Targeting TGF-ss in the Central Nervous System: Assessment of Cynomolgus Monkey-Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide

S Peters; E Wirkert; S Kuespert; R Heydn; S Korte; L Mecklenburg; Ludwig Aigner; S Johannesen; TH Bruun; U Bogdahn

doi:10.3390/app12030973

Targeting TGF-ss in the Central Nervous System: Assessment of Cynomolgus Monkey-Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide

S Peters, E Wirkert, S Kuespert, R Heydn, S Korte, L Mecklenburg, Ludwig Aigner (Co-Autor/-in), S Johannesen, TH Bruun, U Bogdahn

Universitätsinstitut für Molekulare Regenerative Medizin

Publikation: Beitrag in Fachzeitschrift › Originalarbeit › Begutachtung

Originalsprache	Englisch
Seiten (von - bis)	973
Fachzeitschrift	Applied Sciences - Basel
Jahrgang	12
Ausgabenummer	3
DOIs	https://doi.org/10.3390/app12030973
Publikationsstatus	Veröffentlicht - 2022

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10.3390/app12030973

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title = "Targeting TGF-ss in the Central Nervous System: Assessment of Cynomolgus Monkey-Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide",

keywords = "BETA, NEURODEGENERATION, INHIBITION, THERAPIES",

author = "S Peters and E Wirkert and S Kuespert and R Heydn and S Korte and L Mecklenburg and Ludwig Aigner and S Johannesen and TH Bruun and U Bogdahn",

note = "Aigner, Ludwig: Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria",

year = "2022",

doi = "10.3390/app12030973",

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T1 - Targeting TGF-ss in the Central Nervous System: Assessment of Cynomolgus Monkey-Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide

AU - Peters, S

AU - Wirkert, E

AU - Kuespert, S

AU - Heydn, R

AU - Korte, S

AU - Mecklenburg, L

AU - Aigner, Ludwig

AU - Johannesen, S

AU - Bruun, TH

AU - Bogdahn, U

N1 - Aigner, Ludwig: Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria

PY - 2022

Y1 - 2022

KW - BETA

KW - NEURODEGENERATION

KW - INHIBITION

KW - THERAPIES

U2 - 10.3390/app12030973

DO - 10.3390/app12030973

M3 - Original Article

SN - 2076-3417

VL - 12

SP - 973

JO - Applied Sciences - Basel

JF - Applied Sciences - Basel

IS - 3

ER -