A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia.

Farrukh T Awan; Peter Hillmen; Andrzej Hellmann; Tadeusz Robak; Steven G Hughes; Denise Trone; Megan Shannon; Ian W Flinn; John C Byrd

doi:10.1111/bjh.13061

A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia.

Farrukh T Awan, Peter Hillmen, Andrzej Hellmann, Tadeusz Robak, Steven G Hughes, Denise Trone, Megan Shannon, Ian W Flinn, John C Byrd

Department of Internal Medicine III - Division of Hematology, Medical Oncology, Hemostaseology, Rheumatology, Infectiology and Oncologic Center

Research output: Contribution to journal › Original Article › peer-review

27 Citations (Web of Science)

Original language	English
Pages (from-to)	466-477
Journal	BRITISH JOURNAL OF HAEMATOLOGY
Volume	167
Issue number	4
DOIs	https://doi.org/10.1111/bjh.13061
Publication status	Published - 2014

Keywords

INITIAL THERAPY
CD23
LYMPHOMA
CHEMOIMMUNOTHERAPY
EXPRESSION
APOPTOSIS
SURVIVAL
REGIMEN
CELLS
TRIAL

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10.1111/bjh.13061

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Awan, F. T., Hillmen, P., Hellmann, A., Robak, T., Hughes, S. G., Trone, D., Shannon, M., Flinn, I. W., & Byrd, J. C. (2014). A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY , 167(4), 466-477. https://doi.org/10.1111/bjh.13061

Awan, Farrukh T ; Hillmen, Peter ; Hellmann, Andrzej et al. / A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia. In: BRITISH JOURNAL OF HAEMATOLOGY 2014 ; Vol. 167, No. 4. pp. 466-477.

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Awan, FT, Hillmen, P, Hellmann, A, Robak, T, Hughes, SG, Trone, D, Shannon, M, Flinn, IW & Byrd, JC 2014, 'A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia.', BRITISH JOURNAL OF HAEMATOLOGY , vol. 167, no. 4, pp. 466-477. https://doi.org/10.1111/bjh.13061

A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia. / Awan, Farrukh T; Hillmen, Peter; Hellmann, Andrzej et al.
In: BRITISH JOURNAL OF HAEMATOLOGY , Vol. 167, No. 4, 2014, p. 466-477.

Research output: Contribution to journal › Original Article › peer-review

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AU - Hillmen, Peter

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AU - Robak, Tadeusz

AU - Hughes, Steven G

AU - Trone, Denise

AU - Shannon, Megan

AU - Flinn, Ian W

AU - Byrd, John C

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KW - CD23

KW - LYMPHOMA

KW - CHEMOIMMUNOTHERAPY

KW - EXPRESSION

KW - APOPTOSIS

KW - SURVIVAL

KW - REGIMEN

KW - CELLS

KW - TRIAL

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DO - 10.1111/bjh.13061

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Awan FT, Hillmen P, Hellmann A, Robak T, Hughes SG, Trone D et al. A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY . 2014;167(4):466-477. doi: 10.1111/bjh.13061