

KW - LOW-BACK-PAIN

KW - NF-KAPPA-B

KW - TNF-ALPHA

KW - ARTICULAR CHONDROCYTES

KW - NUCLEUS PULPOSUS

KW - FIBRONECTIN FRAGMENTS

KW - EXTRACELLULAR-MATRIX

KW - DEGENERATION

KW - EXPRESSION

KW - OLIGOSACCHARIDES

U2 - 10.1186/ar4274

DO - 10.1186/ar4274

M3 - Original Article

C2 - 23968377

SN - 1478-6354

VL - 15

SP - R94

JO - ARTHRITIS RESEARCH AND THERAPY

JF - ARTHRITIS RESEARCH AND THERAPY

IS - 4

ER -