Alexander Egle

2023

Rituximab Maintenance after Chemoimmunotherapy Induction in 1st and 2nd Line Improves Progression Free Survival: Long Term Follow up of the International Randomized AGMT-CLL8/a Mabtenance Trial

Egle, A., Obrtlikova, P., Smolej, L., Kozak, T., Bohn, J. P., Andel, J., Thaler, J., Mikuskova, E., Gercheva, L., Noesslinger, T., Ladicka, M., Girschikofsky, M., Hrubisko, M., Jaeger, U., Schmitt, C. A., Pecherstorfer, M., Kralikova, E., Burcoveanu, C., Goranov, S. & Jurkovikova, J. & 10 others, Petzer, A. L., Mihaylov, G. G., Raynov, J., Oexle, H., Zabernigg, A. F., Flochova, E., Palasthy, S., Melchardt, T., Mayer, J. & Greil, R., 3 Oct 2023, In: Oncology Research and Treatment. p. 35-35 1 p.

Research output: Contribution to journal › Abstract (Journal) › peer-review

2022

Randomized Comparison between Krd and Ktd Induction, Followed By K Maintenance or Control in Transplant NonEligible Patients with NDMM: Efficacy and Qol Data (AGMT-MM02 Trial)

Ludwig, H., Melchardt, T., Sormann, S., Zojer, N., Andel, J., Hartmann, B., Tinchon, C., Gunsilius, E., Podar, K., Egle, A., Willenbacher, W., Woll, E., Schreder, M., Ruckser, R., Bozic, B., Krauth, M., Petzer, A., Schmitt, C., Machherndl-Spandl, S. & Agis, H. & 6 others, Fillitz, M., Wang, S., Knop, S., Kainz, S., Paiva, B. & Greil, R., 2022, In: BLOOD . 140, p. 10185-10188

Research output: Contribution to journal › Abstract (Journal) › peer-review

2021

Clinical Presentation of Patients with Adult Late-Onset Telomere Biology Disorders - Results from the Aachen Telomeropathy Registry

Beier, F., Tometten, M., Kirschner, M., Halfmeyer, I., Vieri, M., Kricheldorf, K., Maurer, A., Roeth, A., Platzbecker, U., Radsak, M., Schafhausen, P., Corbacioglu, S., Hoechsmann, B., Wilk, C., Hinze, C., Chromik, J., Egle, A., Heuser, M., Kreuter, M. & Kurth, I. & 5 others, Koschmieder, S., Panse, J., Meyer, R., Isfort, S. & Brummendorf, T., 2021, In: BLOOD . 138

Research output: Contribution to journal › Abstract (Journal) › peer-review

Composition of the Immune Environment at Baseline Correlates with Time to Response and Treatment Outcome in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (MM) Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Observation (AGMT_MM 02 Study)

Manrique, I., Greil, R., Andel, J., Sormann, S., Hartmann, B., Podar, K., Egle, A., Petzer, A., Zojer, N., Gunsilius, E., Ruckser, R., Bozic, B., Schmitt, C., Machherndl-Spandl, S., Agis, H., Schreder, M., Wang, S., Willenbacher, W., Krauth, M. & Tinchon, C. & 5 others, Fillitz, M., Melchardt, T., Knop, S., Paiva, B. & Ludwig, H., 2021, In: BLOOD . 138

Research output: Contribution to journal › Abstract (Journal) › peer-review

Lack of Bmf Facilitates the Selection of Highly Responsive B-Cell Receptor Clones in Chronic Lymphocytic Leukemia

Maeding, N., Asslaber, D., Zaborsky, N., Villunger, A., Greil, R. & Egle, A., 2021, In: BLOOD . 138

Research output: Contribution to journal › Abstract (Journal) › peer-review

Peripheral Blood Complete Remission Provides Added Value to the Classical Definition of Morphologic Complete Remission - a Prospective Cohort Study of 1441 Patients with MDS, CMML and AML Treated within the Austrian Azacitidine Registry

