Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

Gizem Inak; Agnieszka Rybak-Wolf; Pawel Lisowski; Tancredi M Pentimalli; René Jüttner; Petar Glažar; Karan Uppal; Emanuela Bottani; Dario Brunetti; Christopher Secker; Annika Zink; David Meierhofer; Marie-Thérèse Henke; Monishita Dey; Ummi Ciptasari; Barbara Mlody; Tobias Hahn; Maria Berruezo-Llacuna; Nikos Karaiskos; Michela Di Virgilio; Johannes A. Mayr; Saskia Wortmann; Josef Priller; Michael Gotthardt; Dean P Jones; Ertan Mayatepek; Werner Stenzel; Sebastian Diecke; Ralf Kühn; Erich E Wanker; Nikolaus Rajewsky; Markus Schuelke; Alessandro Prigione

doi:10.1038/s41467-021-22117-z

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M Pentimalli, René Jüttner, Petar Glažar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Thérèse Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di VirgilioJohannes A. Mayr (Co-author), Saskia Wortmann (Co-author), Josef Priller, Michael Gotthardt, Dean P Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kühn, Erich E Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione

Department of Pediatrics

Research output: Contribution to journal › Original Article › peer-review

73 Citations (Web of Science)

Original language	English
Pages (from-to)	1929
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-22117-z
Publication status	Published - 2021

Keywords

CYTOCHROME-C-OXIDASE
SURF1

Access to Document

10.1038/s41467-021-22117-z

Cite this

Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T. M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.-T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., ... Prigione, A. (2021). Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome. Nature Communications, 12(1), 1929. https://doi.org/10.1038/s41467-021-22117-z

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title = "Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.",

keywords = "CYTOCHROME-C-OXIDASE, SURF1",

author = "Gizem Inak and Agnieszka Rybak-Wolf and Pawel Lisowski and Pentimalli, {Tancredi M} and Ren{\'e} J{\"u}ttner and Petar Gla{\v z}ar and Karan Uppal and Emanuela Bottani and Dario Brunetti and Christopher Secker and Annika Zink and David Meierhofer and Marie-Th{\'e}r{\`e}se Henke and Monishita Dey and Ummi Ciptasari and Barbara Mlody and Tobias Hahn and Maria Berruezo-Llacuna and Nikos Karaiskos and {Di Virgilio}, Michela and Mayr, {Johannes A.} and Saskia Wortmann and Josef Priller and Michael Gotthardt and Jones, {Dean P} and Ertan Mayatepek and Werner Stenzel and Sebastian Diecke and Ralf K{\"u}hn and Wanker, {Erich E} and Nikolaus Rajewsky and Markus Schuelke and Alessandro Prigione",

note = "Wortmann; Mayr: University Children{\textquoteright}s Hospital, Paracelsus Medical University (PMU), Salzburg, Austria ",

year = "2021",

doi = "10.1038/s41467-021-22117-z",

language = "English",

volume = "12",

pages = "1929",

journal = "Nature Communications",

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Inak, G, Rybak-Wolf, A, Lisowski, P, Pentimalli, TM, Jüttner, R, Glažar, P, Uppal, K, Bottani, E, Brunetti, D, Secker, C, Zink, A, Meierhofer, D, Henke, M-T, Dey, M, Ciptasari, U, Mlody, B, Hahn, T, Berruezo-Llacuna, M, Karaiskos, N, Di Virgilio, M, Mayr, JA , Wortmann, S, Priller, J, Gotthardt, M, Jones, DP, Mayatepek, E, Stenzel, W, Diecke, S, Kühn, R, Wanker, EE, Rajewsky, N, Schuelke, M & Prigione, A 2021, 'Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.', Nature Communications, vol. 12, no. 1, pp. 1929. https://doi.org/10.1038/s41467-021-22117-z

TY - JOUR

T1 - Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

AU - Inak, Gizem

AU - Rybak-Wolf, Agnieszka

AU - Lisowski, Pawel

AU - Pentimalli, Tancredi M

AU - Jüttner, René

AU - Glažar, Petar

AU - Uppal, Karan

AU - Bottani, Emanuela

AU - Brunetti, Dario

AU - Secker, Christopher

AU - Zink, Annika

AU - Meierhofer, David

AU - Henke, Marie-Thérèse

AU - Dey, Monishita

AU - Ciptasari, Ummi

AU - Mlody, Barbara

AU - Hahn, Tobias

AU - Berruezo-Llacuna, Maria

AU - Karaiskos, Nikos

AU - Di Virgilio, Michela

AU - Mayr, Johannes A.

AU - Wortmann, Saskia

AU - Priller, Josef

AU - Gotthardt, Michael

AU - Jones, Dean P

AU - Mayatepek, Ertan

AU - Stenzel, Werner

AU - Diecke, Sebastian

AU - Kühn, Ralf

AU - Wanker, Erich E

AU - Rajewsky, Nikolaus

AU - Schuelke, Markus

AU - Prigione, Alessandro

N1 - Wortmann; Mayr: University Children’s Hospital, Paracelsus Medical University (PMU), Salzburg, Austria

PY - 2021

Y1 - 2021

KW - CYTOCHROME-C-OXIDASE

KW - SURF1

U2 - 10.1038/s41467-021-22117-z

DO - 10.1038/s41467-021-22117-z

M3 - Original Article

C2 - 33771987

SN - 2041-1723

VL - 12

SP - 1929

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -