Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

Daniela Brigitte Schuster; Lyubomir G Nashev; Johannes Kirchmair; Christian Laggner; Gerhard Wolber; Thierry Langer; Alex Odermatt

doi:10.1021/jm800054h

Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

Daniela Brigitte Schuster, Lyubomir G Nashev, Johannes Kirchmair, Christian Laggner, Gerhard Wolber, Thierry Langer, Alex Odermatt

Research output: Contribution to journal › Original Article › peer-review

45 Citations (Web of Science)

Original language	English
Pages (from-to)	4188-4199
Journal	JOURNAL OF MEDICINAL CHEMISTRY
Volume	51
Issue number	14
DOIs	https://doi.org/10.1021/jm800054h
Publication status	Published - 2008

Keywords

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
17-BETA-HYDROXY STEROID DEHYDROGENASE
3D QSAR MODEL
BREAST-CANCER
POTENT INHIBITORS
ACTIVE-SITE
PROGNOSTIC-SIGNIFICANCE
ESTRADIOL
PROTEIN
DESIGN

Access to Document

10.1021/jm800054h

Cite this

Schuster, D. B., Nashev, L. G., Kirchmair, J., Laggner, C., Wolber, G., Langer, T., & Odermatt, A. (2008). Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. JOURNAL OF MEDICINAL CHEMISTRY , 51(14), 4188-4199. https://doi.org/10.1021/jm800054h

Schuster, Daniela Brigitte ; Nashev, Lyubomir G ; Kirchmair, Johannes et al. / Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. In: JOURNAL OF MEDICINAL CHEMISTRY 2008 ; Vol. 51, No. 14. pp. 4188-4199.

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title = "Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.",

keywords = "11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1, 17-BETA-HYDROXY STEROID DEHYDROGENASE, 3D QSAR MODEL, BREAST-CANCER, POTENT INHIBITORS, ACTIVE-SITE, PROGNOSTIC-SIGNIFICANCE, ESTRADIOL, PROTEIN, DESIGN",

author = "Schuster, {Daniela Brigitte} and Nashev, {Lyubomir G} and Johannes Kirchmair and Christian Laggner and Gerhard Wolber and Thierry Langer and Alex Odermatt",

year = "2008",

doi = "10.1021/jm800054h",

language = "English",

volume = "51",

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journal = "JOURNAL OF MEDICINAL CHEMISTRY ",

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Schuster, DB, Nashev, LG, Kirchmair, J, Laggner, C, Wolber, G, Langer, T & Odermatt, A 2008, 'Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.', JOURNAL OF MEDICINAL CHEMISTRY , vol. 51, no. 14, pp. 4188-4199. https://doi.org/10.1021/jm800054h

Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. / Schuster, Daniela Brigitte; Nashev, Lyubomir G; Kirchmair, Johannes et al.
In: JOURNAL OF MEDICINAL CHEMISTRY , Vol. 51, No. 14, 2008, p. 4188-4199.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

AU - Schuster, Daniela Brigitte

AU - Nashev, Lyubomir G

AU - Kirchmair, Johannes

AU - Laggner, Christian

AU - Wolber, Gerhard

AU - Langer, Thierry

AU - Odermatt, Alex

PY - 2008

Y1 - 2008

KW - 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1

KW - 17-BETA-HYDROXY STEROID DEHYDROGENASE

KW - 3D QSAR MODEL

KW - BREAST-CANCER

KW - POTENT INHIBITORS

KW - ACTIVE-SITE

KW - PROGNOSTIC-SIGNIFICANCE

KW - ESTRADIOL

KW - PROTEIN

KW - DESIGN

U2 - 10.1021/jm800054h

DO - 10.1021/jm800054h

M3 - Original Article

C2 - 18533708

SN - 0022-2623

VL - 51

SP - 4188

EP - 4199

JO - JOURNAL OF MEDICINAL CHEMISTRY

JF - JOURNAL OF MEDICINAL CHEMISTRY

IS - 14

ER -

Schuster DB, Nashev LG, Kirchmair J, Laggner C, Wolber G, Langer T et al. Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. JOURNAL OF MEDICINAL CHEMISTRY . 2008;51(14):4188-4199. doi: 10.1021/jm800054h