Pleyer, L., Pfeilstocker, M., Stauder, R., Heibl, S., Sill, H., Girschikofsky, M., Stampfl-Mattesberger, M., Tinchon, C., Hartmann, B., Petzer, A., Petricevic, B., Schmitt, C., Vallet, S., Geissler, K., Sperr, W., Leisch, M., Egle, A., Melchardt, T., Piringer, G. & Zebisch, A. & 7 others, Machherndl-Spandl, S., Wolf, D., Keil, F., Angermann, H., Drost, M., Larcher-Senn, J. & Greil, R., 2021, In: BLOOD . 138

Research output: Contribution to journal › Abstract (Journal) › peer-review

3 Citations (Web of Science)

The EQ-5D-5L Predicts Treatment Outcomes and Provides Added Value to the R-IPSS in Patients with MDS, CMML or AML Treated within the Austrian Azacitidine Registry - a Prospective Cohort Study By the AGMT Study Group

Pleyer, L., Heibl, S., Tinchon, C., Vallet, S., Petricevic, B., Leisch, M., Egle, A., Senn, T., Grochtdreis, T., Greil, R. & Stauder, R., 2021, In: BLOOD . 138

Research output: Contribution to journal › Abstract (Journal) › peer-review

2020

COVID-19 treatment by anti-coagulation: anti-thrombotic and anti-inflammatory?

Paar, V., Wernly, B., Zhou, Z., Motloch, L., Hoppe, U., Egle, A. & Lichtenauer, M., 2020, In: WIENER KLINISCHE WOCHENSCHRIFT. 132, p. S217-S217

Research output: Contribution to journal › Abstract (Journal) › peer-review

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia

Hartmann, T., Szenes, E., Polcik, L., Decker, S., Haslauer, T., Pischeli, J., Kissel, S., Hopner, J., Egle, A., Zaborsky, N., Dierks, C., Greil, R., Gattei, V. & Harzschel, A., 2020, In: Oncology Research and Treatment. 43, SUPPL 4, p. 70-70

Research output: Contribution to journal › Abstract (Journal) › peer-review

2019

A 3-gene DNA methylation signature fails to predict response to bevacizumab in metastatic breast cancer patients treated within the TANIA phase III trial

Gampenrieder, S. P., Angela, R., Rinnerthaler, G., Hackl, H., Steiner, M., Pulverer, W., Weinhaeusel, A., Klinglmayr, E., Karl, T., Ilic, S., Hufnagl, C., Hauser-Kronberger, C., Egle, A. & Greil, R., 2019, In: CANCER RESEARCH . 79, 4

Research output: Contribution to journal › Abstract (Journal) › peer-review

B-cell specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhancing tumor immune evasion

Asslaber, D., Qi, Y., Maeding, N., Denk, U., Hopner, J., Hartmann, T., Zaborsky, N., Greil, R. & Egle, A., 2019, In: Oncology Research and Treatment. 42, p. 17-18

Research output: Contribution to journal › Abstract (Journal) › peer-review

Cardiovascular events are declining in men with HIV aged 50 years or older in Austria

Rappold, M., Kitchen, M., Rieger, A., Schmied, B., Ollinger, A., Egle, A., Wallner, E., Kanatschnig, M., Zoufaly, A., Ledergerber, B. & Zangerle, R., 2019, In: HIV MEDICINE. 20, p. 118-119

Research output: Contribution to journal › Abstract (Journal) › peer-review

Similar but different: Using combined phylogenies of Austria and Switzerland reveals differences in transmission patterns of the local HIV-1 epidemics

Kusejko, K., Battegay, M., Bernasconi, E., Boni, J., Calmy, A., Cavassini, M., Egle, A., Grabmeier-Pfistershammer, K., Haas, B., Klimkait, T., Ollinger, A., Perreau, M., Ramette, A., Flury, B., Sarcletti, M., Scherrer, A., Schmid, P., Yerly, S., Zangerle, R. & Gunthard, H. & 1 others, Kouyos, R., 2019, In: HIV MEDICINE. 20, p. 29-29

