Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.

Veronika Temml; Ulrike Garscha; Erik Romp; Gregor Schubert; Jana Gerstmeier; Zsofia Kutil; Barbara Matuszczak; Birgit Waltenberger; Hermann Stuppner; Oliver Werz; Daniela Brigitte Schuster

doi:10.1038/srep42751

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.

Veronika Temml, Ulrike Garscha, Erik Romp, Gregor Schubert, Jana Gerstmeier, Zsofia Kutil, Barbara Matuszczak, Birgit Waltenberger, Hermann Stuppner, Oliver Werz, Daniela Brigitte Schuster^* (Last author)

^*Corresponding author for this work

Insitute of Pharmacy

Research output: Contribution to journal › Original Article › peer-review

36 Citations (Web of Science)

Original language	English
Pages (from-to)	42751
Journal	Scientific reports
Volume	7
DOIs	https://doi.org/10.1038/srep42751
Publication status	Published - 2017

Keywords

ACTIVATING PROTEIN
DRUG DISCOVERY
LEUKOTRIENE BIOSYNTHESIS
INFLAMMATORY DISEASES
CONFORMER GENERATION
ARACHIDONIC-ACID
FLAP
CHALLENGES
ASTHMA
RISK

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10.1038/srep42751

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Temml, V., Garscha, U., Romp, E., Schubert, G., Gerstmeier, J., Kutil, Z., Matuszczak, B., Waltenberger, B., Stuppner, H., Werz, O., & Schuster, D. B. (2017). Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Scientific reports, 7, 42751. https://doi.org/10.1038/srep42751

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author = "Veronika Temml and Ulrike Garscha and Erik Romp and Gregor Schubert and Jana Gerstmeier and Zsofia Kutil and Barbara Matuszczak and Birgit Waltenberger and Hermann Stuppner and Oliver Werz and Schuster, {Daniela Brigitte}",

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doi = "10.1038/srep42751",

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pages = "42751",

journal = "Scientific reports",

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Temml, V, Garscha, U, Romp, E, Schubert, G, Gerstmeier, J, Kutil, Z, Matuszczak, B, Waltenberger, B, Stuppner, H, Werz, O & Schuster, DB 2017, 'Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.', Scientific reports, vol. 7, pp. 42751. https://doi.org/10.1038/srep42751

TY - JOUR

T1 - Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.

AU - Temml, Veronika

AU - Garscha, Ulrike

AU - Romp, Erik

AU - Schubert, Gregor

AU - Gerstmeier, Jana

AU - Kutil, Zsofia

AU - Matuszczak, Barbara

AU - Waltenberger, Birgit

AU - Stuppner, Hermann

AU - Werz, Oliver

AU - Schuster, Daniela Brigitte

PY - 2017

Y1 - 2017

KW - ACTIVATING PROTEIN

KW - DRUG DISCOVERY

KW - LEUKOTRIENE BIOSYNTHESIS

KW - INFLAMMATORY DISEASES

KW - CONFORMER GENERATION

KW - ARACHIDONIC-ACID

KW - FLAP

KW - CHALLENGES

KW - ASTHMA

KW - RISK

U2 - 10.1038/srep42751

DO - 10.1038/srep42751

M3 - Original Article

C2 - 28218273

SN - 2045-2322

VL - 7

SP - 42751

JO - Scientific reports

JF - Scientific reports

ER -