CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.

M A Province; M P Goetz; H Brauch; D A Flockhart; J M Hebert; R Whaley; V J Suman; W Schroth; S Winter; H Zembutsu; T Mushiroda; W G Newman; M-T M Lee; C B Ambrosone; M W Beckmann; J-Y Choi; A-S Dieudonné; P A Fasching; R Ferraldeschi; L Gong; Elisabeth Haschke-Becher; A Howell; L B Jordan; U Hamann; K Kiyotani; P Krippl; D Lambrechts; A Latif; U Langsenlehner; W Lorizio; P Neven; A T Nguyen; B-W Park; C A Purdie; P Quinlan; W Renner; M Schmidt; M Schwab; J-G Shin; J C Stingl; P Wegman; S Wingren; A H B Wu; E Ziv; G Zirpoli; A M Thompson; V C Jordan; Y Nakamura; R B Altman; M M Ames; R M Weinshilboum; M Eichelbaum; J N Ingle; T E Klein

doi:10.1038/clpt.2013.186

CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.

M A Province, M P Goetz, H Brauch, D A Flockhart, J M Hebert, R Whaley, V J Suman, W Schroth, S Winter, H Zembutsu, T Mushiroda, W G Newman, M-T M Lee, C B Ambrosone, M W Beckmann, J-Y Choi, A-S Dieudonné, P A Fasching, R Ferraldeschi, L GongElisabeth Haschke-Becher (Co-author), A Howell, L B Jordan, U Hamann, K Kiyotani, P Krippl, D Lambrechts, A Latif, U Langsenlehner, W Lorizio, P Neven, A T Nguyen, B-W Park, C A Purdie, P Quinlan, W Renner, M Schmidt, M Schwab, J-G Shin, J C Stingl, P Wegman, S Wingren, A H B Wu, E Ziv, G Zirpoli, A M Thompson, V C Jordan, Y Nakamura, R B Altman, M M Ames, R M Weinshilboum, M Eichelbaum, J N Ingle, T E Klein

Department of Labratory Medicine

Research output: Contribution to journal › Original Article › peer-review

126 Citations (Web of Science)

Original language	English
Pages (from-to)	216-227
Journal	CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume	95
Issue number	2
DOIs	https://doi.org/10.1038/clpt.2013.186
Publication status	Published - 2014

Keywords

BREAST-CANCER PATIENTS
GROUP 1-98 TRIAL
POSTMENOPAUSAL WOMEN
ESTROGEN-RECEPTOR
ACTIVE METABOLITE
POLYMORPHISMS
EFFICACY
BIOTRANSFORMATION
RECURRENCE
MEDICINE

Access to Document

10.1038/clpt.2013.186

Cite this

Province, M. A., Goetz, M. P., Brauch, H., Flockhart, D. A., Hebert, J. M., Whaley, R., Suman, V. J., Schroth, W., Winter, S., Zembutsu, H., Mushiroda, T., Newman, W. G., Lee, M.-T. M., Ambrosone, C. B., Beckmann, M. W., Choi, J.-Y., Dieudonné, A.-S., Fasching, P. A., Ferraldeschi, R., ... Klein, T. E. (2014). CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. CLINICAL PHARMACOLOGY & THERAPEUTICS , 95(2), 216-227. https://doi.org/10.1038/clpt.2013.186

Province, M A ; Goetz, M P ; Brauch, H et al. / CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. In: CLINICAL PHARMACOLOGY & THERAPEUTICS 2014 ; Vol. 95, No. 2. pp. 216-227.

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title = "CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.",

keywords = "BREAST-CANCER PATIENTS, GROUP 1-98 TRIAL, POSTMENOPAUSAL WOMEN, ESTROGEN-RECEPTOR, ACTIVE METABOLITE, POLYMORPHISMS, EFFICACY, BIOTRANSFORMATION, RECURRENCE, MEDICINE",

author = "Province, {M A} and Goetz, {M P} and H Brauch and Flockhart, {D A} and Hebert, {J M} and R Whaley and Suman, {V J} and W Schroth and S Winter and H Zembutsu and T Mushiroda and Newman, {W G} and Lee, {M-T M} and Ambrosone, {C B} and Beckmann, {M W} and J-Y Choi and A-S Dieudonn{\'e} and Fasching, {P A} and R Ferraldeschi and L Gong and Elisabeth Haschke-Becher and A Howell and Jordan, {L B} and U Hamann and K Kiyotani and P Krippl and D Lambrechts and A Latif and U Langsenlehner and W Lorizio and P Neven and Nguyen, {A T} and B-W Park and Purdie, {C A} and P Quinlan and W Renner and M Schmidt and M Schwab and J-G Shin and Stingl, {J C} and P Wegman and S Wingren and Wu, {A H B} and E Ziv and G Zirpoli and Thompson, {A M} and Jordan, {V C} and Y Nakamura and Altman, {R B} and Ames, {M M} and Weinshilboum, {R M} and M Eichelbaum and Ingle, {J N} and Klein, {T E}",