Research output: Contribution to journal › Abstract (Journal) › peer-review

The hepatitis C continuum of care among HIV-infected individuals in Austria

Rappold, M., Gisinger, M., Chromy, D., Schmied, B., Ollinger, A., Wallner, E., Zoufaly, A., Egle, A., Kanatschnig, M. & Zangerle, R., 2019, In: HIV MEDICINE. 20, p. 193-193

Research output: Contribution to journal › Abstract (Journal) › peer-review

Unmaintained remission after discontinuation of kinase inhibitor treatment in chronic lymphocytic leukemia: an observational cohort

Egle, A., Jager, U., Skrabs, C., Durig, J., Nosslinger, T., Wanner, D., Steurer, M., Ringshausen, I., Melchardt, T., Greil, R. & Ysebaert, L., 2019, In: Oncology Research and Treatment. 42, p. 18-18

Research output: Contribution to journal › Abstract (Journal) › peer-review

2018

Deletion of the p53 Target Gene PUMA Prevents Bone Marrow Failure in a Dyskeratosis Congenita Mouse Model

Erlacher, M., Molnar, C., Weiss, J., Bohler, S., Steinemann, D., Gohring, G., Villunger, A., Labi, V., Niemeyer, C. & Egle, A., 2018, In: BLOOD . 132

Research output: Contribution to journal › Abstract (Journal) › peer-review

Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer

Hufnagl, C., Leisch, M., Weiss, L., Melchardt, T., Moik, M., Geisberger, R., Asslaber, D., Steininger, P., Meissnitzer, T., Neureiter, D., Greil, R. & Egle, A., 2018, In: Oncology Research and Treatment. 41, p. 307-307

Research output: Contribution to journal › Abstract (Journal) › peer-review

Exome sequencing of tumors from the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

Egle, A., Gassner, F. J., Hopner, J., Hebenstreit, D., Stark, R., Asslaber, D., Steiner, M., Geisberger, R., Greil, R. & Zaborsky, N., 2018, In: Oncology Research and Treatment. 41, p. 31-31

Research output: Contribution to journal › Abstract (Journal) › peer-review

Long-Term Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Polycythemia Vera - Final Phase I/II Peginvera Study Results

Gisslinger, H., Buxhofer-Ausch, V., Thaler, J., Forjan, E., Willenbacher, E., Wolf, D., Kralovics, R., Gisslinger, B., Stampfl-Mattersberger, M., Egle, A., Melchardt, T., Burgstaller, S., Schalling, M., Krauth, M., Greil, R., Kadlecova, P., Zoerer, M., Empson, V., Grohmann-Izay, B. & Klade, C., 2018, In: BLOOD . 132

Research output: Contribution to journal › Abstract (Journal) › peer-review

13 Citations (Web of Science)

Spatial heterogeneity in diffuse large B-cell lymphoma

Magnes, T., Melchardt, T., Thorner, A., Neureiter, D., Klieser, E., Greil, R. & Egle, A., 2018, In: Oncology Research and Treatment. 41, p. 243-244

Research output: Contribution to journal › Abstract (Journal) › peer-review

The HIV continuum of care in Austria from 2010 to 2016: data and challenges

Leierer, G., van Sighem, A., Rieger, A., Schmied, B., Sarcletti, M., Ollinger, A., Haas, B., Egle, A., Rappold, M. & Zangerle, R., 2018, In: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

2017

Casein Kinase 1 delta/epsilon inhibition blocks CLL chemotaxis and delays leukemia onset in the E mu-TCL1 mouse model of chronic lymphocytic leukemia

Janovska, P., Verner, J., Kohoutek, J., Bryjoval, L., Dzimkova, M., Skabrahova, H., Radaszkiewicz, T., Nemcova, T., Hoferova, Z., Vasickova, K., Smyckova, L., Gregorova, M., Egle, A., Pavlova, S., Poppova, L., Pospisilova, S. & Bryja, V., 2017, In: LEUKEMIA & LYMPHOMA . 58, p. 210-211

