Exploring the Complexities of Non-Bacterial Thrombotic Endocarditis: Highlights from Literature and Case Studies

Giuseppe Santarpino* (First author), Francesca Lofrumento, Concetta Zito, Olimpia Trio, Davide Restelli, Maurizio Cusmà Piccione, Roberta Manganaro, Scipione Carerj, Francesco Cardetta, Corrado Fiore, Cesare de Gregorio

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-bacterial thrombotic endocarditis (NBTE) is a form of non-infective endocarditis characterized by the deposition of sterile fibrin and platelets on cardiac valves. Even though some studies have identified important pathophysiological features, many aspects remain poorly understood. Given its wide availability, transthoracic echocardiography is typically the initial diagnostic approach to the patient. Additionally, recent technological advancements in transesophageal echocardiography, such as three-dimensional and multiplanar reconstruction analysis, have significantly improved diagnostic accuracy over time. By presenting our case series and performing a literature review, we focused on the main pathophysiologic, diagnostic, and therapeutic aspects of this rare but potentially life-threatening disease.

Original languageEnglish
Article number4904
Number of pages15
JournalJournal of Clinical Medicine
Volume13
Issue number16
DOIs
Publication statusPublished - 20 Aug 2024

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