Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

Mario Gimona; Maria Felice Brizzi; Andre Boon Hwa Choo; Massimo Dominici; Sean M Davidson; Johannes Grillari; Dirk M Hermann; Andrew F Hill; Dominique de Kleijn; Ruenn Chai Lai; Charles P Lai; Rebecca Lim; Marta Monguió-Tortajada; Maurizio Muraca; Takahiro Ochiya; Luis A Ortiz; Wei Seong Toh; Yong Weon Yi; Kenneth W Witwer; Bernd Giebel; Sai Kiang Lim

doi:10.1016/j.jcyt.2021.01.001

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

Mario Gimona (First author)
, Maria Felice Brizzi
, Andre Boon Hwa Choo
, Massimo Dominici
, Sean M Davidson
, Johannes Grillari
, Dirk M Hermann
, Andrew F Hill
, Dominique de Kleijn
, Ruenn Chai Lai
, Charles P Lai
, Rebecca Lim
, Marta Monguió-Tortajada
, Maurizio Muraca
, Takahiro Ochiya
, Luis A Ortiz
, Wei Seong Toh
, Yong Weon Yi
, Kenneth W Witwer
, Bernd Giebel

Sai Kiang Lim

Research output: Contribution to journal › Original Article › peer-review

181 Citations (Web of Science)

Original language	English
Pages (from-to)	373-380
Journal	CYTOTHERAPY
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.jcyt.2021.01.001
Publication status	Published - 2021

Keywords

STEM-CELLS
MICROVESICLES PROTECT
EXOSOMES
HETEROGENEITY

Access to Document

10.1016/j.jcyt.2021.01.001

Cite this

Gimona, M., Brizzi, M. F., Choo, A. B. H., Dominici, M., Davidson, S. M., Grillari, J., Hermann, D. M., Hill, A. F., de Kleijn, D., Lai, R. C., Lai, C. P., Lim, R., Monguió-Tortajada, M., Muraca, M., Ochiya, T., Ortiz, L. A., Toh, W. S., Yi, Y. W., Witwer, K. W., ... Lim, S. K. (2021). Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. CYTOTHERAPY, 23(5), 373-380. https://doi.org/10.1016/j.jcyt.2021.01.001

@article{4e23e966deac487f98bbc97cbd0d758c,

title = "Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.",

keywords = "STEM-CELLS, MICROVESICLES PROTECT, EXOSOMES, HETEROGENEITY",

author = "Mario Gimona and Brizzi, \{Maria Felice\} and Choo, \{Andre Boon Hwa\} and Massimo Dominici and Davidson, \{Sean M\} and Johannes Grillari and Hermann, \{Dirk M\} and Hill, \{Andrew F\} and \{de Kleijn\}, Dominique and Lai, \{Ruenn Chai\} and Lai, \{Charles P\} and Rebecca Lim and Marta Mongui{\'o}-Tortajada and Maurizio Muraca and Takahiro Ochiya and Ortiz, \{Luis A\} and Toh, \{Wei Seong\} and Yi, \{Yong Weon\} and Witwer, \{Kenneth W\} and Bernd Giebel and Lim, \{Sai Kiang\}",

note = "Gimona: Paracelsus Med Univ, Good Mfg Practice Lab, Spinal Cord Injury *** Tissue Regenerat Ctr Salzbur, Salzburg, Austria; Paracelsus Med Univ, Res Program Nanovesicular Therapies, Salzburg, Austria; ",

year = "2021",

doi = "10.1016/j.jcyt.2021.01.001",

language = "English",

volume = "23",

pages = "373--380",

journal = "CYTOTHERAPY",

issn = "1465-3249",

publisher = "Taylor \& Francis ",

number = "5",

}

Gimona, M, Brizzi, MF, Choo, ABH, Dominici, M, Davidson, SM, Grillari, J, Hermann, DM, Hill, AF, de Kleijn, D, Lai, RC, Lai, CP, Lim, R, Monguió-Tortajada, M, Muraca, M, Ochiya, T, Ortiz, LA, Toh, WS, Yi, YW, Witwer, KW, Giebel, B & Lim, SK 2021, 'Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.', CYTOTHERAPY, vol. 23, no. 5, pp. 373-380. https://doi.org/10.1016/j.jcyt.2021.01.001

TY - JOUR

T1 - Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

AU - Gimona, Mario

AU - Brizzi, Maria Felice

AU - Choo, Andre Boon Hwa

AU - Dominici, Massimo

AU - Davidson, Sean M

AU - Grillari, Johannes

AU - Hermann, Dirk M

AU - Hill, Andrew F

AU - de Kleijn, Dominique

AU - Lai, Ruenn Chai

AU - Lai, Charles P

AU - Lim, Rebecca

AU - Monguió-Tortajada, Marta

AU - Muraca, Maurizio

AU - Ochiya, Takahiro

AU - Ortiz, Luis A

AU - Toh, Wei Seong

AU - Yi, Yong Weon

AU - Witwer, Kenneth W

AU - Giebel, Bernd

AU - Lim, Sai Kiang

N1 - Gimona: Paracelsus Med Univ, Good Mfg Practice Lab, Spinal Cord Injury *** Tissue Regenerat Ctr Salzbur, Salzburg, Austria; Paracelsus Med Univ, Res Program Nanovesicular Therapies, Salzburg, Austria;

PY - 2021

Y1 - 2021

KW - STEM-CELLS

KW - MICROVESICLES PROTECT

KW - EXOSOMES

KW - HETEROGENEITY

U2 - 10.1016/j.jcyt.2021.01.001

DO - 10.1016/j.jcyt.2021.01.001

M3 - Original Article

C2 - 33934807

SN - 1465-3249

VL - 23

SP - 373

EP - 380

JO - CYTOTHERAPY

JF - CYTOTHERAPY

IS - 5

ER -