DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

Nathan C Sheffield; Gaelle Pierron; Johanna Klughammer; Paul Datlinger; Andreas Schönegger; Michael Schuster; Johanna Hadler; Didier Surdez; Delphine Guillemot; Eve Lapouble; Paul Freneaux; Jacqueline Champigneulle; Raymonde Bouvier; Diana Walder; Ingeborg M Ambros; Caroline Hutter; Eva Sorz; Ana T Amaral; Enrique de Álava; Katharina Schallmoser; Dirk Strunk; Beate Rinner; Bernadette Liegl-Atzwanger; Berthold Huppertz; Andreas Leithner; Gonzague de Pinieux; Philippe Terrier; Valérie Laurence; Jean Michon; Ruth Ladenstein; Wolfgang Holter; Reinhard Windhager; Uta Dirksen; Peter F Ambros; Olivier Delattre; Heinrich Kovar; Christoph Bock; Eleni M Tomazou

doi:10.1038/nm.4273

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

Nathan C Sheffield, Gaelle Pierron, Johanna Klughammer, Paul Datlinger, Andreas Schönegger, Michael Schuster, Johanna Hadler, Didier Surdez, Delphine Guillemot, Eve Lapouble, Paul Freneaux, Jacqueline Champigneulle, Raymonde Bouvier, Diana Walder, Ingeborg M Ambros, Caroline Hutter, Eva Sorz, Ana T Amaral, Enrique de Álava, Katharina Schallmoser (Co-author)Dirk Strunk (Co-author), Beate Rinner, Bernadette Liegl-Atzwanger, Berthold Huppertz, Andreas Leithner, Gonzague de Pinieux, Philippe Terrier, Valérie Laurence, Jean Michon, Ruth Ladenstein, Wolfgang Holter, Reinhard Windhager, Uta Dirksen, Peter F Ambros, Olivier Delattre, Heinrich Kovar, Christoph Bock, Eleni M Tomazou

Research output: Contribution to journal › Original Article › peer-review

171 Citations (Web of Science)

Original language	English
Pages (from-to)	386-395
Journal	NATURE MEDICINE
Volume	23
Issue number	3
DOIs	https://doi.org/10.1038/nm.4273
Publication status	Published - 2017

Keywords

CHRONIC LYMPHOCYTIC-LEUKEMIA
REGULATORY REGIONS
GENOMIC LANDSCAPE
ENHANCERS
EPIGENOME
CANCER
TUMORS
DIFFERENTIATION
BINDING
GENES

Access to Document

10.1038/nm.4273

Cite this

Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M., Hadler, J., Surdez, D., Guillemot, D., Lapouble, E., Freneaux, P., Champigneulle, J., Bouvier, R., Walder, D., Ambros, I. M., Hutter, C., Sorz, E., Amaral, A. T., de Álava, E., ... Tomazou, E. M. (2017). DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. NATURE MEDICINE, 23(3), 386-395. https://doi.org/10.1038/nm.4273

@article{46676c2c3c6e451b870e83e81ba7c63c,

title = "DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.",

keywords = "CHRONIC LYMPHOCYTIC-LEUKEMIA, REGULATORY REGIONS, GENOMIC LANDSCAPE, ENHANCERS, EPIGENOME, CANCER, TUMORS, DIFFERENTIATION, BINDING, GENES",

author = "Sheffield, \{Nathan C\} and Gaelle Pierron and Johanna Klughammer and Paul Datlinger and Andreas Sch{\"o}negger and Michael Schuster and Johanna Hadler and Didier Surdez and Delphine Guillemot and Eve Lapouble and Paul Freneaux and Jacqueline Champigneulle and Raymonde Bouvier and Diana Walder and Ambros, \{Ingeborg M\} and Caroline Hutter and Eva Sorz and Amaral, \{Ana T\} and \{de {\'A}lava\}, Enrique and Katharina Schallmoser and Dirk Strunk and Beate Rinner and Bernadette Liegl-Atzwanger and Berthold Huppertz and Andreas Leithner and \{de Pinieux\}, Gonzague and Philippe Terrier and Val{\'e}rie Laurence and Jean Michon and Ruth Ladenstein and Wolfgang Holter and Reinhard Windhager and Uta Dirksen and Ambros, \{Peter F\} and Olivier Delattre and Heinrich Kovar and Christoph Bock and Tomazou, \{Eleni M\}",

