Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation.

Verena Krauth; Ferdinando Bruno; Simona Pace; Paul M Jordan; Veronika Temml; Maria Preziosa Romano; Haroon Khan; Daniela Brigitte Schuster; Antonietta Rossi; Rosanna Filosa; Oliver Werz

doi:10.1016/j.bcp.2022.115385

Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation.

Verena Krauth, Ferdinando Bruno, Simona Pace, Paul M Jordan, Veronika Temml (Co-author), Maria Preziosa Romano, Haroon Khan, Daniela Brigitte Schuster (Co-author), Antonietta Rossi, Rosanna Filosa, Oliver Werz

Insitute of Pharmacy

Research output: Contribution to journal › Original Article › peer-review

5 Citations (Web of Science)

Original language	English
Pages (from-to)	115385
Journal	BIOCHEMICAL PHARMACOLOGY
Volume	208
Early online date	17 Dec 2022
DOIs	https://doi.org/10.1016/j.bcp.2022.115385
Publication status	Published - Feb 2023

Keywords

ARACHIDONIC-ACID RELEASE
LEUKOTRIENE BIOSYNTHESIS
FLAVONOIDS
INTERFERENCE
DERIVATIVES
PRODUCTS
ZILEUTON
IRON
Humans
Animals
Catechols/pharmacology
Arachidonate 5-Lipoxygenase/metabolism
HEK293 Cells
Lipoxygenase Inhibitors/pharmacology
Mice
Inflammation/drug therapy

Access to Document

10.1016/j.bcp.2022.115385

Cite this

Krauth, V., Bruno, F., Pace, S., Jordan, P. M., Temml, V., Preziosa Romano, M., Khan, H., Schuster, D. B., Rossi, A., Filosa, R., & Werz, O. (2023). Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. BIOCHEMICAL PHARMACOLOGY , 208, 115385. https://doi.org/10.1016/j.bcp.2022.115385

Krauth, Verena ; Bruno, Ferdinando ; Pace, Simona et al. / Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. In: BIOCHEMICAL PHARMACOLOGY 2023 ; Vol. 208. pp. 115385.

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title = "Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation.",

keywords = "ARACHIDONIC-ACID RELEASE, LEUKOTRIENE BIOSYNTHESIS, FLAVONOIDS, INTERFERENCE, DERIVATIVES, PRODUCTS, ZILEUTON, IRON, Humans, Animals, Catechols/pharmacology, Arachidonate 5-Lipoxygenase/metabolism, HEK293 Cells, Lipoxygenase Inhibitors/pharmacology, Mice, Inflammation/drug therapy",

author = "Verena Krauth and Ferdinando Bruno and Simona Pace and Jordan, {Paul M} and Veronika Temml and {Preziosa Romano}, Maria and Haroon Khan and Schuster, {Daniela Brigitte} and Antonietta Rossi and Rosanna Filosa and Oliver Werz",

year = "2023",

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doi = "10.1016/j.bcp.2022.115385",

language = "English",

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pages = "115385",

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Krauth, V, Bruno, F, Pace, S, Jordan, PM, Temml, V, Preziosa Romano, M, Khan, H, Schuster, DB, Rossi, A, Filosa, R & Werz, O 2023, 'Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation.', BIOCHEMICAL PHARMACOLOGY , vol. 208, pp. 115385. https://doi.org/10.1016/j.bcp.2022.115385

Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. / Krauth, Verena; Bruno, Ferdinando; Pace, Simona et al.
In: BIOCHEMICAL PHARMACOLOGY , Vol. 208, 02.2023, p. 115385.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation.

AU - Krauth, Verena

AU - Bruno, Ferdinando

AU - Pace, Simona

AU - Jordan, Paul M

AU - Temml, Veronika

AU - Preziosa Romano, Maria

AU - Khan, Haroon

AU - Schuster, Daniela Brigitte

AU - Rossi, Antonietta

AU - Filosa, Rosanna

AU - Werz, Oliver

PY - 2023/2

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KW - FLAVONOIDS

KW - INTERFERENCE

KW - DERIVATIVES

KW - PRODUCTS

KW - ZILEUTON

KW - IRON

KW - Humans

KW - Animals

KW - Catechols/pharmacology

KW - Arachidonate 5-Lipoxygenase/metabolism

KW - HEK293 Cells

KW - Lipoxygenase Inhibitors/pharmacology

KW - Mice

KW - Inflammation/drug therapy

U2 - 10.1016/j.bcp.2022.115385

DO - 10.1016/j.bcp.2022.115385

M3 - Original Article

C2 - 36535528

SN - 0006-2952

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SP - 115385

JO - BIOCHEMICAL PHARMACOLOGY

JF - BIOCHEMICAL PHARMACOLOGY

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Krauth V, Bruno F, Pace S, Jordan PM, Temml V, Preziosa Romano M et al. Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. BIOCHEMICAL PHARMACOLOGY . 2023 Feb;208:115385. Epub 2022 Dec 17. doi: 10.1016/j.bcp.2022.115385