Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.

Thomas Kocher; Patricia Peking; Alfred Klausegger; Eva Maria Murauer; Josefina Piñón Hofbauer; Verena Wally; Thomas Lettner; Stefan Hainzl; Michael Ablinger; Johann Bauer; Julia Reichelt; Ulrich Koller

doi:10.1016/j.ymthe.2017.08.015

Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.

Thomas Kocher (First author), Patricia Peking (Co-author), Alfred Klausegger (Co-author), Eva Maria Murauer (Co-author), Josefina Piñón Hofbauer (Co-author), Verena Wally (Co-author), Thomas Lettner (Co-author), Stefan Hainzl (Co-author), Michael Ablinger (Co-author), Johann Bauer (Co-author), Julia Reichelt (Co-author), Ulrich Koller^* (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article (Journal) › peer-review

62 Citations (Web of Science)

Original language	English
Pages (from-to)	2585-2598
Journal	MOLECULAR THERAPY
Volume	25
Issue number	11
DOIs	https://doi.org/10.1016/j.ymthe.2017.08.015
Publication status	Published - 2017

Keywords

EPIDERMOLYSIS-BULLOSA SIMPLEX
EPIDERMAL STEM-CELLS
GENE-THERAPY
KERATINOCYTES
TRANSPLANTATION
ENDONUCLEASE
KERATIN-14
DISORDERS
FAMILY
SAFETY

Access to Document

10.1016/j.ymthe.2017.08.015

Cite this

Kocher, T., Peking, P., Klausegger, A., Murauer, E. M., Hofbauer, J. P., Wally, V., Lettner, T., Hainzl, S., Ablinger, M., Bauer, J., Reichelt, J., & Koller, U. (2017). Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases. MOLECULAR THERAPY , 25(11), 2585-2598. https://doi.org/10.1016/j.ymthe.2017.08.015

Kocher, Thomas ; Peking, Patricia ; Klausegger, Alfred et al. / Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases. In: MOLECULAR THERAPY 2017 ; Vol. 25, No. 11. pp. 2585-2598.

@article{51f91d70fc3746f19456875a388403f5,

title = "Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.",

keywords = "EPIDERMOLYSIS-BULLOSA SIMPLEX, EPIDERMAL STEM-CELLS, GENE-THERAPY, KERATINOCYTES, TRANSPLANTATION, ENDONUCLEASE, KERATIN-14, DISORDERS, FAMILY, SAFETY",

author = "Thomas Kocher and Patricia Peking and Alfred Klausegger and Murauer, {Eva Maria} and Hofbauer, {Josefina Pi{\~n}{\'o}n} and Verena Wally and Thomas Lettner and Stefan Hainzl and Michael Ablinger and Johann Bauer and Julia Reichelt and Ulrich Koller",

note = "all but Bauer: House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria, Bauer: Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria",

year = "2017",

doi = "10.1016/j.ymthe.2017.08.015",

language = "English",

volume = "25",

pages = "2585--2598",

journal = "MOLECULAR THERAPY ",

issn = "1525-0016",

number = "11",

}

Kocher, T , Peking, P , Klausegger, A, Murauer, EM, Hofbauer, JP , Wally, V, Lettner, T, Hainzl, S , Ablinger, M , Bauer, J, Reichelt, J & Koller, U 2017, 'Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.', MOLECULAR THERAPY , vol. 25, no. 11, pp. 2585-2598. https://doi.org/10.1016/j.ymthe.2017.08.015

Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases. / Kocher, Thomas (First author); Peking, Patricia (Co-author); Klausegger, Alfred (Co-author) et al.
In: MOLECULAR THERAPY , Vol. 25, No. 11, 2017, p. 2585-2598.

Research output: Contribution to journal › Original Article (Journal) › peer-review

TY - JOUR

T1 - Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.

AU - Kocher, Thomas

AU - Peking, Patricia

AU - Klausegger, Alfred

AU - Murauer, Eva Maria

AU - Hofbauer, Josefina Piñón

AU - Wally, Verena

AU - Lettner, Thomas

AU - Hainzl, Stefan

AU - Ablinger, Michael

AU - Bauer, Johann

AU - Reichelt, Julia

AU - Koller, Ulrich

N1 - all but Bauer: House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria, Bauer: Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria

PY - 2017

Y1 - 2017

KW - EPIDERMOLYSIS-BULLOSA SIMPLEX

KW - EPIDERMAL STEM-CELLS

KW - GENE-THERAPY

KW - KERATINOCYTES

KW - TRANSPLANTATION

KW - ENDONUCLEASE

KW - KERATIN-14

KW - DISORDERS

KW - FAMILY

KW - SAFETY

U2 - 10.1016/j.ymthe.2017.08.015

DO - 10.1016/j.ymthe.2017.08.015

M3 - Original Article (Journal)

C2 - 28888469

SN - 1525-0016

VL - 25

SP - 2585

EP - 2598

JO - MOLECULAR THERAPY

JF - MOLECULAR THERAPY

IS - 11

ER -

Kocher T , Peking P , Klausegger A, Murauer EM, Hofbauer JP , Wally V et al. Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases. MOLECULAR THERAPY . 2017;25(11):2585-2598. doi: 10.1016/j.ymthe.2017.08.015