Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases.

Georg Pilz; Regina Steger; Peter Wipfler; Ferdinand Otto; Shahrzad Afazel; Elisabeth Haschke-Becher; Eugen Trinka; Andrea Harrer

doi:10.1016/j.jneuroim.2019.577087

Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases.

Georg Pilz^* (First author), Regina Steger, Peter Wipfler (Co-author), Ferdinand Otto (Co-author), Shahrzad Afazel, Elisabeth Haschke-Becher (Co-author), Eugen Trinka (Co-author), Andrea Harrer (Last author)

^*Corresponding author for this work

Research output: Contribution to journal › Original Article (Journal) › peer-review

10 Citations (Web of Science)

Abstract

To evaluate occurrence and extent of CSF CXCL13 elevations beyond Lyme neuroborreliosis, we investigated CXCL13 in an unselected patient cohort with neuroinflammatory disease. From March 2016 to March 2017, 180 in-patients with CSF pleocytosis were categorized into following groups: pyogenic CNS infections, aseptic meningoencephalitis, neuroimmunological diseases, and reactive pleocytosis. We provide evidence that CXCL13 elevation occurs at variable extent in the majority of neuroinflammatory diseases. The exact role of CXCL13 in CSF is elusive, but the broad occurrence in neuroinflammation points at CNS immune activation, which is not exclusive for LNB.

Original language	English
Pages (from-to)	577087
Journal	JOURNAL OF NEUROIMMUNOLOGY
Volume	338
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577087
Publication status	Published - 2020

Keywords

CEREBROSPINAL-FLUID CXCL13
PROGNOSTIC MARKER
CHEMOKINE CXCL13
BIOMARKER

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10.1016/j.jneuroim.2019.577087

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Pilz, G., Steger, R., Wipfler, P., Otto, F., Afazel, S., Haschke-Becher, E., Trinka, E., & Harrer, A. (2020). Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases. JOURNAL OF NEUROIMMUNOLOGY , 338, 577087. https://doi.org/10.1016/j.jneuroim.2019.577087

Pilz, Georg ; Steger, Regina ; Wipfler, Peter et al. / Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases. In: JOURNAL OF NEUROIMMUNOLOGY 2020 ; Vol. 338. pp. 577087.

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title = "Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases.",

abstract = "To evaluate occurrence and extent of CSF CXCL13 elevations beyond Lyme neuroborreliosis, we investigated CXCL13 in an unselected patient cohort with neuroinflammatory disease. From March 2016 to March 2017, 180 in-patients with CSF pleocytosis were categorized into following groups: pyogenic CNS infections, aseptic meningoencephalitis, neuroimmunological diseases, and reactive pleocytosis. We provide evidence that CXCL13 elevation occurs at variable extent in the majority of neuroinflammatory diseases. The exact role of CXCL13 in CSF is elusive, but the broad occurrence in neuroinflammation points at CNS immune activation, which is not exclusive for LNB.",

keywords = "CEREBROSPINAL-FLUID CXCL13, PROGNOSTIC MARKER, CHEMOKINE CXCL13, BIOMARKER",

author = "Georg Pilz and Regina Steger and Peter Wipfler and Ferdinand Otto and Shahrzad Afazel and Elisabeth Haschke-Becher and Eugen Trinka and Andrea Harrer",

note = "Pilz; Wipfler; Otto; Trinka; Harrer: Department of Neurology, Paracelsus Medical University, Salzburg, Austria; Steger; Afazel; Haschke-Becher: Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria",

year = "2020",

doi = "10.1016/j.jneuroim.2019.577087",

language = "English",

volume = "338",

pages = "577087",

journal = "JOURNAL OF NEUROIMMUNOLOGY ",

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Pilz, G, Steger, R, Wipfler, P , Otto, F, Afazel, S, Haschke-Becher, E , Trinka, E & Harrer, A 2020, 'Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases.', JOURNAL OF NEUROIMMUNOLOGY , vol. 338, pp. 577087. https://doi.org/10.1016/j.jneuroim.2019.577087

Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases. / Pilz, Georg (First author); Steger, Regina; Wipfler, Peter (Co-author) et al.
In: JOURNAL OF NEUROIMMUNOLOGY , Vol. 338, 2020, p. 577087.

Research output: Contribution to journal › Original Article (Journal) › peer-review

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T1 - Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases.

AU - Pilz, Georg

AU - Steger, Regina

AU - Wipfler, Peter

AU - Otto, Ferdinand

AU - Afazel, Shahrzad

AU - Haschke-Becher, Elisabeth

AU - Trinka, Eugen

AU - Harrer, Andrea

N1 - Pilz; Wipfler; Otto; Trinka; Harrer: Department of Neurology, Paracelsus Medical University, Salzburg, Austria; Steger; Afazel; Haschke-Becher: Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria

PY - 2020

Y1 - 2020

N2 - To evaluate occurrence and extent of CSF CXCL13 elevations beyond Lyme neuroborreliosis, we investigated CXCL13 in an unselected patient cohort with neuroinflammatory disease. From March 2016 to March 2017, 180 in-patients with CSF pleocytosis were categorized into following groups: pyogenic CNS infections, aseptic meningoencephalitis, neuroimmunological diseases, and reactive pleocytosis. We provide evidence that CXCL13 elevation occurs at variable extent in the majority of neuroinflammatory diseases. The exact role of CXCL13 in CSF is elusive, but the broad occurrence in neuroinflammation points at CNS immune activation, which is not exclusive for LNB.

AB - To evaluate occurrence and extent of CSF CXCL13 elevations beyond Lyme neuroborreliosis, we investigated CXCL13 in an unselected patient cohort with neuroinflammatory disease. From March 2016 to March 2017, 180 in-patients with CSF pleocytosis were categorized into following groups: pyogenic CNS infections, aseptic meningoencephalitis, neuroimmunological diseases, and reactive pleocytosis. We provide evidence that CXCL13 elevation occurs at variable extent in the majority of neuroinflammatory diseases. The exact role of CXCL13 in CSF is elusive, but the broad occurrence in neuroinflammation points at CNS immune activation, which is not exclusive for LNB.

KW - CEREBROSPINAL-FLUID CXCL13

KW - PROGNOSTIC MARKER

KW - CHEMOKINE CXCL13

KW - BIOMARKER

UR - https://doi.org/10.1016/j.jneuroim.2019.577087

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DO - 10.1016/j.jneuroim.2019.577087

M3 - Original Article (Journal)

C2 - 31715459

SN - 0165-5728

VL - 338

SP - 577087

JO - JOURNAL OF NEUROIMMUNOLOGY

JF - JOURNAL OF NEUROIMMUNOLOGY

ER -

Pilz G, Steger R, Wipfler P , Otto F, Afazel S, Haschke-Becher E et al. Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases. JOURNAL OF NEUROIMMUNOLOGY . 2020;338:577087. doi: 10.1016/j.jneuroim.2019.577087

Beyond LNB: Real life data on occurrence and extent of CSF CXCL13 in neuroinflammatory diseases.

Abstract

Keywords

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