Research output: Contribution to journal › Abstract (Journal) › peer-review

Low expression of miR-20a-5p predicts benefit to bevacizumab in metastatic breast cancer patients treated within the TANIA trial

Gampenrieder, S., Rinnerthaler, G., Hackl, H., Steiner, M., Fuentes, C., Hufnagl, C., Hauser-Kronberger, C., Egle, A. & Greil, R., 2017, In: ANNALS OF ONCOLOGY . 28

Research output: Contribution to journal › Abstract (Journal) › peer-review

1 Citation (Web of Science)

SUCCESSFUL LONG-TERM MAINTENANCE OF PV PATIENTS WITH A MONTHLY SCHEDULE OF ROPEGINTERFERON ALFA-2B-AN UPDATE FROM THE PEGINVERA STUDY

Buxhofer-Ausch, V., Grohmann-Izay, B., Thaler, J., Schloegl, E., Gastl, G., Wolf, D., Kralovics, R., Gisslinger, B., Ban, S., Egle, A., Melchardt, T., Burgstaller, S., Willenbacher, E., Schalling, M., Krauth, M., Greil, R., Zoerer, M., Kadlecova, P., Klade, C. & Gisslinger, H., 2017, In: HAEMATOLOGICA . 102, p. 284-284

Research output: Contribution to journal › Abstract (Journal) › peer-review

2016

An elevated fibrinogen/CRP ratio predicts a remarkable survival advantage in patients with metastatic pancreatic cancer

Winder, T., Posch, F., Asamer, E., Stotz, M., Siebenhuner, A., Schlick, K., Magnes, T., Samaras, P., Szkandera, J., Clavien, P., Neureiter, D., Greil, R., Pestalozzi, B., Stoeger, H., Gerger, A., Egle, A. & Pichler, M., 2016, In: ANNALS OF ONCOLOGY . 27

Research output: Contribution to journal › Abstract (Journal) › peer-review

CXCL12 ANTAGONISM BY THE L-RNA APTAMER OLAPTESED PEGOL IS EFFECTIVE AS A MOBILIZING AND THERAPEUTIC AGENT IN A MURINE CHRONIC LYMPHOCYTIC LEUKEMIA MODEL

Hinterseer, E., Hutterer, E., Krenn, P., Reinthaler, P., Hopner, J. (Co-author), Hopfinger, M., Eulberg, D., Maasch, C., Kruschinski, A., Vater, A., Egle, A., Greil, R. & Hartmann, T., 2016, In: HAEMATOLOGICA . 101, p. 45-46

Research output: Contribution to journal › Abstract (Journal) › peer-review

2015

Combination of age, ABC-type and intratumoral T-regulator cells are a negative prognostic factors for primary extranodal diffuse large B-cell lymphoma

Tränkenschuh, W., Kemmerling, R., Alinger, B., Melchardt, T., Egle, A., Kiesslich, T. & Neureiter, D., 2015, In: PATHOLOGE . 36, p. 110-110

Research output: Contribution to journal › Abstract (Journal) › peer-review

Four Weeks Administration Schedule of Ropeginterferon Alfa-2b (AOP2014/P1101) in Polycythemia Very Patients Allows Maintaining of Efficacy with Favorable Toxicity Profile in the Phase I/II Peginvera Stud

Buxhofer-Ausch, V., Gisslinger, H., Thaler, J., Schlogl, E., Gastl, G., Wolf, D., Kralovics, R., Gisslinger, B., Ban, S., Egle, A., Melchardt, T., Burgstaller, S., Willenbacher, E., Schalling, M., Krauth, M., Them, N., Zorer, M., Ammann-Mwathi, O., Kadlecova, P. & Zagrijtschuk, O. & 2 others, Klade, C. & Greil, R., 2015, In: BLOOD . 126, 23

