TY - JOUR
T1 - Diverticulosis and cardiometabolic risk factors
T2 - a systematic literature review
AU - Voelkerer, A
AU - Wernly, S
AU - Semmler, G
AU - Flamm, M
AU - Aigner, E
AU - Datz, C
AU - Wernly, B
N1 - Lehr-KH Oberndorf;
Flamm, B Wernly: Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria; Aigner: Clinic I for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
PY - 2023/9/19
Y1 - 2023/9/19
N2 - BACKGROUND: There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic review has not been performed. We conducted a systematic review to investigate the possible association between cardiometabolic risk factors and diverticulosis.METHODS: A systematic literature search was conducted via PubMed, Cochrane Library, and Web of Science in December 2022 to collect the necessary data. Studies that examined the association between MS or individual metabolic factors and asymptomatic diverticulosis were included in the review.RESULTS: Of the potentially relevant articles identified via PubMed (477), Cochrane Library (224), and Web of Science (296), 29 articles met the inclusion criteria and were used for this work. These studies were assessed for study quality using GRADE. Overall, 6 studies were rated as "very low," 19 studies as "low," and 4 studies as "moderate." The data suggest an association between arterial hypertension, obesity, and fatty liver disease in younger patients and diverticulosis. Patient age appears to play an important role in diverticular formation. Data on diabetes mellitus is inconclusive and may require further investigation depending on the location of the diverticula.CONCLUSION: Based on the synthesized data, there is an association between arterial hypertension, obesity, and fatty liver disease in younger patients. The formation of diverticula seems to be influenced by age and genetic factors. The study suggests a connection with cardiometabolic risk factors. To gain a better understanding of the role of metabolic risk factors in asymptomatic diverticulosis, targeted studies are necessary based on these findings.
AB - BACKGROUND: There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic review has not been performed. We conducted a systematic review to investigate the possible association between cardiometabolic risk factors and diverticulosis.METHODS: A systematic literature search was conducted via PubMed, Cochrane Library, and Web of Science in December 2022 to collect the necessary data. Studies that examined the association between MS or individual metabolic factors and asymptomatic diverticulosis were included in the review.RESULTS: Of the potentially relevant articles identified via PubMed (477), Cochrane Library (224), and Web of Science (296), 29 articles met the inclusion criteria and were used for this work. These studies were assessed for study quality using GRADE. Overall, 6 studies were rated as "very low," 19 studies as "low," and 4 studies as "moderate." The data suggest an association between arterial hypertension, obesity, and fatty liver disease in younger patients and diverticulosis. Patient age appears to play an important role in diverticular formation. Data on diabetes mellitus is inconclusive and may require further investigation depending on the location of the diverticula.CONCLUSION: Based on the synthesized data, there is an association between arterial hypertension, obesity, and fatty liver disease in younger patients. The formation of diverticula seems to be influenced by age and genetic factors. The study suggests a connection with cardiometabolic risk factors. To gain a better understanding of the role of metabolic risk factors in asymptomatic diverticulosis, targeted studies are necessary based on these findings.
KW - Diverticulosis
KW - Metabolic syndrome
KW - Obesity
KW - Arterial hypertension
KW - Diabetes
KW - FATTY LIVER-DISEASE
KW - COLONIC DIVERTICULOSIS
KW - OBESITY
KW - CONSTIPATION
KW - DIET
KW - AGE
U2 - 10.1007/s00384-023-04532-4
DO - 10.1007/s00384-023-04532-4
M3 - Review article
C2 - 37725283
SN - 0179-1958
VL - 38
SP - 236
JO - INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
JF - INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
IS - 1
M1 - 236
ER -