A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Richard Hill, Ravi Kalathur (Co-author), Sergio Callejas, Laura Colaço, Ricardo Brandão, Beatriz Serelde, Antonio Cebriá, Carmen Blanco-Aparicio, Joaquín Pastor, Matthias Futschik, Ana Dopazo, Wolfgang Link

    Research output: Contribution to journalOriginal Articlepeer-review

    35 Citations (Web of Science)
    Original languageEnglish
    Pages (from-to)482
    JournalBREAST CANCER RESEARCH
    Volume16
    Issue number6
    DOIs
    Publication statusPublished - 2014

    Keywords

    • NF-KAPPA-B
    • DNA-BINDING ACTIVITY
    • TRANSCRIPTION FACTORS
    • BREAST-CANCER
    • PIK3CA GENE
    • PHOSPHOINOSITIDE 3-KINASE
    • DRUG DISCOVERY
    • HIGH-FREQUENCY
    • TARGET GENES
    • PATHWAY

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