Research output: Contribution to journal › Abstract (Journal) › peer-review

Long Term Efficacy and Safety Results and Analysis of Dose Correlations from the Phase I/II Peginvera Study of Ropeginterferon Alfa-2b, a Novel IFNa-2b, in Polycythemia Vera Patient

Gisslinger, H., Buxhofer-Ausch, V., Thaler, J., Schlogl, E., Gastl, G., Wolf, D., Schalling, M., Gisslinger, B., Ban, S., Egle, A., Melchardt, T., Burgstaller, S., Willenbacher, E., Krauth, M., Them, N., Kralovics, R., Zorer, M., Ammann-Mwathi, O., Kadlecova, P. & Zagrijtschuk, O. & 2 others, Klade, C. & Greil, R., 2015, In: BLOOD . 126, 23

Research output: Contribution to journal › Abstract (Journal) › peer-review

MRD dynamics after chemoimmunotherapy induction treatment of CLL independently predict outcome: first analysis of a secondary endpoint from the international randomized AGMT-CLL8/a Mabtenance trial

Egle, A., Doubek, M., Stehlikova, O., Pleyer, L., Altenhofer, P., Melchardt, T., Smolej, L., Mihaylov, G., Mikuskova, E., Mayer, J. & Greil, R., 2015, In: LEUKEMIA & LYMPHOMA . 56, p. 123-124

Research output: Contribution to journal › Abstract (Journal) › peer-review

2014

A Complementary Role of High Throughput Sequencing and Multiparameter Cytometry for Minimal Residual Disease (MRD) Detection in Chronic Lymphocytic Leukemia (CLL):an European Research Initiative (ERIC) Study

Rawstron, A., Fazi, C., Villamor, N., Delgado, J., Letestu, R., Cymbalista, F., Palacio, C., Bosch, F., De Tute, R., Liptrot, S., OxxxBrien, D., Spacek, M., Dobber, J., Kater, A., Gambell, P., Westerman, D., Soosapilla, A., Mulligan, S., Lozanski, G. & Lin, K. & 29 others, Pettitt, A., Brachtl, G., Egle, A., Williamson, D., Sanders, C., Robins, H., Boysen, J., Shanafelt, T., Hanson, C., Jorgensen, J., Wierda, W., Yuan, C., Stetler-Stevenson, M., Rassenti, L., Broome, H., Kipps, T., Hauwel, M., Marinov, I., Craig, F., Josep, N., Moreno, C., Stehlikova, O., Doubek, M., Pospisilova, S., Kreuzer, K., Hallek, M., Hillmen, P., Montserrat, E. & Ghia, P., 2014, In: BLOOD . 124, 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

Chronic Lymphocytic Leukaemia Cells with Trisomy 12 Home to the Bone Marrow in a CXCR4-Independent Manner

Hutterer, E., Ganghammer, S., Hinterseer, E., Brachtl, G., Asslaber, D., Krenn, P., Girbl, T., Berghammer, P., Geisberger, R., Egle, A., Zucchetto, A., Gattei, V., Chigaev, A., Greil, R. & Hartmann, T., 2014, In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY . 79, 6, p. 468-468

Research output: Contribution to journal › Abstract (Journal) › peer-review

CLL INDUCES SEVERE SKEWING IN THE MYELOID COMPARTMENT IN PATIENTS AND IN THE TCL1 MOUSE MODEL

Hanna, B., McClanahan, F., Zaborsky, N., Durr, C., Gschwend, V., Stilgenbauer, S., Egle, A., Gribben, J., Lichter, P. & Seiffert, M., 2014, In: HAEMATOLOGICA . 99, p. 228-229

Research output: Contribution to journal › Abstract (Journal) › peer-review

Targeting Dysfunctional Myeloid Cells Delays Disease Development and Improves Immune Function in a CLL Mouse Model

Hanna, B., McClanahan, F., Zaborsky, N., Durr, C., Kalter, V., Egle, A., Gribben, J., Lichter, P. & Seiffert, M., 2014, In: BLOOD . 124, 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

