Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes.

Oliver March; Thomas Lettner; Alfred Klausegger; Michael Ablinger; Thomas Kocher; Stefan Hainzl; Patricia Peking; Nina Lackner; Neil Rajan; Josefina Piñón Hofbauer; Christina Guttmann-Gruber; Anette Bygum; Ulrich Koller; Julia Reichelt

doi:10.1016/j.jid.2019.03.1146

Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes.

Oliver March (First author), Thomas Lettner (Co-author), Alfred Klausegger (Co-author), Michael Ablinger (Co-author), Thomas Kocher (Co-author), Stefan Hainzl (Co-author), Patricia Peking (Co-author), Nina Lackner, Neil Rajan, Josefina Piñón Hofbauer (Co-author), Christina Guttmann-Gruber (Co-author), Anette Bygum, Ulrich Koller (Last author), Julia Reichelt^* (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article › peer-review

29 Citations (Web of Science)

Original language	English
Pages (from-to)	1699-1710.e6
Journal	JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume	139
Issue number	8
DOIs	https://doi.org/10.1016/j.jid.2019.03.1146
Publication status	Published - 2019

Keywords

IMMORTALIZED KERATINOCYTES
KERATIN-10
MUTATION
HYPERKERATOSIS
PHENOTYPE
REPAIR
CELLS
CRISPR/CAS9
DELETION
DATABASE

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10.1016/j.jid.2019.03.1146

Cite this

March, O., Lettner, T., Klausegger, A., Ablinger, M., Kocher, T., Hainzl, S., Peking, P., Lackner, N., Rajan, N., Hofbauer, J. P., Guttmann-Gruber, C., Bygum, A., Koller, U., & Reichelt, J. (2019). Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 139(8), 1699-1710.e6. https://doi.org/10.1016/j.jid.2019.03.1146

March, Oliver ; Lettner, Thomas ; Klausegger, Alfred et al. / Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. In: JOURNAL OF INVESTIGATIVE DERMATOLOGY 2019 ; Vol. 139, No. 8. pp. 1699-1710.e6.

@article{41460eefe36d494494e8672604eaca4c,

title = "Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes.",

keywords = "IMMORTALIZED KERATINOCYTES, KERATIN-10, MUTATION, HYPERKERATOSIS, PHENOTYPE, REPAIR, CELLS, CRISPR/CAS9, DELETION, DATABASE",

author = "Oliver March and Thomas Lettner and Alfred Klausegger and Michael Ablinger and Thomas Kocher and Stefan Hainzl and Patricia Peking and Nina Lackner and Neil Rajan and Hofbauer, {Josefina Pi{\~n}{\'o}n} and Christina Guttmann-Gruber and Anette Bygum and Ulrich Koller and Julia Reichelt",

note = "March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Hofbauer, JP; Guttmann-Gruber, C; Koller, U; Reichelt; J: EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria; Peking, P: Experimental and Clinical Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria",

year = "2019",

doi = "10.1016/j.jid.2019.03.1146",

language = "English",

volume = "139",

pages = "1699--1710.e6",

journal = "JOURNAL OF INVESTIGATIVE DERMATOLOGY ",

issn = "0022-202X",

publisher = "Elsevier ",

number = "8",

}

March, O, Lettner, T, Klausegger, A , Ablinger, M , Kocher, T , Hainzl, S, Peking, P, Lackner, N, Rajan, N, Hofbauer, JP , Guttmann-Gruber, C, Bygum, A, Koller, U & Reichelt, J 2019, 'Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes.', JOURNAL OF INVESTIGATIVE DERMATOLOGY , vol. 139, no. 8, pp. 1699-1710.e6. https://doi.org/10.1016/j.jid.2019.03.1146

Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. / March, Oliver (First author); Lettner, Thomas (Co-author); Klausegger, Alfred (Co-author) et al.
In: JOURNAL OF INVESTIGATIVE DERMATOLOGY , Vol. 139, No. 8, 2019, p. 1699-1710.e6.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes.

AU - March, Oliver

AU - Lettner, Thomas

AU - Klausegger, Alfred

AU - Ablinger, Michael

AU - Kocher, Thomas

AU - Hainzl, Stefan

AU - Peking, Patricia

AU - Lackner, Nina

AU - Rajan, Neil

AU - Hofbauer, Josefina Piñón

AU - Guttmann-Gruber, Christina

AU - Bygum, Anette

AU - Koller, Ulrich

AU - Reichelt, Julia

N1 - March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Hofbauer, JP; Guttmann-Gruber, C; Koller, U; Reichelt; J: EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria; Peking, P: Experimental and Clinical Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria

PY - 2019

Y1 - 2019

KW - IMMORTALIZED KERATINOCYTES

KW - KERATIN-10

KW - MUTATION

KW - HYPERKERATOSIS

KW - PHENOTYPE

KW - REPAIR

KW - CELLS

KW - CRISPR/CAS9

KW - DELETION

KW - DATABASE

U2 - 10.1016/j.jid.2019.03.1146

DO - 10.1016/j.jid.2019.03.1146

M3 - Original Article

C2 - 30998984

SN - 0022-202X

VL - 139

SP - 1699-1710.e6

JO - JOURNAL OF INVESTIGATIVE DERMATOLOGY

JF - JOURNAL OF INVESTIGATIVE DERMATOLOGY

IS - 8

ER -

March O, Lettner T, Klausegger A , Ablinger M , Kocher T , Hainzl S et al. Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY . 2019;139(8):1699-1710.e6. doi: 10.1016/j.jid.2019.03.1146