Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study

Luca Calabrese; Marta Tagliabue; Alberto Grammatica; Rita De Berardinis; Federica Corso; Luca Gazzini; Monir Abousiam; Enrico Fazio; Davide Mattavelli; Walter Fontanella; Lorenzo Giannini; Lorenzo Bresciani; Roberto Bruschini; Sara Gandini; Cesare Piazza; Mohssen Ansarin

doi:10.1002/hed.27517

Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study

Luca Calabrese, Marta Tagliabue, Alberto Grammatica, Rita De Berardinis, Federica Corso, Luca Gazzini, Monir Abousiam, Enrico Fazio, Davide Mattavelli, Walter Fontanella, Lorenzo Giannini, Lorenzo Bresciani, Roberto Bruschini, Sara Gandini, Cesare Piazza, Mohssen Ansarin

Krankenhaus Bozen

Research output: Contribution to journal › Original Article › peer-review

Abstract

BACKGROUND: A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).

METHODS: We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.

RESULTS: In the CTS group, survival and prognosis were significantly associated with positive lymph-nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T-N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause-Specific Survival (CSS) of 3.24 (95% CI: 1.71-6.11; p < 0.001); HR Loco-Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47-4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01-0.77; p = 0.03).

CONCLUSION: Performing the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.

Original language	English
Pages (from-to)	2862-2873
Number of pages	12
Journal	HEAD & NECK
Volume	45
Issue number	11
DOIs	https://doi.org/10.1002/hed.27517
Publication status	Published - Nov 2023

Keywords

Humans
Reproducibility of Results
Neoplasm Staging
Tongue/surgery
Carcinoma, Squamous Cell/pathology
Tongue Neoplasms/pathology
Prognosis
Retrospective Studies
Neoplasm Recurrence, Local/pathology

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10.1002/hed.27517

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Calabrese, L., Tagliabue, M., Grammatica, A., De Berardinis, R., Corso, F., Gazzini, L., Abousiam, M., Fazio, E., Mattavelli, D., Fontanella, W., Giannini, L., Bresciani, L., Bruschini, R., Gandini, S., Piazza, C., & Ansarin, M. (2023). Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study. HEAD & NECK, 45(11), 2862-2873. https://doi.org/10.1002/hed.27517

@article{06dacc6a36ec449b86fc78356e4a470a,

title = "Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study",

abstract = "BACKGROUND: A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).METHODS: We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.RESULTS: In the CTS group, survival and prognosis were significantly associated with positive lymph-nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T-N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause-Specific Survival (CSS) of 3.24 (95\% CI: 1.71-6.11; p < 0.001); HR Loco-Regional Recurrence Free Survival (LRRFS) of 2.54 (95\% CI: 1.47-4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95\% CI: 0.01-0.77; p = 0.03).CONCLUSION: Performing the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.",

keywords = "Humans, Reproducibility of Results, Neoplasm Staging, Tongue/surgery, Carcinoma, Squamous Cell/pathology, Tongue Neoplasms/pathology, Prognosis, Retrospective Studies, Neoplasm Recurrence, Local/pathology",

author = "Luca Calabrese and Marta Tagliabue and Alberto Grammatica and \{De Berardinis\}, Rita and Federica Corso and Luca Gazzini and Monir Abousiam and Enrico Fazio and Davide Mattavelli and Walter Fontanella and Lorenzo Giannini and Lorenzo Bresciani and Roberto Bruschini and Sara Gandini and Cesare Piazza and Mohssen Ansarin",

note = "Lehr-KH Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical PrivateUniversity (PMU), Bolzano, Italy",

year = "2023",

month = nov,

doi = "10.1002/hed.27517",

language = "English",

volume = "45",

pages = "2862--2873",

journal = "HEAD \& NECK",

issn = "1043-3074",

publisher = "John Wiley \& Sons ",

number = "11",

}

Calabrese, L, Tagliabue, M, Grammatica, A, De Berardinis, R, Corso, F, Gazzini, L, Abousiam, M, Fazio, E, Mattavelli, D, Fontanella, W, Giannini, L, Bresciani, L, Bruschini, R, Gandini, S, Piazza, C & Ansarin, M 2023, 'Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study', HEAD & NECK, vol. 45, no. 11, pp. 2862-2873. https://doi.org/10.1002/hed.27517

TY - JOUR

T1 - Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma

T2 - A multicentric study

AU - Calabrese, Luca

AU - Tagliabue, Marta

AU - Grammatica, Alberto

AU - De Berardinis, Rita

AU - Corso, Federica

AU - Gazzini, Luca

AU - Abousiam, Monir

AU - Fazio, Enrico

AU - Mattavelli, Davide

AU - Fontanella, Walter

AU - Giannini, Lorenzo

AU - Bresciani, Lorenzo

AU - Bruschini, Roberto

AU - Gandini, Sara

AU - Piazza, Cesare

AU - Ansarin, Mohssen

N1 - Lehr-KH Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical PrivateUniversity (PMU), Bolzano, Italy

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).METHODS: We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.RESULTS: In the CTS group, survival and prognosis were significantly associated with positive lymph-nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T-N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause-Specific Survival (CSS) of 3.24 (95% CI: 1.71-6.11; p < 0.001); HR Loco-Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47-4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01-0.77; p = 0.03).CONCLUSION: Performing the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.

AB - BACKGROUND: A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).METHODS: We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.RESULTS: In the CTS group, survival and prognosis were significantly associated with positive lymph-nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T-N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause-Specific Survival (CSS) of 3.24 (95% CI: 1.71-6.11; p < 0.001); HR Loco-Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47-4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01-0.77; p = 0.03).CONCLUSION: Performing the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.

KW - Humans

KW - Reproducibility of Results

KW - Neoplasm Staging

KW - Tongue/surgery

KW - Carcinoma, Squamous Cell/pathology

KW - Tongue Neoplasms/pathology

KW - Prognosis

KW - Retrospective Studies

KW - Neoplasm Recurrence, Local/pathology

U2 - 10.1002/hed.27517

DO - 10.1002/hed.27517

M3 - Original Article

C2 - 37727894

SN - 1043-3074

VL - 45

SP - 2862

EP - 2873

JO - HEAD & NECK

JF - HEAD & NECK

IS - 11

ER -

Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study

Abstract

Keywords

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