The integrin VLA-4 shows impaired CXCL12-induced inside-out activation in trisomy12 harboring chronic lymphocytic leukemia (CLL) cells

Ganghammer, S., Hutterer, E., Hinterseer, E., Brachtl, G., Asslaber, D., Krenn, P., Girbl, T., Berghammer, P., Geisberger, R., Egle, A., Zucchetto, A., Gattei, V., Chigaev, A., Greil, R. & Hartmann, T., 2014, In: Oncology Research and Treatment. 37, p. 222-222

Research output: Contribution to journal › Abstract (Journal) › peer-review

The Spiegelmer (R) NOX-A12 Mobilizes CLL Cells from Lymphoid Organs and Prevents Their Recirculation

Hinterseer, E., Girbl, T., Hutterer, E., Berghammer, P., Ganghammer, S., Sifft, E., Pinon-Hofbauer, J., Egle, A., Kruschinski, A., Greil, R. & Hartmann, T., 2014, In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY . 79, 6, p. 468-469

Research output: Contribution to journal › Abstract (Journal) › peer-review

2012

AOP2014, a Novel Peg-Proline-Interferon Alpha-2b with Improved Pharmacokinetic Properties, Is Safe and Well Tolerated and Shows Promising Efficacy in Patients with Polycythemia Vera (PV)

Gisslinger, H., Kralovics, R., Gisslinger, B., Lechner, D., Buxhofer-Ausch, V., Strecker, K., Gastl, G., Willenbacher, E., Greil, R., Egle, A., Melchardt, T., Burgstaller, S., Schloegl, E., Tarmann, F., Zoerer, M., Klade, C., Zahriychuk, O. & Thaler, J., 2012, In: BLOOD . 120, 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

2 Citations (Web of Science)

Complications of 5-azacytidine: Three cases of severe colitis in a single center cohort

Melchardt, T., Weiss, L., Pleyer, L., Steinkirchner, S., Greil, R. & Egle, A., 2012, In: ONKOLOGIE . 35, p. 149-149

Research output: Contribution to journal › Abstract (Journal) › peer-review

Feasibility of anthracycline based treatment in unselected elderly DLBCL patients

Melchardt, T., Weiss, L., Hufnagl, C., Neureiter, D., Kemmerling, R., Hopfinger, G., Greil, R. & Egle, A., 2012, In: ONKOLOGIE . 35, p. 86-87

Research output: Contribution to journal › Abstract (Journal) › peer-review

Protein Kinase C-beta Dependent Activation of NF-kappa B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B-Cells in Vivo

Lutzny, G., Kocher, T., Rudelius, M., Schmidt-Supprian, M., Klein-Hitpass, L., Durig, J., Oostendorp, R., Peschel, C., Egle, A. & Ringshausen, I., 2012, In: BLOOD . 120, 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

T Cell Exhaustion Contributes to Immune Evasion in Chronic Lymphocytic Leukaemia

Gassner, F. J., Zaborsky, N., Neureiter, D., Huemer, M., Egle, A., Hartmann, T., Greil, R. & Geisberger, R., 2012, In: BLOOD . 120, 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

Treatment of Aggressive B-Cell Lymphoma in the Elderly: The Influence of SNPs Affecting Pharmacodynamics Is Different Compared to Younger Patient

Melchardt, T., Weiss, L., Hufnagl, C., Neureiter, D., Kemmerling, R., Morre, P., Boekstegers, A., Hopfinger, G., Greil, R. & Egle, A., 2012, In: BLOOD . 120, 21

Research output: Contribution to journal › Abstract (Journal) › peer-review

Upgraded Cobas TaqMan version 2: hidden consequences at cohort level

Taylor, N., Grabmeier-Pfistershammer, K., Oberkofler, H., Egle, A., Rieger, A. & Ledergerber, B., 2012, In: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 15, 6, p. 109-109

Research output: Contribution to journal › Abstract (Journal) › peer-review

2011