TY - JOUR
T1 - A sex-specific propensity-adjusted analysis of colonic adenoma detection rates in a screening cohort.
AU - Wernly, Sarah
AU - Wernly, Bernhard
AU - Semmler, Georg
AU - Bachmayer, Sebastian
AU - Niederseer, David
AU - Stickel, Felix
AU - Huber-Schönauer, Ursula
AU - Aigner, Elmar
AU - Datz, Christian
N1 - Aigner: Paracelsus Med Univ Salzburg, Dept Med 1, Salzburg, AustriaWernly: Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg, Austria; Lehr-KH: Paracelsus Med Univ Salzburg, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, Paracelsusstr 37, A-5110 Salzburg, Austria;
PY - 2021/9/7
Y1 - 2021/9/7
N2 - The prevalence of colorectal adenoma and advanced adenoma (AA) differs between sexes. Also, the optimal age for the first screening colonoscopy is under debate. We, therefore, performed a sex-specific and age-adjusted comparison of adenoma, AA and advanced neoplasia (AN) rates in a real-world screening cohort. In total, 2824 asymptomatic participants between 45- and 60-years undergoing screening colonoscopy at a single-centre in Austria were evaluated. 46% were females and mean age was 53 ± 4 years. A propensity score for being female was calculated, and adenoma, AA and AN detection rates evaluated using uni- and multivariable logistic regression. Sensitivity analyses for three age groups (group 1: 45 to 49 years, n = 521, 41% females, mean age 47 ± 1 years; group 2: 50 to 54 years, n = 1164, 47% females, mean age 52 ± 1 years; group 3: 55 to 60 years, n = 1139, 46% females, mean age 57 ± 2 years) were performed. The prevalence of any adenoma was lower in females (17% vs. 30%; OR 0.46, 95% CI 0.38-0.55; p
AB - The prevalence of colorectal adenoma and advanced adenoma (AA) differs between sexes. Also, the optimal age for the first screening colonoscopy is under debate. We, therefore, performed a sex-specific and age-adjusted comparison of adenoma, AA and advanced neoplasia (AN) rates in a real-world screening cohort. In total, 2824 asymptomatic participants between 45- and 60-years undergoing screening colonoscopy at a single-centre in Austria were evaluated. 46% were females and mean age was 53 ± 4 years. A propensity score for being female was calculated, and adenoma, AA and AN detection rates evaluated using uni- and multivariable logistic regression. Sensitivity analyses for three age groups (group 1: 45 to 49 years, n = 521, 41% females, mean age 47 ± 1 years; group 2: 50 to 54 years, n = 1164, 47% females, mean age 52 ± 1 years; group 3: 55 to 60 years, n = 1139, 46% females, mean age 57 ± 2 years) were performed. The prevalence of any adenoma was lower in females (17% vs. 30%; OR 0.46, 95% CI 0.38-0.55; p
KW - SESSILE SERRATED ADENOMAS
KW - SOCIETY-TASK-FORCE
KW - COLORECTAL-CANCER
KW - AMERICAN-COLLEGE
KW - RISK-FACTORS
KW - PREVALENCE
KW - COLONOSCOPY
KW - SURVEILLANCE
KW - PERFORMANCE
KW - GUIDELINES
U2 - 10.1038/s41598-021-97163-0
DO - 10.1038/s41598-021-97163-0
M3 - Original Article
C2 - 34493755
SN - 2045-2322
VL - 11
SP - 17785
JO - Scientific reports
JF - Scientific reports
IS - 1
ER -