note = "Schallmoser, Strunk: Paracelsus Med Univ, Spinal Cord Injury *** Tissue Regenerat Ctr Salzbur, Salzburg, Austria; Schallmoser: Paracelsus Med Univ, Dept Blood Grp Serol *** Transfus Med, Salzburg, Austria; Strunk: Paracelsus Med Univ, Inst Expt *** Clin Cell Therapy, Salzburg, Austria;",

year = "2017",

doi = "10.1038/nm.4273",

language = "English",

volume = "23",

pages = "386--395",

journal = "NATURE MEDICINE",

issn = "1078-8956",

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Sheffield, NC, Pierron, G, Klughammer, J, Datlinger, P, Schönegger, A, Schuster, M, Hadler, J, Surdez, D, Guillemot, D, Lapouble, E, Freneaux, P, Champigneulle, J, Bouvier, R, Walder, D, Ambros, IM, Hutter, C, Sorz, E, Amaral, AT, de Álava, E, Schallmoser, K , Strunk, D, Rinner, B, Liegl-Atzwanger, B, Huppertz, B, Leithner, A, de Pinieux, G, Terrier, P, Laurence, V, Michon, J, Ladenstein, R, Holter, W, Windhager, R, Dirksen, U, Ambros, PF, Delattre, O, Kovar, H, Bock, C & Tomazou, EM 2017, 'DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.', NATURE MEDICINE, vol. 23, no. 3, pp. 386-395. https://doi.org/10.1038/nm.4273

TY - JOUR

T1 - DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

AU - Sheffield, Nathan C

AU - Pierron, Gaelle

AU - Klughammer, Johanna

AU - Datlinger, Paul

AU - Schönegger, Andreas

AU - Schuster, Michael

AU - Hadler, Johanna

AU - Surdez, Didier

AU - Guillemot, Delphine

AU - Lapouble, Eve

AU - Freneaux, Paul

AU - Champigneulle, Jacqueline

AU - Bouvier, Raymonde

AU - Walder, Diana

AU - Ambros, Ingeborg M

AU - Hutter, Caroline

AU - Sorz, Eva

AU - Amaral, Ana T

AU - de Álava, Enrique

AU - Schallmoser, Katharina

AU - Strunk, Dirk

AU - Rinner, Beate

AU - Liegl-Atzwanger, Bernadette

AU - Huppertz, Berthold

AU - Leithner, Andreas

AU - de Pinieux, Gonzague

AU - Terrier, Philippe

AU - Laurence, Valérie

AU - Michon, Jean

AU - Ladenstein, Ruth

AU - Holter, Wolfgang

AU - Windhager, Reinhard

AU - Dirksen, Uta

AU - Ambros, Peter F

AU - Delattre, Olivier

AU - Kovar, Heinrich

AU - Bock, Christoph

AU - Tomazou, Eleni M

N1 - Schallmoser, Strunk: Paracelsus Med Univ, Spinal Cord Injury *** Tissue Regenerat Ctr Salzbur, Salzburg, Austria; Schallmoser: Paracelsus Med Univ, Dept Blood Grp Serol *** Transfus Med, Salzburg, Austria; Strunk: Paracelsus Med Univ, Inst Expt *** Clin Cell Therapy, Salzburg, Austria;

PY - 2017

Y1 - 2017

KW - CHRONIC LYMPHOCYTIC-LEUKEMIA

KW - REGULATORY REGIONS

KW - GENOMIC LANDSCAPE

KW - ENHANCERS

KW - EPIGENOME

KW - CANCER

KW - TUMORS

KW - DIFFERENTIATION

KW - BINDING

KW - GENES

U2 - 10.1038/nm.4273

DO - 10.1038/nm.4273

M3 - Original Article

C2 - 28134926

SN - 1078-8956

VL - 23

SP - 386

EP - 395

JO - NATURE MEDICINE

JF - NATURE MEDICINE

IS - 3

ER -