note = "University Institute of Medical and Chemical Laboratory Diagnostics, Paracelsus Private Medical University, Salzburg, Austria",

year = "2014",

doi = "10.1038/clpt.2013.186",

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pages = "216--227",

journal = "CLINICAL PHARMACOLOGY & THERAPEUTICS ",

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Province, MA, Goetz, MP, Brauch, H, Flockhart, DA, Hebert, JM, Whaley, R, Suman, VJ, Schroth, W, Winter, S, Zembutsu, H, Mushiroda, T, Newman, WG, Lee, M-TM, Ambrosone, CB, Beckmann, MW, Choi, J-Y, Dieudonné, A-S, Fasching, PA, Ferraldeschi, R, Gong, L, Haschke-Becher, E, Howell, A, Jordan, LB, Hamann, U, Kiyotani, K, Krippl, P, Lambrechts, D, Latif, A, Langsenlehner, U, Lorizio, W, Neven, P, Nguyen, AT, Park, B-W, Purdie, CA, Quinlan, P, Renner, W, Schmidt, M, Schwab, M, Shin, J-G, Stingl, JC, Wegman, P, Wingren, S, Wu, AHB, Ziv, E, Zirpoli, G, Thompson, AM, Jordan, VC, Nakamura, Y, Altman, RB, Ames, MM, Weinshilboum, RM, Eichelbaum, M, Ingle, JN & Klein, TE 2014, 'CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.', CLINICAL PHARMACOLOGY & THERAPEUTICS , vol. 95, no. 2, pp. 216-227. https://doi.org/10.1038/clpt.2013.186

CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. / Province, M A; Goetz, M P; Brauch, H et al.
In: CLINICAL PHARMACOLOGY & THERAPEUTICS , Vol. 95, No. 2, 2014, p. 216-227.

Research output: Contribution to journal › Original Article › peer-review

TY - JOUR

T1 - CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.

AU - Province, M A

AU - Goetz, M P

AU - Brauch, H

AU - Flockhart, D A

AU - Hebert, J M

AU - Whaley, R

AU - Suman, V J

AU - Schroth, W

AU - Winter, S

AU - Zembutsu, H

AU - Mushiroda, T

AU - Newman, W G

AU - Lee, M-T M

AU - Ambrosone, C B

AU - Beckmann, M W

AU - Choi, J-Y

AU - Dieudonné, A-S

AU - Fasching, P A

AU - Ferraldeschi, R

AU - Gong, L

AU - Haschke-Becher, Elisabeth

AU - Howell, A

AU - Jordan, L B

AU - Hamann, U

AU - Kiyotani, K

AU - Krippl, P

AU - Lambrechts, D

AU - Latif, A

AU - Langsenlehner, U

AU - Lorizio, W

AU - Neven, P

AU - Nguyen, A T

AU - Park, B-W

AU - Purdie, C A

AU - Quinlan, P

AU - Renner, W

AU - Schmidt, M

AU - Schwab, M

AU - Shin, J-G

AU - Stingl, J C

AU - Wegman, P

AU - Wingren, S

AU - Wu, A H B

AU - Ziv, E

AU - Zirpoli, G

AU - Thompson, A M

AU - Jordan, V C

AU - Nakamura, Y

AU - Altman, R B

AU - Ames, M M

AU - Weinshilboum, R M

AU - Eichelbaum, M

AU - Ingle, J N

AU - Klein, T E

N1 - University Institute of Medical and Chemical Laboratory Diagnostics, Paracelsus Private Medical University, Salzburg, Austria

PY - 2014

Y1 - 2014

KW - BREAST-CANCER PATIENTS

KW - GROUP 1-98 TRIAL

KW - POSTMENOPAUSAL WOMEN

KW - ESTROGEN-RECEPTOR

KW - ACTIVE METABOLITE

KW - POLYMORPHISMS

KW - EFFICACY

KW - BIOTRANSFORMATION

KW - RECURRENCE

KW - MEDICINE

U2 - 10.1038/clpt.2013.186

DO - 10.1038/clpt.2013.186

M3 - Original Article

C2 - 24060820

SN - 0009-9236

VL - 95

SP - 216

EP - 227

JO - CLINICAL PHARMACOLOGY & THERAPEUTICS

JF - CLINICAL PHARMACOLOGY & THERAPEUTICS

IS - 2

ER -

Province MA, Goetz MP, Brauch H, Flockhart DA, Hebert JM, Whaley R et al. CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. CLINICAL PHARMACOLOGY & THERAPEUTICS . 2014;95(2):216-227. doi: 10.1038/clpt.2013.186